彌散加權(quán)成像與彌散張量成像在兒童腦積水中的應(yīng)用價值
發(fā)布時間：2018-08-31 15:39
【摘要】：目的 利用彌散加權(quán)成像(diffusion weight imaging, DWI)及彌散張量成像(diffusion-tensor imaging, DTI)序列對兒童腦積水患兒雙側(cè)腦室周圍腦白質(zhì)及胼胝體壓部、膝部內(nèi)水分子彌散運(yùn)動情況和各向異性進(jìn)行研究,探討DWI與DTI對兒童梗阻性腦積水的應(yīng)用價值。 材料與方法 選取20例無神經(jīng)系統(tǒng)及運(yùn)動障礙疾病的正常兒童志愿者作為對照組,33例經(jīng)手術(shù)治療的由導(dǎo)水管狹窄或腫瘤造成的明顯梗阻性腦積水患兒為實驗組。正常對照組及HIE病例組均使用GE Signa EXCITE HD3.0T超導(dǎo)磁共振掃描儀,采用頭線圈。使用MRI常規(guī)序列(橫斷位T1WI、T2WI、FLAIR、矢狀位T2WI)及DWI序列、DTI序列掃描,在ADW4.0工作站上利用Functiontool軟件分別對病例進(jìn)行DWI及DTI后處理,重建出ADC圖、MD圖、FA圖、RA圖、VR圖、AI圖及纖維束圖。記錄相關(guān)所測定參數(shù)并應(yīng)用SPSS13.0軟件進(jìn)行統(tǒng)計分析,將兩組數(shù)據(jù)進(jìn)行正態(tài)檢驗并進(jìn)行兩樣本t檢驗,P0.05被認(rèn)為差異有統(tǒng)計意義。結(jié)果 20例兒童志愿者及33例腦積水患兒分別測量雙側(cè)側(cè)腦室周圍腦白質(zhì)、胼胝體膝部及壓部區(qū)域的DWI及DTI所測得的參數(shù)ADC、MD、FA、RA、VR及AI。利用SPSS13.0統(tǒng)計學(xué)軟件進(jìn)行統(tǒng)計學(xué)分析,所有數(shù)據(jù)經(jīng)過正態(tài)分布檢驗,符合正態(tài)分布,經(jīng)過獨立樣本t檢驗。ADC圖中胼胝體膝部兩組ADC值差異具有統(tǒng)計學(xué)意義,p0.05。胼胝體壓部RA值有統(tǒng)計學(xué)差異,p0.05，胼胝體膝部兩組間所有測得DTI各參數(shù)值均無統(tǒng)計學(xué)差異,雙側(cè)側(cè)腦室周圍腦白質(zhì)所測得MD、FA、VR、AI值均有統(tǒng)計學(xué)意義,p0.05。 結(jié)論 1、DWI和DTI可以有效地檢測出兒童腦積水中的胼胝體膝部ADC值、壓部RA值以及雙側(cè)側(cè)腦室周圍腦白質(zhì)MD、FA、VR、AI值的異常改變。 2、DWI和DTI具有無創(chuàng)、安全可靠的特點,是目前診斷兒童腦積水比較理想的MR檢查方法。 3、常規(guī)MRI、DWI和DTI聯(lián)合應(yīng)用,可以全面且準(zhǔn)確地評價兒童腦積水,為腦積水的診斷及鑒別診斷提供有力依據(jù)。
[Abstract]:Objective to study the diffusion motion and anisotropy of water molecules in bilateral periventricular white matter and corpus callosum in children with hydrocephalus by using diffusion weighted imaging (diffusion weight imaging, DWI) and diffusion-weighted Zhang Liang imaging (diffusion-tensor imaging, DTI). To investigate the value of DWI and DTI in children with obstructive hydrocephalus. Materials and methods 20 normal children without neurological and motor disorders were selected as control group. 33 children with obstructive hydrocephalus caused by aqueduct stenosis or tumor were selected as experimental group. GE Signa EXCITE HD3.0T superconducting magnetic resonance scanner and head coil were used in normal control group and HIE case group. Using MRI routine sequence (T1WIT2WIFLAIRT, sagittal T2WI) and DWI sequence, DWI and DTI postprocessing were performed on ADW4.0 workstation respectively, and the AI and fibrobundle images of RA / RA / RA were reconstructed by Functiontool software on ADW4.0 workstation. The correlation parameters were recorded and analyzed by SPSS13.0 software. The two groups of data were tested by normal and t-test of two samples. P0.05 was considered to have statistical significance. Results the parameters of ADC,MD,FA,RA,VR and AI. were measured by DWI and DTI in bilateral periventricular white matter, genu of corpus callosum and splenium in 20 children volunteers and 33 children with hydrocephalus. All the data were tested by normal distribution and accorded with normal distribution. The difference of ADC value between the two groups in the genu of corpus callosum was statistically significant after t-test of independent sample. The RA value of corpus callosum was significantly different between the two groups (p0.05). There was no significant difference in all the parameters of DTI between the two groups. The MD,FA,VR,AI values of bilateral periventricular white matter were statistically significant (P 0.05). Conclusion 1DWI and DTI can effectively detect the abnormal changes of ADC value in the genu of corpus callosum, RA value of the superior part of the corpus callosum and the MD,FA,VR,AI value of the white matter around the ventricle in children with hydrocephalus. 2DWI and DTI are noninvasive, safe and reliable. It is an ideal MR method for the diagnosis of hydrocephalus in children at present. (3) the combination of conventional MRI,DWI and DTI can evaluate hydrocephalus in children comprehensively and accurately, and provide a powerful basis for the diagnosis and differential diagnosis of hydrocephalus.
【學(xué)位授予單位】：山東大學(xué)
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2013
【分類號】：R445.2;R742.7
本文編號：2215432
[Abstract]:Objective to study the diffusion motion and anisotropy of water molecules in bilateral periventricular white matter and corpus callosum in children with hydrocephalus by using diffusion weighted imaging (diffusion weight imaging, DWI) and diffusion-weighted Zhang Liang imaging (diffusion-tensor imaging, DTI). To investigate the value of DWI and DTI in children with obstructive hydrocephalus. Materials and methods 20 normal children without neurological and motor disorders were selected as control group. 33 children with obstructive hydrocephalus caused by aqueduct stenosis or tumor were selected as experimental group. GE Signa EXCITE HD3.0T superconducting magnetic resonance scanner and head coil were used in normal control group and HIE case group. Using MRI routine sequence (T1WIT2WIFLAIRT, sagittal T2WI) and DWI sequence, DWI and DTI postprocessing were performed on ADW4.0 workstation respectively, and the AI and fibrobundle images of RA / RA / RA were reconstructed by Functiontool software on ADW4.0 workstation. The correlation parameters were recorded and analyzed by SPSS13.0 software. The two groups of data were tested by normal and t-test of two samples. P0.05 was considered to have statistical significance. Results the parameters of ADC,MD,FA,RA,VR and AI. were measured by DWI and DTI in bilateral periventricular white matter, genu of corpus callosum and splenium in 20 children volunteers and 33 children with hydrocephalus. All the data were tested by normal distribution and accorded with normal distribution. The difference of ADC value between the two groups in the genu of corpus callosum was statistically significant after t-test of independent sample. The RA value of corpus callosum was significantly different between the two groups (p0.05). There was no significant difference in all the parameters of DTI between the two groups. The MD,FA,VR,AI values of bilateral periventricular white matter were statistically significant (P 0.05). Conclusion 1DWI and DTI can effectively detect the abnormal changes of ADC value in the genu of corpus callosum, RA value of the superior part of the corpus callosum and the MD,FA,VR,AI value of the white matter around the ventricle in children with hydrocephalus. 2DWI and DTI are noninvasive, safe and reliable. It is an ideal MR method for the diagnosis of hydrocephalus in children at present. (3) the combination of conventional MRI,DWI and DTI can evaluate hydrocephalus in children comprehensively and accurately, and provide a powerful basis for the diagnosis and differential diagnosis of hydrocephalus.
【學(xué)位授予單位】：山東大學(xué)
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2013
【分類號】：R445.2;R742.7
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