本文關鍵詞：GnRH拮抗劑方案中HCG扳機時機對胚胎的影響　出處：《現(xiàn)代婦產科進展》2017年03期 　論文類型：期刊論文

  更多相關文章： GnRH拮抗劑 HCG扳機時機 超促排卵 體外受精-胚胎移植

【摘要】：目的:探討促性腺激素釋放激素拮抗劑(GnRH antagonist)方案超促排卵過程中推遲人絨毛膜促性腺激素(HCG)扳機時機對胚胎質量及妊娠率等的影響。方法:回顧性分析2015年1月至12月在我院接受體外受精-胚胎移植(IVF-ET)助孕的不孕癥患者183例,均采用GnRH拮抗劑促排方案,于月經周期第2天啟用促性腺激素(Gn),當有卵泡平均直徑達到14mm,加用GnRH拮抗劑。按照傳統(tǒng)HCG扳機時機(有3個≥17mm卵泡)與推遲1天扳機分為2組:早期HCG組(149例)和晚期HCG組(34例),比較兩組數(shù)據(jù)。結果:HCG扳機日,晚期HCG組≥15mm的卵泡數(shù)明顯多于早期HCG組(P=0.026)。晚期HCG組Gn使用天數(shù)及Gn使用總量均明顯高于早期HCG組(P=0.000,P=0.012)。妊娠結局方面,晚期HCG組較早期HCG組具有更高的妊娠率(76.00%vs 50.45%,P=0.020)。兩組受精率、繼續(xù)妊娠率、流產率、異位妊娠率均無顯著差異(P0.05)。結論:GnRH拮抗劑促排方案中,適當推遲HCG扳機時間不影響胚胎質量和妊娠率,可以推行。
[Abstract]:Objective: to investigate the delay of human chorionic gonadotropin (HCG) during hyperstimulation of ovulation by gonadotropin releasing hormone antagonist (GnRH antagonistist). Effects of trigger timing on embryo quality and pregnancy rate. Methods: IVF-ETs received in our hospital from January 2015 to December were retrospectively analyzed. 183 cases of infertility assisted pregnancy. The gonadotropin gonadotropin was used on the second day of menstrual cycle, and the mean diameter of follicles was 14mm. According to the traditional HCG trigger timing (3 鈮，

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