【摘要】：目的探討幽門螺桿菌(Hp)感染對免疫性血小板減少癥(ITP)患兒免疫水平的影響。方法選擇2014年6月-2016年6月醫(yī)院兒科收治的免疫性血小板減少癥的患兒72例,作為ITP組,其中ITP組又分為Hp陽性34例,陰性38例;同時選取同一時期在醫(yī)院行健康檢查的兒童44例,作為對照組;比較對照組和ITP患兒組的Hp感染率;比較ITP患兒組與對照組及ITP組中Hp陽性亞組與Hp陰性亞組淋巴細胞亞群表達情況;比較ITP組與對照組及ITP組中Hp陽性亞組與Hp陰性亞組血清中免疫因子的表達情況。結(jié)果 ITP患兒感染Hp的感染率顯著高于對照組兒童(P0.05);ITP患兒的免疫細胞表達水平較對照組兒童顯著改變,具有顯著性差異(P0.05),但Hp陽性患兒的免疫細胞表達水平較Hp陰性患兒未發(fā)生顯著性變化;ITP患兒的免疫因子表達較對照組兒童發(fā)生顯著性變化,Hp陽性患兒的免疫因子表達水平較Hp陰性患兒發(fā)生顯著性變化。結(jié)論ITP患兒存在Hp感染高發(fā)的現(xiàn)象且存在免疫細胞表達水平的明顯改變,其中Hp陽性患兒免疫因子表達水平也發(fā)生顯著變化,值得臨床治療重視。
[Abstract]:Objective to investigate the effect of Helicobacter pylori (Hp) infection on immune level of (ITP) children with immune thrombocytopenia. Methods 72 cases of immune thrombocytopenia in pediatrics from June 2014 to June 2016 were selected as ITP group. The ITP group was divided into 34 cases of Hp positive and 38 cases of negative. At the same time, 44 children who underwent health examination in hospital in the same period were selected as the control group, the infection rate of Hp was compared between the control group and the ITP group. To compare the expression of lymphocyte subsets of Hp positive subgroup and Hp negative subgroup in children with ITP, control group and ITP group, and to compare the expression of immune factor in serum of Hp positive subgroup and Hp negative subgroup in ITP group and control group and ITP group. Results the infection rate of Hp in children with ITP was significantly higher than that in the control group (P0.05). The expression level of immune cells in ITP children was significantly different from that in the control group (P0.05), but the expression level of immune cells in Hp positive children was not significantly different from that in Hp negative children. The expression of immune factors in children with ITP was significantly different from that in the control group, and the expression level of immune factors in Hp positive children was significantly higher than that in children with Hp negative. Conclusion there is a high incidence of Hp infection and obvious changes in immunocyte expression in children with ITP, and the expression of immune factors in Hp positive children is also significantly changed, which deserves the attention of clinical treatment.
【作者單位】： 寧波市婦女兒童醫(yī)院消化科;寧波市婦女兒童醫(yī)院風濕免疫科;寧波市婦女兒童醫(yī)院檢驗科;
【分類號】：R725.5

【相似文獻】

相關(guān)期刊論文 前10條

1 ;小兒免疫及原發(fā)性免疫缺陷病[J];中國醫(yī)學文摘(兒科學);2002年03期

2 梁士強;宋振鵬;薛冰;;2006年費縣0～15歲兒童結(jié)核免疫水平調(diào)查[J];預(yù)防醫(yī)學論壇;2007年07期

3 崔廣梅,宋冠縣,郭成偉,陳建民,英有臺;費縣少年兒童結(jié)核免疫水平調(diào)查[J];臨沂醫(yī)專學報;1999年01期

4 邱世聰;陳貴孚;章建生;米從明;陳京;程能能;;農(nóng)村婦兒肺通氣功能免疫水平的配對分析[J];皖南醫(yī)學院學報;1990年02期

5 劉慶山;;西湖區(qū)兒童預(yù)防接種后免疫水平的監(jiān)測和分析[J];中國現(xiàn)代醫(yī)生;2008年34期

6 何吉蘭,王敦志,羅家聰,秦明輝,孫莉,劉兆偉;4歲兒童對四川Ⅰ型脊髓灰質(zhì)炎野病毒的免疫水平觀察[J];預(yù)防醫(yī)學情報雜志;2001年01期

7 王繼杰,顏天強,李喬生,文中蘭,夏國良,劉崇柏;兒童乙型肝炎疫苗加強免疫效果研究[J];實用預(yù)防醫(yī)學;2002年03期

8 王紅霞，汪洋杰，樊忠亮，薄福寶，劉夢來，張風賢，徐玉霞，李粉霞;呼和浩特市農(nóng)區(qū)小學生麻疹免疫水平及再免疫后效果監(jiān)測[J];疾病監(jiān)測;1995年11期

9 郝寶榮;;暴露煉焦污染對兒童的免疫水平及肺功能影響分析[J];海峽預(yù)防醫(yī)學雜志;2008年04期

10 劉建林;1991年南寧市兒童白喉免疫水平調(diào)查[J];廣西預(yù)防醫(yī)學;1995年04期

相關(guān)碩士學位論文 前1條

1 沈靈智;5～16歲兒童乙肝疫苗加強免疫效果研究[D];寧波大學;2012年

，

本文編號：2308973