本文關(guān)鍵詞： miRNA 子宮內(nèi)膜癌 發(fā)生發(fā)展 轉(zhuǎn)移 耐藥　出處：《中國(guó)婦產(chǎn)科臨床雜志》2015年01期 　論文類型：期刊論文

【摘要】：miRNA(microRNA)是一類內(nèi)源性的非編碼單鏈小分子RNA,隨著近年來對(duì)其研究的不斷深入,發(fā)現(xiàn)miRNA與特定基因的沉默或/和保護(hù)某些基因組免受外源性干擾等密切相關(guān)。miRNA通過與靶mRNA特異性結(jié)合使其降解、干擾翻譯,參與生物體的增殖、分化和凋亡等生命活動(dòng)。miRNA在多種腫瘤中都存在表達(dá)異常,提示其在腫瘤的發(fā)生發(fā)展中扮演著重要的角色。子宮內(nèi)膜癌(endometrial cancer,EC)是婦科三大惡性腫瘤之一,發(fā)病機(jī)制尚未明確,越來越多的學(xué)者們開始關(guān)注miRNA表達(dá)譜的異常與子宮內(nèi)膜癌的發(fā)生、發(fā)展、臨床治療等的相關(guān)性,本文就miRNA在子宮內(nèi)膜癌中的研究進(jìn)展做一綜述。
[Abstract]:MiRNAs microRNAs (miRNAs) are a class of endogenous non-coding single-stranded small RNAs, which have been studied in recent years. It is found that miRNA is closely related to the silencing of specific genes and / or the protection of certain genomes from exogenous interference. MiRNAs are specifically combined with target mRNA to degrade them and interfere with translation. The expression of miRNA is abnormal in many kinds of tumors, such as proliferation, differentiation and apoptosis. It is suggested that endometrial carcinoma is one of the three major gynecological malignancies, and its pathogenesis is not clear. More and more scholars begin to pay attention to the correlation between abnormal miRNA expression profile and the occurrence, development, clinical treatment of endometrial carcinoma. This article reviews the research progress of miRNA in endometrial carcinoma.
【作者單位】： 福建醫(yī)科大學(xué)附屬協(xié)和臨床醫(yī)學(xué)院;福建省婦幼保健院;福建醫(yī)科大學(xué)附屬協(xié)和醫(yī)院婦產(chǎn)科;
【分類號(hào)】：R737.33
【正文快照】： 子宮內(nèi)膜癌是女性生殖道三大惡性腫瘤之一,近年來發(fā)病率有上升的趨勢(shì),居女性患癌排名的第4位,僅次于乳腺癌、肺癌和大腸癌[1],盡快明確其發(fā)病機(jī)制是達(dá)到治療目的的根本途徑。目前認(rèn)為多數(shù)的EC與長(zhǎng)期暴露于無抵抗的雌激素相關(guān),但并非所有類型子宮內(nèi)膜癌都是激素依賴性,近年來研，

本文編號(hào)：1442793