�？诘貐^(qū)小兒呼吸道病原體檢測(cè)結(jié)果分析
發(fā)布時(shí)間：2019-01-05 12:45
【摘要】：目的：對(duì)海南省中醫(yī)院、�？谑腥嗣襻t(yī)院住院及門(mén)診的小兒呼吸道感染患者檢測(cè)9種病原體抗體并進(jìn)行結(jié)果分析,探討�？诘貐^(qū)小兒呼吸道患者9種病原體的流行分布情況,不同年齡組、不同性別、不同季節(jié)病原體的檢出情況,為海口地區(qū)小兒呼吸道疾病預(yù)防策略制定、臨床診斷及治療提供病原學(xué)實(shí)驗(yàn)室依據(jù)。 方法：收集2013年1月至2013年12月在海南省中醫(yī)院、�？谑腥嗣襻t(yī)院住院及門(mén)診小兒呼吸道感染患者1144例,按照小兒的年齡分期標(biāo)準(zhǔn),分為4個(gè)年齡組。應(yīng)用間接免疫熒光法同時(shí)對(duì)9種病原體行血清IgM抗體聯(lián)合檢測(cè)及分析研究,這9種病原體分別為嗜肺軍團(tuán)菌(LP),肺炎支原體(MP),Q熱立克次體(COX),肺炎衣原體(CPm),腺病毒(AdV),呼吸道合胞病毒(RSV),甲型流感病毒(INFA)和乙型流感病毒(INFB),副流感病毒(PIVs)。 結(jié)果：1.1144例患者血清樣本中,檢出IgM抗體陽(yáng)性536例,陽(yáng)性率為46.85%。單項(xiàng)感染339例,陽(yáng)性率為29.63%。 2.單項(xiàng)感染排前三位的分別是MP,陽(yáng)性率為22.5%(258/1144)、INFB,陽(yáng)性率為4.11%(47/1144)、LP陽(yáng)性率為2.27%(26/1144)�；旌细腥�197例,以MP+INFB感染為主,占10.23%(117/1144)：其次為L(zhǎng)P+MP混合感染,陽(yáng)性率為2.62%(30/1144)；第三位是LP+MP+INFB混合感染,陽(yáng)性率為1.92%(22/1144)；其陽(yáng)性率和構(gòu)成比均不同(P0.05)。 3.4個(gè)年齡組陽(yáng)性率隨年齡增加而增加,學(xué)齡前期組感染陽(yáng)性率高,為73.06%(198/270),其次為幼兒組,陽(yáng)性率為63.00%(126/200),第三位為嬰兒后期組,陽(yáng)性率為48.93%(183/374),各組陽(yáng)性率及構(gòu)成比均不相同(P0.05)。 4.1144個(gè)病例中,檢出536例病原體抗體呈陽(yáng)性反應(yīng),其中男性326例,陽(yáng)性率為41.85%,構(gòu)成比為0.61；女性210例,陽(yáng)性率為57.53%,男性和女性感染的陽(yáng)性率和構(gòu)成比均不同(P0.05)。在男性混合感染中,陽(yáng)性率排在前三位的分別為MP+INFB(陽(yáng)性率為7.96%)、LP+MP(陽(yáng)性率為2.70%)和LP+MP+INFB(1.41%)。在女性混合感染中,陽(yáng)性率排在前三位的分別為MP+INFB(陽(yáng)性率為15.07%)、LP+MP+INFB(陽(yáng)性率為3.01%)和LP+MP(陽(yáng)性率為2.47%),三種組合的病原體間感染陽(yáng)性率及構(gòu)成比均各不同(P0.05),同種病原體在不同性別中感染陽(yáng)性率各不同(P0.05)。 5.四個(gè)季節(jié)中,夏季感染陽(yáng)性率高達(dá)51.84%,構(gòu)成比為0.32；秋季為50.16%,春季為48.34,冬季為31.16%。經(jīng)卡方檢驗(yàn),與冬季相比,其他三個(gè)季節(jié)陽(yáng)性率和構(gòu)成比均顯著上升(P0.05),而夏季與秋季間陽(yáng)性率與構(gòu)成比均無(wú)顯著差異(P0.05)。在春季,9種病原體感染陽(yáng)性率前三位分別為MP、MP+INFB、MP+LP。在夏季,9種病原體感染陽(yáng)性率前三位分別為MP、MP+INFB、INFB。在秋季,9種病原體感染陽(yáng)性率前三位分別為MP、MP+INFB、INFB。在冬季,9種病原體感染陽(yáng)性率前三位分別為MP、LP、INFB。選擇感染陽(yáng)性率較高的4種感染類(lèi)型,分別為MP、LP、INFB、MP+INFB,分析其在各季節(jié)中陽(yáng)性率差異。MP感染的陽(yáng)性率在夏季顯著上升(P0.05),LP感染的陽(yáng)性率在冬季顯著上升(P0.05),INFB感染的陽(yáng)性率在秋季顯著上升(P0.05),MP+INFB感染的陽(yáng)性率在秋季顯著上升(P0.05)。 結(jié)論：1.�？诘貐^(qū)9種小兒呼吸道病原體,單項(xiàng)感染以肺炎支原體感染為常見(jiàn),混合感染以肺炎支原體合并乙型流感病毒感染為主,單項(xiàng)感染多于混合感染。 2.9種小兒呼吸道病原體感染在不同年齡段的陽(yáng)性率有顯著不同,學(xué)齡前期組最高,嬰兒前期組最低。 3.男性和女性感染的陽(yáng)性率和構(gòu)成比均不同。 4.9種小兒呼吸道病原體流行還與季節(jié)有關(guān)。 5.該研究為�？诘貐^(qū)預(yù)防策略制定、臨床診斷、合理用藥提供病原學(xué)實(shí)驗(yàn)室依據(jù)。
[Abstract]:Objective: To study the prevalence and distribution of 9 pathogens in children with respiratory tract infection in the hospital of Hainan, the hospital of the people's hospital in Haikou, and in the clinic, and to study the distribution of 9 pathogens in the children's respiratory tract of Haikou. The detection of pathogens in different seasons provides a basis for the development, clinical diagnosis and treatment of children's respiratory diseases in Haikou. Methods: A total of 1144 children with respiratory tract infection were collected from January 2013 to December 2013 in the middle hospital of Hainan Province, the hospital of the people's hospital of Haikou City and the children with respiratory tract infection in the clinic. The results of the combined detection and analysis of the serum IgM antibodies in 9 pathogens were carried out by indirect immunofluorescence. The nine pathogens were pneumophila (LP), Mycoplasma hyopneumoniae (MP), Q-thermogram subbody (COX), Chlamydia pneumoniae (CPm), and adenovirus (AdV).), Respiratory Syncytial Virus (RSV), Influenza A (INFA) and Influenza B (INFB), Parainfluenza Virus (PIVs) Results: In the serum samples of 1,1144 patients, the positive rate of IgM antibody was found in 536 cases, and the positive rate was 46. The positive rate was 29 in 339 cases of single infection. The positive rate was 22. 5% (258/ 1144), the positive rate of INFB was 4.11% (47/ 1144), and the positive rate of LP was 2.27% (26/ 120). The positive rate of the mixed infection was 2.62% (30/ 1144), the positive rate was 1.92% (22/ 1144), the positive rate and the composition ratio were different (P (0.05). The positive rate of the 4 age groups increased with the age, the positive rate of the infection in the pre-school group was high, it was 73.06% (198/ 270), the second was the infant group, the positive rate was 63. 00% (126/ 200), the third was the late group of the baby, the positive rate was 48.93% (183/ 374), the positive rate and the composition ratio of each group were not the same. (P0.05). Among the 1144 cases, 536 cases of pathogen antibody were positive, of which 326 were male, the positive rate was 41. 85%, the composition ratio was 0.61, the positive rate was 57. 53%, and the positive rate and the composition ratio of male and female infection were all. In male mixed infection, the positive rate was MP + INFB (positive rate was 7.96%), and LP + MP (positive rate was 2.70%) and LP + MP + IN. The positive rate of positive rate in female mixed infection was MP + INFB (positive rate was 15.07%), LP + MP + INFB (positive rate was 3.01%) and LP + MP (positive rate was 2.47%), and the positive rate and composition ratio of the three combinations were all. The positive rate of the same pathogen in different sex was different (P0.05). In the four seasons, the positive rate of infection in summer was 51. 84%, the composition ratio was 0.32, the fall was 50. 16%, and the spring was 48. 3. 4, 31. 16% in winter. The positive rate and composition ratio of the other three seasons were significantly higher than that in winter (P0.05), while the positive rate and composition ratio in summer and autumn were none. There were significant differences (P0.05). In spring, the positive rate of 9 pathogens was MP, MP, respectively. + INFB, MP + LP. In summer, the positive rate of 9 pathogens was MP, M, respectively. The positive rate of P + INFB, INFB. In autumn, the positive rate of 9 pathogens was MP, M, respectively. The positive rate of P + INFB, INFB. In winter, the positive rate of nine pathogens was the first three. Four types of infection were selected for MP, LP, INFB, MP, LP, INFB, MP + INFB. The positive rate of the infection was significantly higher in the summer (P0.05). The positive rate of the infection was significantly higher in the winter (P0.05). The positive rate of INFB infection increased significantly in the autumn (P0.05). The positive rate of the infection of MP + INFB was in the fall. a significant increase (Conclusion: 1. The infection of 9 children's respiratory pathogens in the Haikou area is common with the mycoplasma pneumoniae infection, and the mixed infection is the combination of the mycoplasma pneumoniae and the influenza B virus infection. 2. The positive rate of respiratory pathogens in 9 children was significantly different in different age groups. The highest in the pre-school group and the lowest in the early-stage group. The positive rate and composition ratio of sex and female infection are different. 9. The prevalence of respiratory pathogens in 9 children is also related to the season.
【學(xué)位授予單位】：中南大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2014
【分類(lèi)號(hào)】：R725.6
本文編號(hào)：2401799
[Abstract]:Objective: To study the prevalence and distribution of 9 pathogens in children with respiratory tract infection in the hospital of Hainan, the hospital of the people's hospital in Haikou, and in the clinic, and to study the distribution of 9 pathogens in the children's respiratory tract of Haikou. The detection of pathogens in different seasons provides a basis for the development, clinical diagnosis and treatment of children's respiratory diseases in Haikou. Methods: A total of 1144 children with respiratory tract infection were collected from January 2013 to December 2013 in the middle hospital of Hainan Province, the hospital of the people's hospital of Haikou City and the children with respiratory tract infection in the clinic. The results of the combined detection and analysis of the serum IgM antibodies in 9 pathogens were carried out by indirect immunofluorescence. The nine pathogens were pneumophila (LP), Mycoplasma hyopneumoniae (MP), Q-thermogram subbody (COX), Chlamydia pneumoniae (CPm), and adenovirus (AdV).), Respiratory Syncytial Virus (RSV), Influenza A (INFA) and Influenza B (INFB), Parainfluenza Virus (PIVs) Results: In the serum samples of 1,1144 patients, the positive rate of IgM antibody was found in 536 cases, and the positive rate was 46. The positive rate was 29 in 339 cases of single infection. The positive rate was 22. 5% (258/ 1144), the positive rate of INFB was 4.11% (47/ 1144), and the positive rate of LP was 2.27% (26/ 120). The positive rate of the mixed infection was 2.62% (30/ 1144), the positive rate was 1.92% (22/ 1144), the positive rate and the composition ratio were different (P (0.05). The positive rate of the 4 age groups increased with the age, the positive rate of the infection in the pre-school group was high, it was 73.06% (198/ 270), the second was the infant group, the positive rate was 63. 00% (126/ 200), the third was the late group of the baby, the positive rate was 48.93% (183/ 374), the positive rate and the composition ratio of each group were not the same. (P0.05). Among the 1144 cases, 536 cases of pathogen antibody were positive, of which 326 were male, the positive rate was 41. 85%, the composition ratio was 0.61, the positive rate was 57. 53%, and the positive rate and the composition ratio of male and female infection were all. In male mixed infection, the positive rate was MP + INFB (positive rate was 7.96%), and LP + MP (positive rate was 2.70%) and LP + MP + IN. The positive rate of positive rate in female mixed infection was MP + INFB (positive rate was 15.07%), LP + MP + INFB (positive rate was 3.01%) and LP + MP (positive rate was 2.47%), and the positive rate and composition ratio of the three combinations were all. The positive rate of the same pathogen in different sex was different (P0.05). In the four seasons, the positive rate of infection in summer was 51. 84%, the composition ratio was 0.32, the fall was 50. 16%, and the spring was 48. 3. 4, 31. 16% in winter. The positive rate and composition ratio of the other three seasons were significantly higher than that in winter (P0.05), while the positive rate and composition ratio in summer and autumn were none. There were significant differences (P0.05). In spring, the positive rate of 9 pathogens was MP, MP, respectively. + INFB, MP + LP. In summer, the positive rate of 9 pathogens was MP, M, respectively. The positive rate of P + INFB, INFB. In autumn, the positive rate of 9 pathogens was MP, M, respectively. The positive rate of P + INFB, INFB. In winter, the positive rate of nine pathogens was the first three. Four types of infection were selected for MP, LP, INFB, MP, LP, INFB, MP + INFB. The positive rate of the infection was significantly higher in the summer (P0.05). The positive rate of the infection was significantly higher in the winter (P0.05). The positive rate of INFB infection increased significantly in the autumn (P0.05). The positive rate of the infection of MP + INFB was in the fall. a significant increase (Conclusion: 1. The infection of 9 children's respiratory pathogens in the Haikou area is common with the mycoplasma pneumoniae infection, and the mixed infection is the combination of the mycoplasma pneumoniae and the influenza B virus infection. 2. The positive rate of respiratory pathogens in 9 children was significantly different in different age groups. The highest in the pre-school group and the lowest in the early-stage group. The positive rate and composition ratio of sex and female infection are different. 9. The prevalence of respiratory pathogens in 9 children is also related to the season.
【學(xué)位授予單位】：中南大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2014
【分類(lèi)號(hào)】：R725.6
【共引文獻(xiàn)】
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