本文關(guān)鍵詞：三種促排卵方案對(duì)卵巢儲(chǔ)備力低下患者助孕效果比較　出處：《現(xiàn)代婦產(chǎn)科進(jìn)展》2016年11期 　論文類型：期刊論文

  更多相關(guān)文章： 卵巢儲(chǔ)備低下 微刺激 黃體期促排卵 超短方案 體外受精

【摘要】：目的:探討卵巢儲(chǔ)備力低下患者行體外受精/卵胞漿內(nèi)單精子顯微注射-胚胎移植(IVF/ICSI-ET)助孕時(shí)較理想的超促排卵方案。方法:將302例行IVF/ICSI-ET助孕的卵巢儲(chǔ)備力低下患者分為3組:微刺激方案組(A組,98例)、黃體期促排卵方案組(B組,62例)和超短方案組(C組,142例),比較3組的一般情況、周期取消率、總促性腺激素釋放激素(Gn)使用天數(shù)(Gn天數(shù))、人絨毛膜促性腺激素(HCG)日血雌二醇(E_2)、促黃體生成素(LH)、孕酮(P)及子宮內(nèi)膜厚度、平均獲卵數(shù)、受精率、形成胚胎率、優(yōu)質(zhì)胚胎率、臨床妊娠率、生化妊娠率。結(jié)果:A組的周期取消率均明顯高于B、C兩組(P0.05);A組的總Gn天數(shù)最短,C組的總Gn天數(shù)最長(zhǎng)(P0.05);A組的HCG日子宮內(nèi)膜厚度低于B、C組,但差異無統(tǒng)計(jì)學(xué)意義;A組的HCG日E_2水平、平均獲卵數(shù)均低于B、C兩組,C組的HCG日LH水平均低于A、B兩組(P0.05)。3組的一般情況、正常受精率、成胚率、優(yōu)胚率、臨床妊娠率、生化妊娠率均無統(tǒng)計(jì)學(xué)差異。結(jié)論:超短方案可能是較好的卵巢儲(chǔ)備力低下超促排卵方案,同時(shí)黃體期促排卵亦不失為一種新的有效促排卵方案。
[Abstract]:Objective: to investigate in vitro fertilization / intracytoplasmic sperm microinjection (IVF / ICSI-ETT) in patients with low ovarian reserve. Methods: 302 patients with IVF/ICSI-ET were divided into three groups: group A and group A. There were 98 cases of ovulation promotion in luteal phase, 62 cases in group B and 142 cases in group C in ultrashort group. The general situation of group 3 and the rate of cycle cancellation were compared. Total gonadotropin releasing hormone (Gn) was used for days and HCG was used for days. Serum estradiol (E _ (2)) and luteinizing hormone (LH) were observed on the day of HCG (human chorionic gonadotropin) (HCG). P) and endometrial thickness, average number of eggs obtained, fertilization rate, embryo formation rate, high quality embryo rate, clinical pregnancy rate and biochemical pregnancy rate. Results the rate of cycle cancellation in group A was significantly higher than that in group B. Group C, P 0.05; Group A had the shortest total Gn days and group C had the longest total Gn days (P0.05); The thickness of endometrium in group A was lower than that in group C on HCG day, but the difference was not statistically significant. The average number of eggs obtained in group A was lower than that in group C (HCG day LH), which was lower than that in group A (group A) and group B (P 0.05.3), and the normal fertilization rate was also lower than that in group A (group A). The rate of embryo formation, the rate of superior embryo, the rate of clinical pregnancy and the rate of biochemical pregnancy were not statistically different. Conclusion: ultrashort regimen may be a better regimen of ovarian reserve capacity and hyperstimulation of ovulation. At the same time, ovulation promotion in luteal phase is also a new effective ovulation promotion program.
【作者單位】： 青島大學(xué)附屬醫(yī)院生殖醫(yī)學(xué)科;
【分類號(hào)】：R714.8
【正文快照】： 育齡女性卵巢儲(chǔ)備功能下降(diminished ovarian reserve,DOR)是指卵巢產(chǎn)生卵母細(xì)胞的能力和質(zhì)量下降,從而導(dǎo)致生育能力低下,約占不孕不育癥行輔助生殖技術(shù)(assisted reproductive technology,ART)的10%。DOR患者在行IVF/ICSI-ET助孕過程中常出現(xiàn)卵巢低反應(yīng)(poor ovarian respo

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