本文關(guān)鍵詞：多烯磷脂酰膽堿對妊娠期肝內(nèi)膽汁淤積癥的治療效果及對妊娠結(jié)局的影響　出處：《中國婦幼保健》2016年24期 　論文類型：期刊論文

  更多相關(guān)文章： 多烯磷脂酰膽堿 妊娠期肝內(nèi)膽汁淤積癥 妊娠結(jié)局

【摘要】：目的探討多烯磷脂酰膽堿對妊娠期肝內(nèi)膽汁淤積癥的治療效果及對妊娠結(jié)局的影響。方法選擇2015年2月-2016年2月接診的妊娠期肝內(nèi)膽汁淤積癥患者80例,通過隨機數(shù)表法分為觀察組和對照組各40例,對照組患者給予熊去氧膽酸+腺苷蛋氨酸治療,觀察組患者在此基礎(chǔ)上加用多烯磷脂酰膽堿。觀察兩組患者治療前、后肝功能、瘙癢積分變化及瘙癢、黃疸消失時間,并比較兩組患者妊娠結(jié)局及新生兒結(jié)局。結(jié)果治療后,觀察組丙氨酸轉(zhuǎn)氨酶(ALT)、谷草轉(zhuǎn)氨酶(AST)、血清總膽汁酸(TBA)均低于對照組,瘙癢積分(1.01±0.23)低于對照組的(1.95±0.27),瘙癢消失、黃疸消失時間均比對照組短,差異均有統(tǒng)計學(xué)意義(P0.05);觀察組分娩孕周比對照組長,剖宮產(chǎn)率27.5%低于對照組的40.0%,差異有統(tǒng)計學(xué)意義(P0.05);觀察組宮內(nèi)窘迫、早產(chǎn)、新生兒窒息、產(chǎn)后出血的發(fā)生率均比對照組低,新生兒體重高于對照組,差異有統(tǒng)計學(xué)意義(P0.05)。結(jié)論在妊娠期肝內(nèi)膽汁淤積癥患者中,給予多烯磷脂酰膽堿的治療效果優(yōu)異,可使妊娠結(jié)局得到有效的改善,值得應(yīng)用推廣。
[Abstract]:Objective to investigate the therapeutic effect of polyenylphosphatidylcholine on intrahepatic cholestasis of pregnancy and its effect on pregnancy outcome. Methods Intrahepatic cholestasis of pregnancy was selected from February 2015 to February 2016. There were 80 cases. The patients in the control group were treated with adenosylmethionine ursodeoxycholate. The patients in the observation group were treated with polyenylphosphatidylcholine on this basis. The liver function, the change of itching score and the time of disappearance of pruritus and jaundice were observed before and after treatment in both groups. Results after treatment, the levels of alanine aminotransferase (alt), alanine aminotransferase (alt), aspartate aminotransferase (AST) and serum total bile acid (TBA) in the observation group were lower than those in the control group. The score of itching (1.01 鹵0.23) was lower than that of control group (1.95 鹵0.27). The time of disappearance of pruritus and jaundice was shorter than that of control group (P 0.05). The rate of cesarean section in the observation group was lower than that in the control group (P < 0.05), and the rate of cesarean section was lower than that in the control group (P < 0.05). The incidence of intrauterine distress, premature delivery, neonatal asphyxia and postpartum hemorrhage in the observation group was lower than that in the control group, and the weight of the newborn was higher than that in the control group. Conclusion in the patients with intrahepatic cholestasis of pregnancy, the effect of polyenylphosphatidylcholine is excellent, and the pregnancy outcome can be effectively improved. It is worth applying and popularizing.
【作者單位】： 武漢大學(xué)人民醫(yī)院鐘祥醫(yī)院;鐘祥市人民醫(yī)院;
【分類號】：R714.255
【正文快照】： 在妊娠中、晚期,妊娠期肝內(nèi)膽汁淤積癥(In-trahepatic cholestasis of pregnancy,ICP)較為常見,該病主要是由于膽汁無法良好的排除,使之在膽道內(nèi)發(fā)生淤積,導(dǎo)致患者出現(xiàn)皮膚瘙癢、黃疸、血清膽汁酸升高的癥狀[1]。該病易對胎兒造成較大影響,會引發(fā)早產(chǎn)、新生兒窒息、宮內(nèi)窘迫等

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