藥物基因組學(xué)在甲氨蝶呤治療兒童急性淋巴細(xì)胞白血病中的應(yīng)用進(jìn)展
發(fā)布時間:2018-09-12 20:37
【摘要】:甲氨蝶呤(MTX)廣泛應(yīng)用于兒童急性淋巴細(xì)胞白血病(ALL)的鞏固治療和維持治療,具有良好的治療效果,但會引起較嚴(yán)重的不良反應(yīng)。藥物基因組學(xué)研究顯示,SLCO1B1基因、ABC轉(zhuǎn)運(yùn)蛋白、葉酰聚谷氨酸合成酶(FPGS)、谷氨酰水解酶(GGH)、亞甲基四氫葉酸還原酶(MTHFR)、胸苷酸合成酶(TYMS或TS)基因多態(tài)性與MTX治療兒童ALL的療效和不良反應(yīng)具有相關(guān)性。在應(yīng)用MTX治療ALL時,應(yīng)關(guān)注影響MTX代謝及轉(zhuǎn)運(yùn)的相關(guān)基因多態(tài)性。
[Abstract]:Methotrexate (MTX) is widely used in the consolidation and maintenance of acute lymphoblastic leukemia (ALL) in children. Pharmacogenomics studies showed that the SLCO1B1 gene was a transporter of ABC. The polymorphism of leaf polyglutamic acid synthase (FPGS), glutamyl hydrolase (GGH), methylene tetrahydrofolate reductase (MTHFR), thymidine synthase (TYMS or TS) gene was correlated with the therapeutic effect and adverse reaction of MTX in the treatment of ALL in children. In the treatment of ALL with MTX, attention should be paid to the gene polymorphisms that affect the metabolism and transport of MTX.
【作者單位】: 四川省醫(yī)學(xué)科學(xué)院·四川省人民醫(yī)院;電子科技大學(xué)醫(yī)學(xué)院;
【基金】:四川省科技基礎(chǔ)條件平臺基金資助項(xiàng)目(14010159) 2015年四川省人民醫(yī)院青年科研基金(2015QN08)
【分類號】:R733.71
[Abstract]:Methotrexate (MTX) is widely used in the consolidation and maintenance of acute lymphoblastic leukemia (ALL) in children. Pharmacogenomics studies showed that the SLCO1B1 gene was a transporter of ABC. The polymorphism of leaf polyglutamic acid synthase (FPGS), glutamyl hydrolase (GGH), methylene tetrahydrofolate reductase (MTHFR), thymidine synthase (TYMS or TS) gene was correlated with the therapeutic effect and adverse reaction of MTX in the treatment of ALL in children. In the treatment of ALL with MTX, attention should be paid to the gene polymorphisms that affect the metabolism and transport of MTX.
【作者單位】: 四川省醫(yī)學(xué)科學(xué)院·四川省人民醫(yī)院;電子科技大學(xué)醫(yī)學(xué)院;
【基金】:四川省科技基礎(chǔ)條件平臺基金資助項(xiàng)目(14010159) 2015年四川省人民醫(yī)院青年科研基金(2015QN08)
【分類號】:R733.71
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1 盧燕;甲氨蝶呤在兒童急性淋巴細(xì)胞白血病中的應(yīng)用進(jìn)展[J];繼續(xù)醫(yī)學(xué)教育;2001年02期
2 朱光華;周,
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