【摘要】：目的：探討血清維生素D與毛細(xì)支氣管炎的臨床聯(lián)系。方法按照毛細(xì)支氣管炎診斷標(biāo)準(zhǔn),從來新疆醫(yī)科大學(xué)第一附屬醫(yī)院就診的患兒中選取190例缺乏維生素D的毛細(xì)支氣管炎患兒,隨機(jī)分為實驗組和對照組,其中實驗組91例(男61例,女30例)與對照組99例(男70例,女29例),所有實驗組患兒均在入院后進(jìn)行抗感染治療,并開始補(bǔ)充維生素D1個月。所有對照組均在入院后進(jìn)行抗感染治療,治療方法同實驗組。記錄兩組患兒臨床癥狀緩解時間及住院天數(shù),并于治療前檢測所有患兒血清25-OHD3、IgA、IgG、CD4+、CD8+、CD4+/CD8+水平,對以上兩組研究對象進(jìn)行追蹤隨訪3個月,滿3個月后,復(fù)查相關(guān)指標(biāo)并統(tǒng)計兩組的復(fù)發(fā)次數(shù)。結(jié)果治療前實驗組與對照組患兒血清25-羥維生素D3(25-OHD3)、ALP、IgA、IgG、 CD4+、CD8+、CD4+/CD8+水平相比較,差異均無統(tǒng)計學(xué)意義(P0.05)。治療后,實驗組血清IgA、IgG水平均較治療前高,差異有統(tǒng)計學(xué)意義(P0.05),而血清ALP跟治療前相比,差異無統(tǒng)計學(xué)意義(P0.05)；治療后實驗組血清ALP、IgA、IgG, CD4+、CD8+、CD4+/CD8+水平與對照組相比,實驗組IgA、IgG、CD4+、CD4+/CD8+水平均較對照組增高,差異有統(tǒng)計學(xué)意義(P0.05),而血清ALP、CD8+差異無統(tǒng)計學(xué)意義(P0.05)。實驗組住院天數(shù)及癥狀緩解天數(shù)均較對照組短,差異有統(tǒng)計學(xué)意義(P0.05),且出院后復(fù)發(fā)次數(shù)較對照組少,差異有統(tǒng)計學(xué)意義(P0.05)。結(jié)論維生素D可以通過對機(jī)體免疫功能的調(diào)節(jié)來影響毛細(xì)支氣管炎的預(yù)防及治療,對毛細(xì)支氣管炎的預(yù)防及治療發(fā)揮著積極作用。
[Abstract]:Objective: to investigate the relationship between serum vitamin D and bronchiolitis. Methods according to the diagnostic criteria of bronchiolitis, 190 children with vitamin D deficiency bronchiolitis were randomly divided into experimental group and control group. There were 91 cases in the experimental group (61 males, 30 females) and 99 cases in the control group (70 males and 29 females). All the children in the experimental group were treated with antiinfective therapy after admission, and vitamin D supplementation was started for 1 month. All the control groups were treated with anti-infection after admission, the treatment method was the same as the experimental group. The clinical symptom remission time and hospitalization days were recorded, and the serum levels of 25-OHD3 IgA- IgA- IgA- CD 4, T 8, CD 8 / CD 8 were measured before treatment. The patients in the two groups were followed up for 3 months, and 3 months later, the patients in the two groups were followed up for 3 months, and the patients in the two groups were followed up for 3 months. To review the relevant indicators and count the number of recurrence in the two groups. Results before treatment, the levels of serum 25-hydroxyvitamin D _ 3 (25-OHD3) IgG, CD4 CD8 ~ + CD4 / CD8 were not significantly different between the experimental group and the control group (P0.05). After treatment, the level of serum IgA,IgG in the experimental group was higher than that before treatment (P0.05), but the serum ALP level was not significantly different from that before treatment (P0.05). After treatment, the serum ALP,IgA,IgG, CD4 CD8 + CD4 / CD8 level of the experimental group was higher than that of the control group. The levels of CD4 / CD8 in the experimental group were significantly higher than those in the control group (P0.05), but there was no significant difference in serum ALP,CD8 (P0.05). The days of hospitalization and symptom relief in the experimental group were shorter than those in the control group, the difference was statistically significant (P0.05), and the number of relapse after discharge was less than that in the control group (P0.05). Conclusion Vitamin D can affect the prevention and treatment of bronchiolitis through the regulation of immune function, and it plays an active role in the prevention and treatment of bronchiolitis.
【學(xué)位授予單位】：新疆醫(yī)科大學(xué)
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2014
【分類號】：R725.6

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