本文關鍵詞：中藥與來曲唑在腎虛血瘀型排卵障礙性不孕癥患者中的聯(lián)合應用　出處：《中國實驗方劑學雜志》2015年13期 　論文類型：期刊論文

  更多相關文章： 中藥周期療法 來曲唑 腎虛血瘀型 排卵障礙性不孕癥

【摘要】：目的:探討中藥周期療法與來曲唑在腎虛血瘀型排卵障礙性不孕癥患者中的聯(lián)合應用價值。方法:將92例腎虛血瘀型排卵障礙性不孕癥患者隨機按數(shù)字表分為治療組和對照組各46例,對照組患者采用來曲唑的臨床藥物治療,治療組患者則在對照組治療的基礎上加用中藥周期療法的聯(lián)合治療方案,并分別對兩組患者的臨床治療情況及血清睪酮(T),雌二醇(E2),黃體生成素(LH),卵泡刺激素(FSH)的含量進行比較和分析。結果:與對照組相比,研究組的痊愈率50.00%(23/46),總有效率91.30%(42/46)均顯著提升;研究組治療后的主卵泡直徑(19.89±3.25)mm,子宮內膜厚度(9.72±1.86)mm均明顯增加;研究組的排卵率76.09%,妊娠率45.65%,活胎率90.48%均明顯提高,而流產率9.52%則明顯降低;研究組治療后的E2(240.26±58.72)pmol·L-1,FSH(16.23±4.25)U·L-1水平均明顯提高,而T(1.69±0.30)nmol·L-1,LH(24.35±6.18)U·L-1,LH/FSH(1.51±0.73)水平則明顯降低;研究組治療后的中醫(yī)證候積分(5.36±1.20)分明顯將低;研究組中醫(yī)證候療效達到臨床痊愈標準的比率54.35%(25/46)明顯提高,總有效率95.65%(44/46)顯著改善,差別均具有統(tǒng)計學意義(P0.05)。結論:中藥周期療法聯(lián)合來曲唑對于腎虛血瘀型排卵障礙性不孕癥相關臨床癥狀的改善以及臨床治療效果的提升均具有積極的促進作用,可作為腎虛血瘀型排卵障礙性不孕癥臨床治療的理想方案予以推廣。
[Abstract]:Objective: to explore the combined application value of periodic therapy of traditional Chinese medicine and letrozole in infertile patients with ovulation disorder of kidney deficiency and blood stasis type. Ninety-two patients with ovulatory disorders of kidney deficiency and blood stasis type were randomly divided into treatment group (n = 46) and control group (n = 46). The patients in the control group were treated with letrozole and the patients in the treatment group were treated with the combination of Chinese medicine cycle therapy on the basis of the treatment of the control group. The clinical treatment and serum testosterone, estradiol E _ (2) and luteinizing hormone (LH) of the two groups were also studied. Results: compared with the control group, the recovery rate of the study group was 50.00-23 / 46). The total effective rate of 91.30g / 42 / 46) was significantly increased. The diameter of main follicle and endometrial thickness were 19.89 鹵3.25mm and 9.72 鹵1.86mm, respectively. In the study group, the ovulation rate was 76.09, the pregnancy rate was 45.65, the live fetus rate was 90.48%, and the abortion rate was 9.52%. In the study group, the levels of E2V 240.26 鹵58.72 pmol 路L -1 FSHN 16.23 鹵4.25 U 路L -1 were significantly increased after treatment. However, the level of TX 1.69 鹵0.30nmol 路L -1 LHN 24.35 鹵6.18 U 路L -1 LH / FSH 1.51 鹵0.73) decreased significantly. After treatment, the score of TCM syndromes in the study group was 5.36 鹵1.20, and the score was significantly lower than that in the control group. In the study group, the rate of curative effect of TCM syndromes up to the standard of clinical cure was 54.35% / 46) and the total effective rate was 95.65% / 44% (46%). The difference was statistically significant (P0.05). Conclusion: Chinese medicine cycle therapy combined with letrozole has a positive effect on the improvement of clinical symptoms and the improvement of clinical treatment effect of ovulatory disorder of kidney deficiency and blood stasis type. It can be popularized as an ideal treatment for ovulatory infertility with kidney deficiency and blood stasis.
【作者單位】： 華中科技大學同濟醫(yī)學院附屬武漢市普愛醫(yī)院;湖北省婦幼保健院;
【基金】：2004年武漢市衛(wèi)生局基金項目(武衛(wèi)[2004]241)
【分類號】：R711.6
【正文快照】： 近年來我國女性的排卵障礙性不孕人數(shù)逐年增多,排卵障礙導致不孕的發(fā)生率由20%上升至現(xiàn)在的40%。目前,不孕癥已成為全球醫(yī)學界廣泛關注和研究的熱點與難點,不孕癥往往是指患者存在正常性生活,并且在未經避孕的前提下一年未發(fā)生妊娠[1]。據(jù)不完全統(tǒng)計,我國每年大約有10%~15%的

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