天堂国产午夜亚洲专区-少妇人妻综合久久蜜臀-国产成人户外露出视频在线-国产91传媒一区二区三区

當(dāng)前位置:主頁 > 醫(yī)學(xué)論文 > 兒科論文 >

和肽素、腦鈉肽和C-反應(yīng)蛋白在小兒先天性心臟病合并心力衰竭外周血濃度的變化及臨床意義

發(fā)布時(shí)間:2019-06-08 09:57
【摘要】:目的:探討和肽素(copeptin)、腦鈉肽(BNP)、C-反應(yīng)蛋白(CRP)在兒童先天性心臟病(CHD)伴心衰患兒外周血濃度的變化及臨床意義。 方法:66例CHD患兒分為心衰組、心衰肺炎組和無心衰組,并設(shè)肺炎對照組和健康對照組。酶聯(lián)免疫吸附法(ELISA)檢測外周血copeptin、BNP和CRP濃度,超聲心動(dòng)圖測定左心室射血分?jǐn)?shù)(LVEF)。 結(jié)果:CHD心衰肺炎組血copeptin、BNP和CRP濃度明顯高于心衰組、無心衰組、肺炎對照組和健康對照組(P0.05或0.01)。CHD心衰患兒外周血copeptin、BNP和CRP濃度高于正常對照組(P0.05或0.01),且隨心衰程度的加重而逐漸升高。CHD心衰患兒血copeptin和BNP濃度與LVEF呈明顯負(fù)相關(guān)(r=-0.602和-0.561,P0.05),CRP與LVEF無明顯相關(guān)性(P0.05)。以外周血copeptin1.92ng/ml和BNP239.50pg/ml為臨界點(diǎn)診斷CHD心衰,其ROC曲線下面積分別為0.822和0.801,特異性分別為87.5%和81.2%,敏感性分別為86.8%和89.5%,Youden指數(shù)(0.743和0.707)比較無差異(U=0.24, p0.05); copeptin和BNP的串聯(lián)試驗(yàn)與平行試驗(yàn)診斷心衰的特異性分別為94%和75%,敏感性分別為79%和95%,Youden指數(shù)分別為0.73和0.7,二者比較無差異(U=0.21,p0.05)。 結(jié)論:CHD心衰患兒外周血copeptin、BNP濃度明顯升高,且與LVEF呈現(xiàn)明顯的負(fù)相關(guān);外周血copeptin和BNP濃度可作為心衰患兒診斷、嚴(yán)重度及心功能分級的生物學(xué)標(biāo)志物。
[Abstract]:Aim: to investigate the changes and clinical significance of (copeptin), brain natriuretic peptide (BNP), C-reactive protein (CRP) in peripheral blood of children with congenital heart disease (CHD) with heart failure. Methods: 66 children with CHD were divided into three groups: heart failure group, heart failure pneumonia group and no heart failure group, and divided into pneumonia control group and healthy control group. The concentrations of copeptin,BNP and CRP in peripheral blood were measured by enzyme-linked immunosorbent assay (Elisa), and the left ventricular ejection fraction (LVEF).) was measured by echocardiography. Results: the concentrations of copeptin,BNP and CRP in CHD heart failure pneumonia group were significantly higher than those in heart failure group, no heart failure group, pneumonia control group and healthy control group (P 0.05 or 0.01). CHD). The concentrations of BNP and CRP were higher than those in the normal control group (P 0.05 or 0.001), and increased gradually with the aggravation of heart failure. There was a significant negative correlation between blood copeptin and BNP concentrations and LVEF in children with coronary heart failure (r 鈮,

本文編號(hào):2495201

資料下載
論文發(fā)表

本文鏈接:http://sikaile.net/yixuelunwen/eklw/2495201.html


Copyright(c)文論論文網(wǎng)All Rights Reserved | 網(wǎng)站地圖 |

版權(quán)申明:資料由用戶bc5bf***提供,本站僅收錄摘要或目錄,作者需要?jiǎng)h除請E-mail郵箱bigeng88@qq.com
激情图日韩精品中文字幕| 国产午夜精品在线免费看| 成人国产一区二区三区精品麻豆| 国产精品一区二区香蕉视频| 亚洲精品一区二区三区日韩| 99国产精品国产精品九九| 中文字幕五月婷婷免费| 亚洲天堂一区在线播放| 91在线播放在线播放观看| 日本最新不卡免费一区二区| 中文字幕人妻日本一区二区| 91偷拍与自偷拍精品| 欧美国产在线观看精品| 夜色福利久久精品福利| 日本办公室三级在线观看| 国产高清精品福利私拍| 日韩亚洲激情在线观看| 不卡免费成人日韩精品| 亚洲天堂有码中文字幕视频| 经典欧美熟女激情综合网| 国产精品99一区二区三区| 欧美日韩综合在线第一页| 午夜资源在线观看免费高清| 国产高清一区二区不卡| 精品国产一区二区欧美| 日本午夜免费观看视频| 精品欧美日韩一二三区| 少妇高潮呻吟浪语91| 黄男女激情一区二区三区| 69精品一区二区蜜桃视频| 男人和女人草逼免费视频| 熟女白浆精品一区二区| 隔壁的日本人妻中文字幕版| 青青操视频在线观看国产| 欧美成人高清在线播放| 神马午夜福利一区二区| 欧美二区视频在线观看| 中文字幕一区二区免费| 91人妻人人做人碰人人九色| 黄片免费观看一区二区| 后入美臀少妇一区二区|