本文關(guān)鍵詞：精液優(yōu)化處理前后精子畸形率的變化及其對(duì)人工授精結(jié)局的影響　出處：《交通醫(yī)學(xué)》2016年06期 　論文類型：期刊論文

  更多相關(guān)文章： 畸形精子 人工授精 精液優(yōu)化處理

【摘要】：目的 :比較精子畸形率在精液優(yōu)化處理前后的變化及對(duì)IUI妊娠結(jié)局的影響。方法:選擇進(jìn)行IUI助孕患者精液優(yōu)化處理前后采用Diff-Quik染色法檢測(cè)精子畸形率,分析精子形態(tài)在優(yōu)化處理前后的變化及其與IUI臨床妊娠率的關(guān)系。結(jié)果:132個(gè)IUI治療周期中精子畸形率高于正常值的有95個(gè)周期,精液優(yōu)化處理前后平均正常形態(tài)精子率(2.69±1.75)%vs(3.62±2.50)%,平均精子畸形指數(shù)(SDI)1.32±0.15 vs 1.31±0.19,平均畸形精子指數(shù)(TZI)1.36±0.15 vs 1.36±0.19;精液優(yōu)化處理后正常形態(tài)精子比率明顯高于精液優(yōu)化處理前(P0.05),精子畸形指數(shù)及畸形精子指數(shù)優(yōu)化處理前后比較,差異無統(tǒng)計(jì)學(xué)意義(P0.05)。精液優(yōu)化處理后正常形態(tài)精子率(normal morphology sperm rate,NMSR)仍未達(dá)標(biāo)的72個(gè)治療周期中,IUI臨床妊娠12例,臨床妊娠率16.67%;處理后精子正常形態(tài)率達(dá)標(biāo)的60個(gè)治療周期中,IUI臨床妊娠7例,臨床妊娠率11.67%,兩組差異無統(tǒng)計(jì)學(xué)意義(P0.05)。結(jié)論:密度梯度離心法處理精液后可以顯著降低精子畸形率,但密度梯度離心處理后精子畸形率的高低與IUI妊娠結(jié)局無明顯相關(guān)性。
[Abstract]:Objective: to compare the changes of sperm malformation rate before and after semen optimization and its effect on pregnancy outcome of IUI. Sperm malformation rate was detected by Diff-Quik staining before and after optimal treatment of semen with IUI. The changes of sperm morphology before and after optimal treatment and the relationship between sperm morphology and clinical pregnancy rate of IUI were analyzed. Results: in 132 cycles of IUI treatment, the abnormal rate of sperm was higher than the normal value for 95 cycles. The average normal sperm rate before and after optimized semen treatment was 2.69 鹵1.75 鹵3.62 鹵2.50%. The average sperm malformation index (SDI) was 1.32 鹵0.15 vs 1.31 鹵0.19. The mean sperm index of deformity was 1.36 鹵0.15 vs 1.36 鹵0.19; The percentage of normal sperm after optimized treatment was significantly higher than that of P0.05before the optimized treatment. The sperm deformity index and sperm deformity index were compared before and after the optimization treatment. There was no significant difference in normal morphology sperm rate. There were 12 cases of IUI pregnancy in 72 treatment cycles, and the clinical pregnancy rate was 16.67%. There were 7 cases of clinical pregnancy and 11.67% cases of clinical pregnancy in the 60 treatment cycles in which the normal morphology rate of spermatozoa was up to standard after treatment. There was no significant difference between the two groups (P 0.05). Conclusion: the sperm deformity rate can be significantly reduced by density gradient centrifugation. However, there was no significant correlation between sperm abnormality rate and pregnancy outcome of IUI after density gradient centrifugation.
【作者單位】： 南通大學(xué)附屬醫(yī)院生殖醫(yī)學(xué)中心;
【分類號(hào)】：R714.8
【正文快照】： 對(duì)于男性而言,產(chǎn)生足夠數(shù)量的精子是使女方受孕的前提條件。目前,精液常規(guī)分析是男性生育功能評(píng)估一項(xiàng)重要參考依據(jù),精子形態(tài)分析是精液常規(guī)分析中的一項(xiàng)重要指標(biāo)。然而精子功能受損被認(rèn)為是導(dǎo)致男性不育的主要原因[1],精子功能的受損往往與精子形態(tài)異常相關(guān)。有研究認(rèn)為,精子

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