兒童腎病綜合征腎組織病理免疫熒光分型和病理類型與激素療效關(guān)系
發(fā)布時間：2018-09-05 14:45
【摘要】：目的分析腎組織病理免疫熒光分型和病理類型及激素療效的相關(guān)性。方法回顧性分析1990年1月至2015年12月臨床診斷為腎病綜合征(NS)并行腎穿刺活檢患兒的腎組織病理及臨床隨訪資料。結(jié)果 252例NS患兒的年齡分布為0.8~15歲,男女比例為3.94:1。腎組織病理免疫熒光類型分布為:IgA為主型13例(5.16%),Ig M為主型78例(30.95%),補體為主型19例(7.54%),IgG+A+M型17例(6.75%),Ig G+A+M+補體型22例(8.73%),IgA+補體型2例(0.79%),Ig M+補體型55例(21.83%),無免疫復合物型46例(18.25%);腎組織病理類型中輕微病變(MCNS)157例(62.3%),系膜增生性腎小球腎炎(Ms PGN)35例(13.89%),局灶節(jié)段腎小球硬化(FSGS)60例(23.81%)。使用激素4周內(nèi)完全緩解167例(77.31%),部分緩解31例(14.35%),激素無效18例(8.33%)。8種不同病理免疫熒光分型患兒的病理類型分布差異有統(tǒng)計學意義(χ~2=31.308,P=0.001),但激素療效差異無統(tǒng)計學意義(P0.05)。結(jié)論不同病理免疫熒光分型的病理類型分布有差異,提示免疫熒光沉積情況對NS臨床評估可能有一定價值。
[Abstract]:Objective to analyze the correlation between renal histopathological immunofluorescence classification, pathological type and hormone therapeutic effect. Methods from January 1990 to December 2015, renal histopathology and clinical follow-up data of children with nephrotic syndrome (NS) and renal biopsy were retrospectively analyzed. Results the age distribution of 252 cases with NS was 0.815 years old, the ratio of male to female was 3.94: 1. There were 13 cases (5.16%) of IgA predominant type in renal tissues, 78 cases (30.95%) of IgM predominant type, 19 cases (7.54%) of complement predominant type, 17 cases (6.75%) of Ig G A M M type, 22 cases (8.73%) of Ig G A M type, 2 cases (0.79%) of Ig M complement type, 55 cases (21.83%) of Ig M complement type. There were 46 cases (18.25%) of type A, 157 cases (62.3%) of (MCNS), 35 cases (13.89%) of Mesangial proliferative glomerulonephritis and 60 cases (23.81%) of (FSGS) of focal segmental glomerulosclerosis. Within 4 weeks, 167 cases (77.31%) had complete remission, 31 cases (14.35%) had partial remission, 18 cases (8.33%) had no hormone failure, and there were significant differences in the distribution of pathological types of 8 different types of pathological immunofluorescence (蠂 ~ (2 +) ~ (31.308) P ~ (0. 001), but there was no significant difference in the effect of hormone (P0.05). Conclusion there are differences in the distribution of pathological types among different pathological immunofluorescence types, suggesting that immunofluorescence deposition may be of some value in the clinical evaluation of NS.
【作者單位】： 上海交通大學醫(yī)學院附屬新華醫(yī)院小兒腎臟內(nèi)科;
【分類號】：R726.9
，
本文編號：2224597
[Abstract]:Objective to analyze the correlation between renal histopathological immunofluorescence classification, pathological type and hormone therapeutic effect. Methods from January 1990 to December 2015, renal histopathology and clinical follow-up data of children with nephrotic syndrome (NS) and renal biopsy were retrospectively analyzed. Results the age distribution of 252 cases with NS was 0.815 years old, the ratio of male to female was 3.94: 1. There were 13 cases (5.16%) of IgA predominant type in renal tissues, 78 cases (30.95%) of IgM predominant type, 19 cases (7.54%) of complement predominant type, 17 cases (6.75%) of Ig G A M M type, 22 cases (8.73%) of Ig G A M type, 2 cases (0.79%) of Ig M complement type, 55 cases (21.83%) of Ig M complement type. There were 46 cases (18.25%) of type A, 157 cases (62.3%) of (MCNS), 35 cases (13.89%) of Mesangial proliferative glomerulonephritis and 60 cases (23.81%) of (FSGS) of focal segmental glomerulosclerosis. Within 4 weeks, 167 cases (77.31%) had complete remission, 31 cases (14.35%) had partial remission, 18 cases (8.33%) had no hormone failure, and there were significant differences in the distribution of pathological types of 8 different types of pathological immunofluorescence (蠂 ~ (2 +) ~ (31.308) P ~ (0. 001), but there was no significant difference in the effect of hormone (P0.05). Conclusion there are differences in the distribution of pathological types among different pathological immunofluorescence types, suggesting that immunofluorescence deposition may be of some value in the clinical evaluation of NS.
【作者單位】： 上海交通大學醫(yī)學院附屬新華醫(yī)院小兒腎臟內(nèi)科;
【分類號】：R726.9
，
本文編號：2224597
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