本文關(guān)鍵詞：血清和肽素、sFlt-1及AVP在子癇前期患者中的水平變化及其相關(guān)性　出處：《山東醫(yī)藥》2017年13期 　論文類型：期刊論文

  更多相關(guān)文章： 妊娠期高血壓疾病 子癇前期 和肽素 可溶性血管內(nèi)皮生長(zhǎng)因子受體 精氨酸加壓素

【摘要】：目的探討血清和肽素(CPT)、可溶性血管內(nèi)皮生長(zhǎng)因子受體1(sFlt-1)、精氨酸加壓素(AVP)在子癇前期(PE)患者中的水平變化及其相關(guān)性。方法收集妊娠期高血壓患者(HT組)11例,早發(fā)型PE患者(E-PE組)12例,晚發(fā)型PE患者(L-PE組)27例。選擇同期在本院正常產(chǎn)檢并分娩的60例健康孕婦作為對(duì)照組,其中晚期妊娠患者(L-NT組)40例、早期妊娠患者(E-NT組)20例。采用ELISA法檢測(cè)各組血清中CPT、sFlt-1、AVP水平,分析血清CPT水平與sFlt-1、AVP、年齡、收縮壓、舒張壓、胎兒體質(zhì)量、發(fā)病孕周的相關(guān)性。結(jié)果 E-PE組、L-PE組間的取樣孕周均小于L-NT組,且E-PE組的取樣孕周小于L-PE組,差異有統(tǒng)計(jì)學(xué)意義(P均0.05);但E-NT組的取樣孕周與E-PE組的取樣孕周比較,P0.05;HT組、E-PE組及L-PE組血清中CPT、sFlt-1、AVP水平均高于LNT組(P均0.05);E-PE組血清中CPT、sFlt-1、AVP水平高于E-NT組(P均0.05);血清CPT與sFlt-1、AVP、年齡、SBP、DBP均呈正相關(guān)(r分別為0.064、0.330、0.001、0.346、0.673、0.622,P均0.01),而與胎兒體質(zhì)量和發(fā)病孕周呈負(fù)相關(guān)(r分別為-0.423、-0.375,P均0.01)。結(jié)論 PE患者血清中CPT、sFlt-1、AVP水平升高,血清CPT與AVP、sFlt-1呈正相關(guān)。
[Abstract]:Objective to investigate the expression of soluble vascular endothelial growth factor receptor (VEGFR) in serum and peptide (CPT). The level of arginine vasopressin (AVP) in patients with preeclampsia (PEI) and its correlation. Methods 11 cases of hypertensive disorder complicating pregnancy were collected. There were 12 cases of early type PE and 27 cases of late type PE. 60 healthy pregnant women who had normal delivery and normal delivery in our hospital were selected as control group. There were 40 cases of L-NT in late pregnancy group and 20 cases of E-NT group in early pregnancy. The serum levels of CPTsFlt-1AVP in each group were detected by ELISA method. To analyze the correlation between serum CPT level and sFlt-1 AVP, age, systolic blood pressure, diastolic blood pressure, fetal body mass and gestational age. The gestational weeks of L-PE group were smaller than that of L-NT group, and the gestational weeks of E-PE group were smaller than L-PE group (P < 0.05). But the sampling gestational weeks in E-NT group were compared with those in E-PE group (P 0.05). The levels of serum CPTsFlt-1AVP in HT group and L-PE group were higher than those in LNT group (P < 0.05). The serum levels of CPTsFlt-1 AVP in E-PE group were higher than those in E-NT group (P 0.05). There was a positive correlation between serum CPT and sFlt-1 AVP, age SBP, DBP (r = 0.064 0. 330 0. 001 + 0. 344 鹵0. 673, P < 0. 05). 0.622 P was 0. 01%, but negatively correlated with fetal body mass and gestational week, r = -0.423 ~ 0.375, respectively. Conclusion the level of serum CPTT sFlt-1AVP in PE patients is higher than that in PE patients, and there is a positive correlation between serum CPT and AVPsFlt-1.
【作者單位】： 南方醫(yī)科大學(xué)附屬深圳市婦幼保健院;南方醫(yī)科大學(xué)第一臨床醫(yī)學(xué)院;南方醫(yī)科大學(xué)深圳醫(yī)院;
【分類號(hào)】：R714.244
【正文快照】： 第一臨床醫(yī)學(xué)院;3南方醫(yī)科大學(xué)深圳醫(yī)院)子癇前期(PE)是妊娠期特有疾病,發(fā)病率為3.0%~8.4%,孕產(chǎn)婦病死率為9%~25%,是全球范圍內(nèi)嚴(yán)重影響母兒健康的疾病[1]。根據(jù)在妊娠34周前后是否發(fā)病,PE被分為早發(fā)型PE和晚發(fā)型PE�，F(xiàn)一致認(rèn)為早發(fā)型PE與胎盤功能障礙相關(guān),病情明顯更為嚴(yán)重,

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