【摘要】：目的研究枸櫞酸咖啡因?qū)υ绠a(chǎn)兒生后早期腦電活動的影響。方法選取2016年1月—2016年9月出生后即收治新生兒重癥監(jiān)護(hù)室,產(chǎn)時無窒息搶救史、出生胎齡28~34周的早產(chǎn)兒為研究對象,以住院期間未使用任何興奮呼吸中樞藥物的早產(chǎn)兒為正常對照組,以相同校正胎齡、住院期間規(guī)范使用過枸櫞酸咖啡因治療早產(chǎn)兒為咖啡因組。在咖啡因組早產(chǎn)兒停用枸櫞酸咖啡因后,分別在校正胎齡33、34、35周行振幅整合腦電圖(a EEG)檢測,每次連續(xù)監(jiān)測4 h,使用Burdjalov評分表對a EEG圖像進(jìn)行評價并分別測算暴發(fā)間期,分析枸櫞酸咖啡因?qū)τ谠绠a(chǎn)兒生后早期腦電活動的影響。結(jié)果共納入49例早產(chǎn)兒,咖啡因組21例、對照組28例,男女比例1.45:1。在同一校正胎齡時,咖啡因組與對照組a EEG的Burdjalov評分總分及各單項評分的差異均無統(tǒng)計學(xué)意義(P0.05);咖啡因組的暴發(fā)間期短于對照組,差異有統(tǒng)計學(xué)意義(P0.05)。所有入選早產(chǎn)兒a EEG監(jiān)測時均未見明顯驚厥樣電活動。結(jié)論枸櫞酸咖啡因的使用對早產(chǎn)兒早期腦電活動有影響,可能加速了早產(chǎn)兒腦功能發(fā)育成熟。
[Abstract]:Objective to study the effect of caffeine citrate on the early postnatal EEG activity of preterm infants. Methods premature infants who were admitted to neonatal intensive care unit after birth from January 2016 to September 2016, who had no history of asphyxia at birth and were born at the age of 2834 weeks, were selected as the subjects of the study. Premature infants who did not use any exciting respiratory central drugs during hospitalization were taken as normal control group, and those preterm infants who were treated with citrate caffeine during hospitalization were treated with caffeine as caffeine group with the same corrected gestational age. After withdrawal of citrate caffeine from caffeine group, amplitude-integrated electroencephalogram (a EEG) was measured at the corrected gestational age of 33,34 weeks for 35 weeks, followed by continuous monitoring for 4 hours. A EEG image was evaluated by Burdjalov scoring table and the interoutbreak period was calculated. To analyze the effect of caffeine citrate on EEG activity in preterm infants. Results A total of 49 premature infants were included, 21 in caffeine group and 28 in control group. The ratio of male to female was 1.45: 1. At the same corrected gestational age, there was no significant difference in the total score of a EEG and each item score between caffeine group and control group (P0.05); the interval of outbreak in caffeine group was shorter than that in control group, the difference was statistically significant (P0.05). No significant convulsive activity was observed in all preterm infants during a EEG monitoring. Conclusion the use of caffeine citrate has an effect on the early EEG activity of preterm infants and may accelerate the maturation of brain function in preterm infants.
【作者單位】： 上海交通大學(xué)醫(yī)學(xué)院附屬上海兒童醫(yī)學(xué)中心新生兒重癥監(jiān)護(hù)室;
【分類號】：R722.6

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