本文關(guān)鍵詞：北京地區(qū)孕早期婦女紅細(xì)胞葉酸水平及適宜葉酸補(bǔ)充時(shí)間劑量　出處：《衛(wèi)生研究》2017年04期 　論文類(lèi)型：期刊論文

  更多相關(guān)文章： 孕早期婦女 紅細(xì)胞葉酸 橫斷面調(diào)查 營(yíng)養(yǎng)素補(bǔ)充

【摘要】：目的了解北京地區(qū)孕早期婦女紅細(xì)胞葉酸水平,探討葉酸制劑適宜補(bǔ)充時(shí)間及劑量。方法以孕早期在北京市海淀區(qū)婦幼保健院營(yíng)養(yǎng)門(mén)診就診孕婦作為調(diào)查對(duì)象,共3458人,末次月經(jīng)2014年2月1日至2016年1月31日采用橫斷面調(diào)查方法,收集孕婦人口學(xué)特征數(shù)據(jù)、葉酸補(bǔ)充相關(guān)信息及相關(guān)臨床數(shù)據(jù)。采用競(jìng)爭(zhēng)結(jié)合受體測(cè)定方法測(cè)定紅細(xì)胞葉酸水平。結(jié)果孕婦紅細(xì)胞葉酸水平為(806.5±273.7)ng/mL,不同年齡組間紅細(xì)胞葉酸水平差異有統(tǒng)計(jì)學(xué)意義(P0.001);大學(xué)及以上文化程度組孕婦葉酸水平更高(P=0.030);家庭月收入10 000元組孕婦顯著高于其他各組(P0.001);夏秋季較冬春季紅細(xì)胞葉酸水平高(P0.001);孕婦紅細(xì)胞葉酸水平隨著葉酸補(bǔ)充劑量、時(shí)間逐漸升高(P均0.001)。以參考值1180nmol/L(521 ng/mL)評(píng)價(jià),孕早期葉酸水平達(dá)標(biāo)率為84.3%,且補(bǔ)充劑量400μg需要16周,而補(bǔ)充劑量≥600μg需要8周,即可有90%以上孕婦可達(dá)此標(biāo)準(zhǔn)。結(jié)論不同年齡、文化程度、家庭月收入間,孕婦紅細(xì)胞葉酸水平不同。應(yīng)依據(jù)不同紅細(xì)胞葉酸水平指導(dǎo)葉酸補(bǔ)充時(shí)間及劑量。
[Abstract]:Objective to investigate the level of folic acid in erythrocyte of early pregnant women in Beijing area and to explore the appropriate time and dosage of folic acid preparation. From February 1st 2014 to January 31st 2016, a cross-sectional survey was conducted to collect demographic data of pregnant women. The level of folic acid in erythrocyte was determined by competitive binding receptor method. Results the level of folic acid in red blood cell of pregnant women was 806.5 鹵273.7 ng / mL. The level of folic acid in erythrocyte was significantly different among different age groups (P 0.001). The folic acid level of pregnant women with higher education level was higher than that of the pregnant women with higher education level. The pregnant women with family income of 10 000 yuan per month were significantly higher than those of other groups (P 0.001). The level of folic acid in red blood cells in summer and autumn was higher than that in winter and spring. The level of folic acid in red blood cells of pregnant women increased gradually with folic acid supplementation dose (P = 0.001g / mL). The reference value was 1180nmol / L ~ 521 ng 路mL ~ (-1). The rate of reaching the standard level of folic acid in the first trimester of pregnancy was 84.3 and the supplementation dose of 400 渭 g took 16 weeks, and the supplementation of more than 600 渭 g took 8 weeks. More than 90% pregnant women can reach this standard. Conclusion different age, education level, family monthly income. Maternal erythrocyte folic acid level is different. According to different erythrocyte folic acid level guide folic acid supplementation time and dosage.
【作者單位】： 北京市海淀區(qū)婦幼保健院;
【分類(lèi)號(hào)】：R715.3
【正文快照】： 神經(jīng)管畸形(neural tube defects,NTDs)是嚴(yán)重的出生缺陷,給家庭及社會(huì)造成較大精神壓力和經(jīng)濟(jì)負(fù)擔(dān)[1]。研究證實(shí)母親葉酸狀況與神經(jīng)管畸形存在相關(guān)性[2],葉酸補(bǔ)充可降低神經(jīng)管畸形初發(fā)及再發(fā)比例[3-4],在預(yù)防神經(jīng)管畸形上具有重要作用。DALY等[5]提出以紅細(xì)胞葉酸水平作為葉

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1 滕越;胡京苗;董珊;張利霞;盧新;楊海珊;;北京地區(qū)孕早期婦女紅細(xì)胞葉酸水平及適宜葉酸補(bǔ)充時(shí)間劑量[J];衛(wèi)生研究;2017年04期

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本文編號(hào)：1439962