【摘要】：目的 :觀察青少年特發(fā)性脊柱側(cè)凸(adolescent idiopathic scoliosis,AIS)雙胞胎的共同發(fā)病率,比較同卵雙胞胎之間的發(fā)病特點(diǎn)。方法:2007年1月~2016年12月期間我院收錄同時(shí)患有AIS的雙胞胎患者21對,其中女19對(含三胞胎1例),男2對,記錄其初診年齡、女性月經(jīng)初潮年齡、BMI、Cobb角、胸椎后凸角、腰椎前凸角、Risser征等資料。通過短串聯(lián)重復(fù)序列檢測明確區(qū)分同卵雙胞胎與異卵雙胞胎,比較同卵雙胞胎和異卵雙胞胎的AIS共同發(fā)病率。選取同卵雙胞胎中兩人Cobb角差值≥10°的病例,將其中度數(shù)大者納入側(cè)凸較大組,度數(shù)小者納入側(cè)凸較小組,采用配對樣本t檢驗(yàn)比較兩組之間初潮年齡、BMI、Risser征臨床資料的差異。結(jié)果:21對雙胞胎平均初診年齡13.2±2.5歲,女性月經(jīng)初潮年齡12.2±1.4歲,初診時(shí)平均Cobb角29.2°±14.8°,胸椎后凸角16.8°±9.2°,腰椎前凸角45.5°±7.4°,BMI 17.0±1.6kg/m2,Risser征2.3±1.6。21對雙胞胎中同卵雙胞胎17對,異卵雙胞胎4對。同卵雙胞胎中16對(94.1%)共同患有AIS,11對(68.8%)彎型一致,4對(25.0%)Cobb角差值小于10°。異卵雙胞胎中3對(75.0%)共同患有AIS,1對(33.3%)彎型一致,1對(33.3%)Cobb角差值小于10°。同卵雙胞胎中Cobb角差值≥10°者12對,側(cè)凸較大組的月經(jīng)初潮年齡和BMI均小于側(cè)凸較小組(P0.05),Risser征兩組之間無統(tǒng)計(jì)學(xué)差異(P0.05)。結(jié)論 :同卵雙胞胎AIS患者共同發(fā)病率較高(94.1%)且彎型一致,但同卵雙胞胎兩者間畸形嚴(yán)重程度不一,雙胞胎中畸形較重者的月經(jīng)初潮年齡較小、BMI較低。
[Abstract]:Objective: to observe the common incidence of adolescent idiopathic scoliosis (adolescent idiopathic scoliosis,AIS) twins and compare the characteristics of identical twins. Methods: from January 2007 to December 2016, 21 pairs of twins with AIS were enrolled in our hospital, including 19 pairs of women (including 1 case of triplets) and 2 pairs of men. The age of first diagnosis, the age of menarche in women, the angle of BMI,Cobb, the kyphoid angle of thoracic vertebrae were recorded. Lumbar kyphosis angle, Risser sign and so on. The common incidence of AIS was compared between identical twins and fraternal twins by short tandem repeat (STR) detection. Two cases of identical twins whose Cobb angle difference was greater than 10 擄were selected, in which the larger degree was included in the greater group of scoliosis and the lesser degree was included in the group of scoliosis. The age of menarche between the two groups was compared by paired sample t test, BMI,. The difference of clinical data of Risser sign. Results: the mean age at first visit of 21 twins was 13.2 鹵2.5 years old, the menarche age of females was 12.2 鹵1.4 years old, the mean Cobb angle was 29.2 擄鹵14.8 擄, the thoracic kyphosis angle was 16.8 擄鹵9.2 擄, and the lumbar kyphosis angle was 45.5 擄鹵7.4 擄. BMI 17.0 鹵1.6kg / m2 risser's sign 2.3 鹵1.6.21 pairs of twins 17 pairs of identical twins and 4 pairs of fraternal twins. Among the identical twins, 16 pairs (94.1%) had the same AIS,11 pair (68.8%) and 4 pairs (25.0%) had a difference of Cobb angle less than 10 擄. Among fraternal twins, 3 pairs (75.0%) had the same AIS,1 pair (33.3%) and 1 pair (33.3%) had a difference of Cobb angle less than 10 擄. In 12 pairs of identical twins whose Cobb angle difference was more than 10 擄, menarche age and BMI in the larger scoliosis group were lower than those in the group with scoliosis (P0.05), Risser sign had no statistical difference between the two groups (P0.05). Conclusion: the incidence of AIS in identical twins is high (94.1%) and the concave type is the same. However, the degree of malformation between identical twins is different. The age of menarche and BMI are lower in the patients with severe malformation of identical twins.
【作者單位】： 南京大學(xué)醫(yī)學(xué)院附屬鼓樓醫(yī)院脊柱外科;
【基金】：江蘇省衛(wèi)生廳臨床醫(yī)學(xué)中心資助項(xiàng)目
【分類號】：R726.8
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本文編號：2415767