兒童益肺膏治療小兒哮喘緩解期脾肺氣虛證的臨床研究
發(fā)布時間：2018-10-31 18:19
【摘要】：本研究依照隨機、對照的原則,在武漢市中醫(yī)醫(yī)院,對兒童益肺膏治療小兒哮喘緩解期肺脾氣虛證的有效性、安全性進行了系統(tǒng)觀察,本研究目前仍在進行中,現(xiàn)將2015年12月至2017年2月間療程滿6周后并觀察1年的病例進行統(tǒng)計分析,共80例哮喘緩解期脾肺氣虛型患兒,治療組40例、對照組40例。目的:采取隨機、對照的臨床研究方式,觀察對比兒童益肺膏和西醫(yī)對照藥物兩種不同治療方案下的療效,客觀評價兒童益肺膏用于哮喘緩解期,在提高哮喘控制水平、減輕中醫(yī)癥候積分等方面的有效性和安全性。方法:采取隨機、對照的研究方法,對80例哮喘緩解期脾肺氣虛型患兒進行臨床研究,治療組采用兒童益肺膏口服治療;對照組采用西醫(yī)對照藥物,療程均為6周。療程結束后對兩組患兒哮喘控制水平、C-ACT評分、中醫(yī)證候積分等進行評價,兩組治療前后相關實驗室指標和治療結束半年后及一年后有效率進行比較。采納統(tǒng)計軟件SPSS 17.0對數據結果進行分析,包括x~2檢驗、t檢驗、Kruskal Wallis H檢驗。結果:(1)治療后治療組、對照組總有效率分別為82.5%、62.5%,兩組比較有統(tǒng)計學意義(P0.05);(2)治療后兩組C-ACT評分平均值均有上升,兩組C-ACT評分治療前后比較有統(tǒng)計學意義(P0.05),治療組與對照組治療后比較有統(tǒng)計學意義(P0.05);(3)兩組治療后中醫(yī)癥候積分平均值均有下降,治療組治療后中醫(yī)癥候積分評分與治療前相比有統(tǒng)計學意義(P0.05),與對照組治療后中醫(yī)癥候積分比較有統(tǒng)計學意義(P0.05);(4)兩組對FEV1、PEF均有改善作用,每組治療前后比較均有統(tǒng)計學意義(P0.05),且兩組治療后比較均有統(tǒng)計學意義(P0.05);(5)兩組治療后IgE水平均有下降,IgG、IgM水平均有上升,治療組治療前后比較有統(tǒng)計學意義(P0.05);(6)兩組治療后血嗜酸性粒細胞計數均有明顯降低,與本組治療前比較差異有統(tǒng)計學意義(P0.O5),治療組與對照組治療后比較差異有統(tǒng)計學意義(P0.O5);(7)兩組在治療半年后、一年后有效率均有上升,但是對照組治療有效率與同期對照組比較有統(tǒng)計學意義(P0.O5)。結論:小兒哮喘緩解期脾肺氣虛證應用兒童益肺膏,減輕哮喘發(fā)作程度,減低哮喘C-ACT評分,提高哮喘控制水平,調節(jié)患兒免疫功能,改善其肺功能,說明兒童益肺膏可以達到防治哮喘緩解期脾肺氣虛證的目的,具有極高的臨床應用價值,值得推廣。
[Abstract]:According to the principle of randomness and control, this study made a systematic observation on the efficacy and safety of children's Yifei ointment in treating asthmatic patients with deficiency of lung and spleen qi in the hospital of traditional Chinese medicine of Wuhan City, and this study is still in progress. From December 2015 to February 2017, 80 children with spleen and lung qi deficiency in remission of asthma were statistically analyzed, 40 in treatment group and 40 in control group after 6 weeks of treatment from December 2015 to February 2017. Objective: to observe and compare the therapeutic effects of children's Yifei ointment and western medicine in different therapeutic schemes, and to evaluate objectively the therapeutic effect of children's Yifei ointment in asthma remission period, and to improve the asthma control level. Reduce the effectiveness and safety of TCM symptom score. Methods: a randomized, controlled study was carried out in 80 children with asthmatic remission of spleen and lung qi deficiency. The treatment group was treated with Yifei ointment orally, while the control group was treated with western medicine for 6 weeks. The asthma control level, C-ACT score, TCM syndrome score and so on were evaluated after the course of treatment. The laboratory indexes before and after treatment and the effective rate six months after treatment and one year after treatment were compared between the two groups. The statistical software SPSS 17.0 was used to analyze the data, including x2 test and t-test, Kruskal Wallis H test. Results: (1) in the treatment group, the total effective rate of the control group was 82.5 and 62.5, respectively. There was statistical significance between the two groups (P0.05). (2) after treatment, the average C-ACT scores of the two groups increased, the C-ACT scores of the two groups were statistically significant before and after treatment (P0.05), the treatment group and the control group after treatment had statistical significance (P0.05); (3) the mean scores of TCM symptom scores in the two groups were decreased after treatment, and the scores of TCM symptom scores in the treatment group were significantly higher than those before treatment (P0.05). Compared with the control group after treatment, TCM symptom score had statistical significance (P0.05). (4) FEV1,PEF was improved in both groups, there was significant difference before and after treatment (P0.05), and there was significant difference after treatment (P0.05). (5) the level of IgE decreased and the level of IgG,IgM increased after treatment in both groups. There was statistical significance before and after treatment in treatment group (P0.05). (6) after treatment, the eosinophil count in the two groups was significantly lower than that before treatment (P0.O5), and there was a significant difference (P0.O5) between the treatment group and the control group after treatment. (7) after six months of treatment, the effective rate of the two groups increased after one year, but the effective rate of the control group was significantly higher than that of the control group (P0.O5). Conclusion: children with asthmatic patients with deficiency of spleen and lung qi were treated with Yifei ointment to reduce the severity of asthma attack, reduce the C-ACT score of asthma, improve the level of asthma control, regulate the immune function of children, and improve their lung function. It is suggested that the children's Yifei ointment can prevent and cure the deficiency of spleen and lung qi in the asthmatic remission period, which has high clinical application value and is worth popularizing.
【學位授予單位】：湖北中醫(yī)藥大學
【學位級別】：碩士
【學位授予年份】：2017
【分類號】：R272
[Abstract]:According to the principle of randomness and control, this study made a systematic observation on the efficacy and safety of children's Yifei ointment in treating asthmatic patients with deficiency of lung and spleen qi in the hospital of traditional Chinese medicine of Wuhan City, and this study is still in progress. From December 2015 to February 2017, 80 children with spleen and lung qi deficiency in remission of asthma were statistically analyzed, 40 in treatment group and 40 in control group after 6 weeks of treatment from December 2015 to February 2017. Objective: to observe and compare the therapeutic effects of children's Yifei ointment and western medicine in different therapeutic schemes, and to evaluate objectively the therapeutic effect of children's Yifei ointment in asthma remission period, and to improve the asthma control level. Reduce the effectiveness and safety of TCM symptom score. Methods: a randomized, controlled study was carried out in 80 children with asthmatic remission of spleen and lung qi deficiency. The treatment group was treated with Yifei ointment orally, while the control group was treated with western medicine for 6 weeks. The asthma control level, C-ACT score, TCM syndrome score and so on were evaluated after the course of treatment. The laboratory indexes before and after treatment and the effective rate six months after treatment and one year after treatment were compared between the two groups. The statistical software SPSS 17.0 was used to analyze the data, including x2 test and t-test, Kruskal Wallis H test. Results: (1) in the treatment group, the total effective rate of the control group was 82.5 and 62.5, respectively. There was statistical significance between the two groups (P0.05). (2) after treatment, the average C-ACT scores of the two groups increased, the C-ACT scores of the two groups were statistically significant before and after treatment (P0.05), the treatment group and the control group after treatment had statistical significance (P0.05); (3) the mean scores of TCM symptom scores in the two groups were decreased after treatment, and the scores of TCM symptom scores in the treatment group were significantly higher than those before treatment (P0.05). Compared with the control group after treatment, TCM symptom score had statistical significance (P0.05). (4) FEV1,PEF was improved in both groups, there was significant difference before and after treatment (P0.05), and there was significant difference after treatment (P0.05). (5) the level of IgE decreased and the level of IgG,IgM increased after treatment in both groups. There was statistical significance before and after treatment in treatment group (P0.05). (6) after treatment, the eosinophil count in the two groups was significantly lower than that before treatment (P0.O5), and there was a significant difference (P0.O5) between the treatment group and the control group after treatment. (7) after six months of treatment, the effective rate of the two groups increased after one year, but the effective rate of the control group was significantly higher than that of the control group (P0.O5). Conclusion: children with asthmatic patients with deficiency of spleen and lung qi were treated with Yifei ointment to reduce the severity of asthma attack, reduce the C-ACT score of asthma, improve the level of asthma control, regulate the immune function of children, and improve their lung function. It is suggested that the children's Yifei ointment can prevent and cure the deficiency of spleen and lung qi in the asthmatic remission period, which has high clinical application value and is worth popularizing.
【學位授予單位】：湖北中醫(yī)藥大學
【學位級別】：碩士
【學位授予年份】：2017
【分類號】：R272
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