本文關(guān)鍵詞：門(mén)冬胰島素聯(lián)合地特胰島素治療妊娠糖尿病的療效分析　出處：《中外醫(yī)療》2016年35期 　論文類(lèi)型：期刊論文

  更多相關(guān)文章： 妊娠糖尿病 門(mén)冬胰島素 地特胰島素 臨床效果

【摘要】：目的探討門(mén)冬胰島素聯(lián)合地特胰島素治療妊娠糖尿病的臨床療效。方法方便選擇該院自2014年1月—2016年6月收治的74例妊娠糖尿病患者為研究對(duì)象,并按照隨機(jī)數(shù)字表法分為對(duì)照組和觀(guān)察組,每組各37例。對(duì)照組患者使用生物合成人胰島素注射液治療(三餐前30 min皮下注射),觀(guān)察組患者接受門(mén)冬胰島素(三餐前進(jìn)食前皮下注射)+地特胰島素(睡前皮下注射)治療。比較兩組患治療前后空腹血糖(FBG)、餐后2 h血糖(2 h PG)、糖化血紅蛋白(Hb A1c)、血糖達(dá)標(biāo)時(shí)間及低血糖發(fā)生率差異。結(jié)果治療前兩組間FBG[對(duì)照組和觀(guān)察組分別為(9.57±3.24)mmol/L vs(9.54±2.68)mmol/L,t=0.526]、2 h PG[對(duì)照組和觀(guān)察組分別為(15.43±3.58)mmol/L vs(15.54±2.52)mmol/L,t=-0.632]和Hb A1c[對(duì)照組和觀(guān)察組分別為(10.54±1.25)%vs(10.48±1.32)%,t=0.695]差異無(wú)統(tǒng)計(jì)學(xué)意義(P0.05),治療后兩組FBG[對(duì)照組和觀(guān)察組分別為(6.78±2.15)mmol/L vs(5.43±1.64)mmol/L,t=0.3.423]、2 h PG[對(duì)照組和觀(guān)察組分別為(11.36±2.46)mmol/L vs(9.23±1.54)mmol/L,t=3.695]和Hb A1c[對(duì)照組和觀(guān)察組分別為(7.65±1.54)%vs(6.23±1.63)%,t=3.452]較治療前均明顯降低,與治療前相比差異無(wú)統(tǒng)計(jì)學(xué)意義(P0.05),且觀(guān)察組患者較對(duì)照組下降更為明顯(與對(duì)照組治療后相比,P0.05)。治療期間觀(guān)察組患者血糖達(dá)標(biāo)時(shí)間(6.24±1.43)d和低血糖發(fā)生率(5.41%)均明顯低于對(duì)照組[分別為(8.56±2.14)d、(18.9%)]患者,差異有統(tǒng)計(jì)學(xué)意義(t=3.562,χ2=3.446,P0.05)。結(jié)論門(mén)冬胰島素聯(lián)合地特胰島素治療妊娠糖尿病臨床效果顯著,低血糖發(fā)生率低,值得在臨床中推廣應(yīng)用。
[Abstract]:Objective to investigate the clinical efficacy of insulin aspart insulin detemir treatment of gestational diabetes mellitus. Methods to facilitate the selection of the hospital since January 2014 June 2016 were treated 74 cases of gestational diabetes patients as the research object, and randomly divided into control group and observation group, 37 cases in each group. The control group was treated with Biosynthetic Human Insulin Injection treatment (before meals 30 min subcutaneous injection), patients in the observation group received insulin aspart (meals intake before subcutaneous injection of insulin detemir (+) before subcutaneous injection) treatment. Compare the two groups before and after treatment with fasting blood glucose (FBG), 2 h postprandial blood glucose (2 h PG), glycosylated hemoglobin (Hb A1c), blood glucose time and hypoglycemia the incidence of the difference between the two groups before treatment. Results FBG[observation group and the control group respectively (9.57 + 3.24) mmol/L vs (9.54 + 2.68) mmol/L, t=0.526] 2, H PG [the observation group and the control group respectively (15. 43鹵3.58)mmol/L vs(15.54鹵2.52)mmol/L,t=-0.632]鍜孒b A1c[瀵圭収緇勫拰瑙傚療緇勫垎鍒負(fù)(10.54鹵1.25)%vs(10.48鹵1.32)%,t=0.695]宸紓鏃犵粺璁″鎰忎箟(P0.05),娌葷枟鍚庝袱緇凢BG[瀵圭収緇勫拰瑙傚療緇勫垎鍒負(fù)(6.78鹵2.15)mmol/L vs(5.43鹵1.64)mmol/L,t=0.3.423],2 h PG[瀵圭収緇勫拰瑙傚療緇勫垎鍒負(fù)(11.36鹵2.46)mmol/L vs(9.23鹵1.54)mmol/L,t=3.695]鍜孒b A1c[瀵圭収緇勫拰瑙傚療緇勫垎鍒負(fù)(7.65鹵1.54)%vs(6.23鹵1.63)%,t=3.452]杈冩不鐤楀墠鍧囨槑鏄鵑檷浣，

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