發(fā)布時(shí)間：2019-06-22 20:12

【摘要】：目的：探討外用重組人粒細(xì)胞巨噬細(xì)胞集落刺激因子(Granulocyte/Macrophage Colony-stimulating Factor，rhGM-CSF)及外用重組牛堿性成纖維細(xì)胞生長(zhǎng)因子（Recombinant Bovine Basic FibroblastGrowth Factor，rb-bFGF）治療兒童淺Ⅱ度燒傷創(chuàng)面的有效性及安全性。 方法：將2012年6月-2012年11月住院的淺Ⅱ度燒傷患兒45例按照抽簽法隨機(jī)分為3組，治療組分別為rhGM-CSF組20例、rb-bFGF組20例，對(duì)照組生理鹽水組5例；rhGM-CSF組予0.5μg/cm2直接涂在創(chuàng)面上，，rb-bFGF組應(yīng)用0.03ml/cm2直接均勻噴于創(chuàng)面，生理鹽水組應(yīng)用0.03ml/cm2直接均勻噴于創(chuàng)面，比較治療組與對(duì)照組創(chuàng)面愈合時(shí)間，同時(shí)監(jiān)測(cè)血常規(guī)、尿常規(guī)及肝腎功等相關(guān)指標(biāo)，檢測(cè)創(chuàng)面細(xì)菌培養(yǎng)。 結(jié)果：治療組rhGM-CSF創(chuàng)面愈合時(shí)間（8.619±0.944）d，rb-bFGF組（10.766±1.369）d,兩組較生理鹽水對(duì)照組（13.850±0.398）d明顯縮短，差異有統(tǒng)計(jì)學(xué)意義（P0.05）；rhGM-CSF創(chuàng)面愈合時(shí)間（8.619±0.944）d較rb-bFGF組（10.766±1.369）d縮短，差異具有統(tǒng)計(jì)學(xué)意義。用藥期間患兒血常規(guī)及肝腎功等相關(guān)指標(biāo)未見明顯異常，與藥物使用前相比，P＞0.05，差異無統(tǒng)計(jì)學(xué)意義，且在治療過程中，患兒無明顯不良反應(yīng)。 結(jié)論：rhGM-CSF及rb-bFGF治療淺Ⅱ度燒傷與生理鹽水相比較能有效縮短愈合時(shí)間、加快愈合速度；rhGM-CSF在加快創(chuàng)面愈合速度上較rb-bFGF更為明顯。在治療過程中患兒無明顯不良反應(yīng)，在兒童淺度燒傷創(chuàng)面的治療應(yīng)用中具有安全性。
[Abstract]:Aim: to investigate the efficacy and safety of recombinant human granulocyte macrophage colony stimulating factor (Granulocyte/Macrophage Colony-stimulating Factor,rhGM-CSF) and recombinant bovine basic fibroblast growth factor (Recombinant Bovine Basic FibroblastGrowth Factor,rb-bFGF) in the treatment of superficial second degree burn wounds in children. Methods: from June 2012 to November 2012, 45 children with superficial second degree burn were randomly divided into three groups: treatment group (n = 20), rb-bFGF group (n = 20) and control group (n = 5). RhGM-CSF group was treated with 0.5 渭 g / cm2 directly on the wound, rb-bFGF group was sprayed with 0.03ml/cm2 directly and evenly on the wound, saline group was sprayed directly and evenly on the wound, the wound healing time was compared between the treatment group and the control group, and the related indexes such as blood routine, urine routine and liver and kidney function were monitored at the same time, and the bacterial culture of the wound was detected. Results: the wound healing time of rhGM-CSF in treatment group was (8.619 鹵0.944) days, and that in BB 鈮

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