【摘要】：目的:通過對比分析不同劑量甲潑尼龍聯(lián)合不同抑酸劑的療效及安全性,尋求治療兒童腹型過敏性紫癜的最佳治療方案。方法:選擇符合本研究的腹型過敏性紫癜患兒300例,將其隨機(jī)分為6組(n=50):A組(小劑量甲潑尼龍聯(lián)合西咪替丁)、B組(小劑量甲潑尼龍聯(lián)合奧美拉唑)、C組(中劑量甲潑尼龍聯(lián)合西咪替丁)、D組(中劑量甲潑尼龍聯(lián)合奧美拉唑)、E組(大劑量甲潑尼龍聯(lián)合西咪替丁)、F組(大劑量甲潑尼龍聯(lián)合奧美拉唑)。各組數(shù)據(jù)采用多因素統(tǒng)計(jì)方法對比觀察各組療效及安全性。結(jié)果:(1)1d緩解率:F組的1天緩解率高于A、B、C組,差異有統(tǒng)計(jì)學(xué)意義(P"fα′),但尚不能認(rèn)為其余各組間的1天緩解率差異有統(tǒng)計(jì)學(xué)意義(Pα′)。(2)3d緩解率D、E、F組的3天緩解率均高于A組,差異有統(tǒng)計(jì)學(xué)意義(P"fα′)。F組的3天緩解率高于A、B、C組,差異有統(tǒng)計(jì)學(xué)意義(P"fα′)。但尚不能認(rèn)為其余各組間的3天緩解率差異有統(tǒng)計(jì)學(xué)意義(Pα′)。(3)癥狀反復(fù)率:E組、F組的消化道癥狀反復(fù)率均要低于A組,差異有統(tǒng)計(jì)學(xué)意義(P"fα′)。但尚不能認(rèn)為其余各組間的癥狀反復(fù)率差異有統(tǒng)計(jì)學(xué)意義(Pα′)。(4)激素副作用發(fā)生率:各組間差異均無統(tǒng)計(jì)學(xué)意義(P0.05)。(5)平均住院天數(shù):各組間差異均無統(tǒng)計(jì)學(xué)意義(P0.05)。結(jié)論:(1)大劑量甲潑尼龍聯(lián)合奧美拉唑相對于小劑量甲潑尼龍聯(lián)合西咪替丁或奧美拉唑以及中劑量甲潑尼龍聯(lián)合西咪替丁兒童腹型過敏性紫癜的療效更好,起效更快。(2)大劑量甲潑尼龍聯(lián)合奧美拉唑或西咪替丁相對于小劑量甲潑尼龍聯(lián)合西咪替丁治療兒童腹型過敏性紫癜的癥狀反復(fù)率更低。(3)小、中、大甲潑尼龍聯(lián)合奧美拉唑或西咪替丁治療兒童腹型過敏性紫癜的激素副作用發(fā)生率均較低。(4)小、中、大甲潑尼龍聯(lián)合奧美拉唑或西咪替丁治療兒童腹型過敏性紫癜的住院天數(shù)并無顯著差異。
[Abstract]:Aim: to compare the efficacy and safety of different doses of methylprednisolone combined with different acid suppressants in order to find the best treatment for children with abdominal Henoch-Schonlein purpura. Methods: a total of 300 children with abdominal Henoch-Schonlein purpura were randomly divided into 6 groups (n = 50): A): low dose methylprednisolone combined with cimetidine), B group (low dose methylprednisolone combined omeprazole). Group C (middle dose methylprednisolone combined with cimetidine), D group (middle dose methylprednisolone combined omeprazole), E group) and high dose methylprednisolone combined cimetidine), F group (high dose methylprednisolone combined omeprazole group). Multi-factor statistical method was used to observe the efficacy and safety of each group. Results: (1) one-day remission rate in group F was higher than that in group A, B and C (P "f 偽'). However, there was no significant difference in one-day response rate among the other groups (P 偽'). (2) 3 days remission rate D, E, F group 3-day response rate was higher than that of A group, and P 偽 'remission rate was significantly higher in E and F groups than in A group. The 3-day remission rate of P "f 偽'). F group was significantly higher than that of A, B and C groups (P" f 偽'). However, there was no significant difference in the 3-day remission rate among the other groups (P 偽'). (3): the recurrence rate of digestive tract symptoms in E group and F group was lower than that in A group, and the difference was statistically significant (P "f 偽'). However, there was no significant difference in symptom recurrence rate among the other groups (P 偽'). (4). There was no significant difference in the incidence of hormone side effects between groups (P0.05). (5). There was no significant difference among the groups (P0.05). Conclusion: (1) High-dose methylprednisolone combined with omeprazole is better than small-dose methylprednisolone combined with cimetidine or omeprazole or middle-dose methylprednisolone combined with cimetidine in children with abdominal Henoch-Schonlein purpura. (2) High-dose methylprednisolone combined with omeprazole or cimetidine had a lower symptom recurrence rate than low-dose methylprednisolone combined with cimetidine in the treatment of abdominal Henoch-Schonlein purpura in children. (3) small, middle, High methylprednisolone combined with omeprazole or cimetidine in the treatment of children with abdominal Henoch-Schonlein purpura has a lower incidence of hormone side effects. (4) small, middle, There was no significant difference in hospitalization days of large methylprednisolone combined with omeprazole or cimetidine in children with abdominal Henoch-Schonlein purpura.
【學(xué)位授予單位】：寧夏醫(yī)科大學(xué)
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2017
【分類號】：R725.5

【參考文獻(xiàn)】

相關(guān)期刊論文 前10條

1 林瑞峰;曾彩嬌;李紅;關(guān)則想;;不同劑量甲強(qiáng)龍治療兒童腹型過敏性紫癜的療效對比[J];齊齊哈爾醫(yī)學(xué)院學(xué)報(bào);2016年05期

2 潘笑悅;楊達(dá)勝;趙德安;畢凌云;周龍豪;;兒童紫癜性腎炎流行病學(xué)、發(fā)病機(jī)制及相關(guān)生物學(xué)指標(biāo)研究進(jìn)展[J];新鄉(xiāng)醫(yī)學(xué)院學(xué)報(bào);2015年04期

3 劉琳;劉志紅;;糖皮質(zhì)激素作用機(jī)制的研究進(jìn)展[J];腎臟病與透析腎移植雜志;2014年05期

4 吳天慧;李志輝;段翠蓉;尋勱;張翼;張良;丁云峰;銀燕;;3482例小兒過敏性紫癜流行病學(xué)分析[J];實(shí)用預(yù)防醫(yī)學(xué);2014年08期

5 王慧娟;頓耿;耿慶娜;;奧美拉唑治療兒童腹型過敏性紫癜的療效評價[J];中國中西醫(yī)結(jié)合皮膚性病學(xué)雜志;2014年01期

6 唐巧莉;;不同劑量甲強(qiáng)龍治療兒童腹型過敏性紫癜的療效對比[J];中外醫(yī)學(xué)研究;2013年28期

7 陳淑俠;張偉;;糖皮質(zhì)激素治療小兒過敏性紫癜消化道出血的臨床研究[J];中國醫(yī)療前沿;2013年13期

8 吳小川;唐雪梅;胡堅(jiān);張秋業(yè);黃建萍;李永柏;;兒童過敏性紫癜循證診治建議[J];中華兒科雜志;2013年07期

9 馬晶晶;朱宏;徐順福;施瑞華;;24例腹型過敏性紫癜的臨床、內(nèi)鏡及病理學(xué)特征分析[J];南京醫(yī)科大學(xué)學(xué)報(bào)(自然科學(xué)版);2013年01期

10 楊志國;朱保權(quán);;兒童過敏性紫癜的診治進(jìn)展[J];醫(yī)學(xué)綜述;2011年06期

相關(guān)會議論文 前1條

1 高琳;王競;俞晨;王剛;;重癥腹型過敏性紫癜臨床分析[A];中華醫(yī)學(xué)會第十八次全國皮膚性病學(xué)術(shù)年會論文匯編[C];2012年

相關(guān)碩士學(xué)位論文 前1條

1 魏雪旭;兒童過敏性紫癜腹型腸道粘膜損害的臨床研究[D];河北醫(yī)科大學(xué);2015年

，

本文編號：2453251