本文關(guān)鍵詞：胚胎發(fā)育潛能低下患者的凍融策略選擇　出處：《中國(guó)性科學(xué)》2016年11期 　論文類型：期刊論文

  更多相關(guān)文章： 胚胎發(fā)育潛能 凍融周期 早期流產(chǎn)

【摘要】：目的:比較胚胎發(fā)育潛能低下的患者在凍融周期中移植不同時(shí)期胚胎的妊娠結(jié)局,以優(yōu)化其凍融策略。方法:回顧性分析2015年1月至10月于我院生殖醫(yī)學(xué)中心治療的57例常規(guī)體外受精(IVF)周期或卵胞漿內(nèi)單精子注射(ICSI)周期中胚胎發(fā)育潛能低下患者的凍融周期臨床資料。根據(jù)移植胚胎的時(shí)期分為分裂胚移植組(n=35)及囊胚移植組(n=22),比較兩組的臨床妊娠率、種植率及早期流產(chǎn)率。結(jié)果:凍融周期中,Day3分裂胚移植組與Day5囊胚移植組相比,臨床妊娠率(65.71%vs.63.63%)和種植率(50.00%vs.52.27%)相近;早期流產(chǎn)率雖無(wú)統(tǒng)計(jì)學(xué)差異,但分裂胚移植組的早期流產(chǎn)率有明顯高于囊胚移植組的趨勢(shì)(8.7%vs.0)。結(jié)論:凍融周期中,對(duì)胚胎發(fā)育潛能低下的患者建議優(yōu)選囊胚移植,以降低早期流產(chǎn)風(fēng)險(xiǎn)。本研究結(jié)果需擴(kuò)大樣本后進(jìn)一步探討,為優(yōu)化凍融周期的妊娠結(jié)局提供新思路。
[Abstract]:Objective: to compare the pregnancy outcomes of embryo transplants in different stages in freeze-thaw cycles in patients with low embryonic development potential. Methods: from January 2015 to October, 57 cases of IVF cycles or intracytoplasmic sperm injection (ICSI) were analyzed retrospectively. Clinical data of frozen-thawing cycle in patients with hypodevelopment of embryo development during ICSI cycle. According to the period of embryo transfer, they were divided into two groups: divided into divided embryo transfer group and blastocyst transplantation group (n ~ (35)) and blastocyst transplantation group (n ~ (22)). Results: the clinical pregnancy rate, implantation rate and early abortion rate of the two groups were compared with those of the Day5 blastocyst transplantation group. The clinical pregnancy rate (65.71 vs 63.63) and the planting rate (50.00v s.52.27) were similar. Although there was no statistical difference in the rate of early abortion, the rate of early abortion in the split embryo transplantation group was significantly higher than that in the blastocyst transplantation group. Conclusion: in the freeze-thaw cycle, the rate of early abortion is 8.7vs.0. In order to reduce the risk of early abortion, it is suggested to select blastocysts for patients with low embryonic development potential. The results of this study need to be further explored after expanding the sample to provide a new idea for optimizing the pregnancy outcome of freezing and thawing cycle.
【作者單位】： 南京大學(xué)醫(yī)學(xué)院附屬鼓樓醫(yī)院生殖醫(yī)學(xué)中心;
【基金】：國(guó)家自然科學(xué)基金培育項(xiàng)目(021414380067) 江蘇省南京市醫(yī)學(xué)科技發(fā)展課題(YKK15074) CREATE-默克雪蘭諾中國(guó)生殖醫(yī)學(xué)研究基金
【分類號(hào)】：R714.8
【正文快照】： 胚胎凍融技術(shù)作為輔助生殖領(lǐng)域中的一項(xiàng)常規(guī)技術(shù),方法成熟,結(jié)果穩(wěn)定,是臨床治療中常規(guī)的保存生育力方法,既可減少IVF患者反復(fù)接受激素刺激的超排卵治療,又能夠有效的解決剩余胚胎的去向問(wèn)題,目前該技術(shù)已經(jīng)成為唯一被北美生殖醫(yī)學(xué)委員會(huì)認(rèn)可的臨床可開(kāi)展的生育力保存方法[1-5]

【相似文獻(xiàn)】

相關(guān)期刊論文 前10條

1 曹彤;原核期合子發(fā)育潛能與原核方位的關(guān)系[J];國(guó)外醫(yī)學(xué)(計(jì)劃生育分冊(cè));2004年04期

2 陸士中;冷藏不影響人受精卵的發(fā)育潛能[J];國(guó)外醫(yī)學(xué).婦產(chǎn)科學(xué)分冊(cè);1987年03期

3 王嫻靜;孫曉溪;;原核期細(xì)胞形態(tài)學(xué)預(yù)測(cè)胚胎發(fā)育潛能[J];國(guó)外醫(yī)學(xué)(計(jì)劃生育/生殖健康分冊(cè));2007年02期

4 王平;董衛(wèi)國(guó);湯紹遷;;揮發(fā)性有機(jī)物對(duì)孕婦胚胎發(fā)育潛能的影響及控制[J];中國(guó)醫(yī)學(xué)裝備;2013年09期

5 李建華;張水文;郭軍紅;徐野;;時(shí)差成像監(jiān)測(cè)在評(píng)估胚胎發(fā)育潛能中的作用[J];中國(guó)優(yōu)生與遺傳雜志;2014年02期

6 蒲艷;黃國(guó)寧;王亞平;;體外培養(yǎng)胚胎發(fā)育潛能的非損傷性評(píng)價(jià)方法[J];實(shí)用婦產(chǎn)科雜志;2007年08期

7 邱卓琳;李紅;毛向明;羅琛;張為青;全松;;不同劑量促排卵激素對(duì)昆明小鼠卵子及胚胎發(fā)育潛能的影響[J];廣東醫(yī)學(xué);2012年03期

8 林楠;馮云;;代謝組學(xué)預(yù)測(cè)卵子質(zhì)量與胚胎發(fā)育潛能研究進(jìn)展[J];中國(guó)實(shí)用婦科與產(chǎn)科雜志;2012年07期

9 陸小n，

本文編號(hào)：1389649