本文關(guān)鍵詞：婦科原發(fā)性小細(xì)胞癌八例臨床分析　出處：《中華腫瘤防治雜志》2016年03期 　論文類型：期刊論文

  更多相關(guān)文章： 婦科腫瘤 小細(xì)胞癌 聯(lián)合治療 預(yù)后

【摘要】：目的婦科原發(fā)性小細(xì)胞癌病例罕見(jiàn),預(yù)后差。結(jié)合北京大學(xué)第三醫(yī)院病例探討婦科原發(fā)性小細(xì)胞癌的發(fā)病特點(diǎn)以及診斷治療方案。方法回顧性分析2006-01-01-2015-08-31北京大學(xué)第三醫(yī)院收治的經(jīng)病理確診的8例婦科原發(fā)性小細(xì)胞癌患者的臨床特征、治療方案以及預(yù)后。結(jié)果患者年齡16~71歲,中位年齡43歲。常見(jiàn)癥狀包括陰道異常出血、腹痛、腹部包塊等。診斷主要依靠手術(shù)病理確診,其中宮頸小細(xì)胞癌ⅠB 1期2例,ⅠB 2期2例,ⅢB期1例;卵巢小細(xì)胞癌ⅢC期1例;子宮內(nèi)膜小細(xì)胞癌Ⅳ期2例。治療方案包括手術(shù)、化療和放療。手術(shù)方式參照相應(yīng)部位腫瘤的治療原則,有5例行廣泛子宮切除術(shù),2例行腫瘤細(xì)胞減滅術(shù),1例因高齡伴高血壓未行手術(shù)。7例手術(shù)患者中有3例接受術(shù)前化療,7例術(shù)后均輔助化療,有5例輔助術(shù)后放療。隨訪至2015-12-20,無(wú)患者失訪。有3例生存,分別隨訪22、22和56個(gè)月;5例死亡,生存期分別為2、8、10、22和31個(gè)月�；颊呒膊o(wú)進(jìn)展生存時(shí)間(progression-free survival,PFS)為0.3~56個(gè)月,中位PFS為15個(gè)月,總生存時(shí)間(overall survival,OS)為2~56個(gè)月,中位OS為22個(gè)月。結(jié)論婦科小細(xì)胞癌術(shù)前影像學(xué)檢查常有淋巴結(jié)轉(zhuǎn)移,其確診依靠組織病理學(xué)檢查。該腫瘤預(yù)后差,手術(shù)是早期病變的主要治療手段,晚期病例宜采用手術(shù)、化療和放療相結(jié)合的綜合治療。
[Abstract]:Objective Primary small cell carcinoma of gynecology is rare. The prognosis was poor. To discuss the characteristics of gynecological primary small cell carcinoma and its diagnosis and treatment with the case of Peking University third Hospital. Methods retrospective analysis of 2006-01-2015-08-31 North China. Clinical features of 8 patients with gynecological primary small cell carcinoma admitted to the third Hospital of Beijing University. Results the age of the patients was 1671 years old and the median age was 43 years old. The common symptoms included abnormal vaginal bleeding abdominal pain abdominal mass and so on. The diagnosis was mainly based on surgery and pathology. There were 2 cases of small cell carcinoma of the cervix in stage 鈪，

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