【摘要】：目的:探究抽動癥患兒血清中鉛、銅、鋅、鐵和鎂的水平變化,血清中鉛、銅、鋅、鐵和鎂與抽動癥之間的相關(guān)性。方法:選擇2012年1月至2016年12月在我院門診接收治療的抽動癥患兒200例,選擇同期在我院進行健康體檢的兒童100例。按照兒童是否患有抽動癥,將研究對象分為抽動癥組和對照組;按照患兒的性別,將抽動癥患兒分為男性抽動癥組和女性抽動癥組;按照患兒的年齡,將抽動癥患兒分為幼齡組、學(xué)齡前組、學(xué)齡組;按照患兒抽動癥嚴重程度,將抽動癥患兒分為輕微抽動癥組、輕度抽動癥組、中度抽動癥組、明顯抽動癥組和嚴重抽動癥組。用原子吸收光譜儀對各組研究對象血清中的鉛、銅、鋅、鐵、和鎂水平進行檢測。對比各組研究對象血清中鉛、銅、鋅、鐵、和鎂水平,用Logistic回歸分析,分析血清中鉛、銅、鋅、鐵、和鎂與抽動癥之間的相關(guān)性。結(jié)果:(1)抽動癥組和對照組的一般臨床資料沒有顯著性差異(P0.05);(2)抽動癥組患兒血清中的鉛、鋅和鐵水平與對照組有顯著性差異(P0.05),抽動癥組患兒血清中銅、鎂水平與對照組沒有顯著性差異(P0.05);(3)抽動癥組患兒鉛、鋅和鐵檢測值偏于正常值發(fā)生率顯著性的高于對照組(P0.05);(4)幼齡組、學(xué)齡前組和學(xué)齡組患兒血清中的鉛、銅、鋅、鐵和鎂水平與對照組沒有顯著性差異(P0.05);(5)男性抽動癥組和女性抽動癥組患兒血清中的鉛、銅、鋅、鐵和鎂水平與對照組沒有顯著性差異(P0.05);(6)輕微沖動癥組、輕度抽動癥組、中度抽動癥組、明顯抽動癥組和嚴重抽動癥組患兒血清中的鉛、鋅和鐵水平有顯著性差異(P0.05),輕微沖動癥組、輕度抽動癥組、中度抽動癥組、明顯抽動癥組和嚴重抽動癥組患兒血清中的銅和鎂水平?jīng)]有顯著性差異(P0.05);(7)低水平的鋅和鐵是兒童發(fā)生抽動癥的危險因素,高水平的鉛是兒童發(fā)生抽動癥的危險因素。結(jié)論:(1)抽動癥患兒血清中的血鉛水平高于正常兒童,過高的血鉛水平是兒童發(fā)生抽動癥的危險因素;(2)抽動癥患兒血清中的鋅和鐵水平低于正常兒童,過低的血鋅和血鐵水平是兒童發(fā)生抽動癥的危險因素;(3)抽動癥患兒血清中的銅、鎂水平與正常兒童沒有顯著性的差。
[Abstract]:Objective: to investigate the relationship between serum lead, copper, zinc, iron and magnesium levels and serum lead, copper, zinc, iron and magnesium levels in children with tic disorder. Methods: from January 2012 to December 2016, 200 children with tic disorder were selected and 100 children who underwent physical examination in our hospital from January 2012 to December 2016 were selected. According to whether the child has tic disorder or not, the subjects of the study are divided into two groups: the children with tic disorder and the control group; the children with tic disorder are divided into the male group and the female group according to the sex of the child; according to the age of the child, Children with tic were divided into young group, preschool group and school age group. According to the severity of the children's tic disorder, children with tic disorder were divided into mild tic group, moderate tic group, obvious tic group and severe tic group. The levels of lead, copper, zinc, iron and magnesium in serum of each group were determined by atomic absorption spectrometer. The levels of lead, copper, zinc, iron, and magnesium in serum of each group were compared. The correlation of lead, copper, zinc, iron and magnesium with tic was analyzed by Logistic regression analysis. Results: (1) there was no significant difference in general clinical data between the tic group and the control group (P0.05); (2). The levels of lead, zinc and iron in the serum of the children with tic disorder were significantly different from those in the control group (P0.05). There was no significant difference in magnesium level between the control group and the control group (P0.05); (3). The incidence of lead, zinc and zinc in the children with tic disorder was significantly higher than that in the control group (P0.05); (4), the lead, copper, zinc in the serum of preschool group and school age group. There was no significant difference in serum lead, copper, zinc, iron and magnesium levels between male and female patients with tic disorder and control group (P0.05); (5). There was no significant difference in serum levels of lead, copper, zinc, iron and magnesium between male and female patients (P0.05); (6). There were significant differences in serum lead, zinc and iron levels in moderate tic group, obvious tic group and severe tic group (P0.05), mild impulsive disorder group, mild tic disorder group, moderate tic syndrome group, and moderate tic group. There was no significant difference in serum copper and magnesium levels between children with severe tic disorder and those with obvious tic disorder (P0.05); (7). Low levels of zinc and iron were risk factors for children with tic disorder, and high levels of lead were risk factors for children with THD. Conclusion: (1) the serum lead level in children with tic disorder is higher than that in normal children, and the high level of blood lead is the risk factor of children with tic disorder, (2) the serum zinc and iron levels in children with tic disorder are lower than those in normal children. Low serum zinc and iron levels were the risk factors for children with tic. (3) there was no significant difference in serum copper and magnesium levels between children with tic disorder and normal children.
【學(xué)位授予單位】：山東大學(xué)
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2017
【分類號】：R749.94

【相似文獻】

相關(guān)期刊論文 前10條

1 駱金璽,楊富勝,徐敏,賈會勤;電視性抽動癥21例[J];新醫(yī)學(xué);2002年06期

2 歐陽穎;鋅硒寶佐治小兒抽動癥的觀察[J];重慶醫(yī)學(xué);2002年08期

3 劉紅;;自擬鉤蟬平抽飲治療小兒抽動癥36例[J];云南中醫(yī)中藥雜志;2007年12期

4 王智雄;劉華清;;小兒抽動癥 家長怎么辦[J];家庭醫(yī)學(xué);2014年04期

5 ;患抽動癥能上學(xué)嗎[J];家庭與家教;2005年10期

6 楊眉;為抽動癥的孩子解憂愁[J];心理與健康;1994年02期

7 ; 談?wù)労⒆拥亩鄤影Y和抽動癥[J];現(xiàn)代家教;2002年08期

8 ;談?wù)労⒆拥亩鄤影Y和抽動癥[J];現(xiàn)代家教;2002年10期

9 ;多動癥、抽動癥——隱藏在孩子身上的大敵[J];現(xiàn)代家教;2002年11期

10 徐秀春;抽動癥9例腦電圖及臨床分析與體會[J];邯鄲醫(yī)學(xué)高等�？茖W(xué)校學(xué)報;2001年05期

相關(guān)會議論文 前7條

1 楊軍;;天真定抽湯治療抽動癥37例[A];浙江省中西醫(yī)結(jié)合學(xué)會神經(jīng)內(nèi)科專業(yè)委員會第五次學(xué)術(shù)研討會中西醫(yī)結(jié)合神經(jīng)內(nèi)科學(xué)習(xí)班資料匯編[C];2006年

2 馮曉純;白春麗;;家長您的孩子患了抽動癥該怎么辦?[A];2009年全國中醫(yī)藥科普高層論壇論文集[C];2009年

3 蔡定芳;;抽動癥的中西醫(yī)結(jié)合研究[A];第三屆全國中西醫(yī)結(jié)合神經(jīng)系統(tǒng)疾病學(xué)術(shù)會議論文集[C];2000年

4 史建鋼;;天麻熄風(fēng)膠囊治療癲癇、抽動癥臨床研究[A];第28次全國中醫(yī)兒科學(xué)術(shù)大會暨2011年名老中醫(yī)治療（兒科）疑難病臨床經(jīng)驗高級專修班論文匯編[C];2011年

5 史建鋼;梁靚;;天麻熄風(fēng)膠囊治療癲癇病、抽動癥臨床研究[A];甘肅省中醫(yī)藥學(xué)會2010年會員代表大會暨學(xué)術(shù)年會論文匯編[C];2010年

6 孫孝登;;抽動—穢語綜合癥中醫(yī)治療[A];第24屆全國中醫(yī)兒科學(xué)術(shù)研討會、中醫(yī)藥高等教育兒科教學(xué)研討會、兒科名中醫(yī)講習(xí)班論文匯編[C];2007年

7 楊雨蒙;王建敏;;王建敏主任兒科臨床常用藥對拾萃[A];第二十九次全國中醫(yī)兒科學(xué)術(shù)大會暨“小兒感染性疾病的中醫(yī)藥防治”培訓(xùn)班論文匯編[C];2012年

相關(guān)重要報紙文章 前10條

1 本報記者 王凱;孩子“太淘氣”可能是病 多動抽動癥兒童需要治療[N];中國婦女報;2013年

2 芊芊雁;如何識別隱性多動和抽動癥[N];解放日報;2014年

3 芊芊雁;及時診斷 遠離抽動癥[N];解放日報;2014年

4 唐文;嚼嚼口香糖預(yù)防抽動癥[N];大眾衛(wèi)生報;2004年

5 唐洪麗 程守勤;春暖花開兒童頻發(fā)抽動癥[N];健康報;2006年

6 陶海;多動癥和抽動癥有何不同[N];健康報;2007年

7 本報記者 王樂羊;對抽動癥、多動癥患兒理解與治療同樣重要[N];中國中醫(yī)藥報;2002年

8 北京安定醫(yī)院兒科 崔永華;小兒壞毛病 抽動癥作怪[N];健康報;2013年

9 芊芊雁;及時診斷，遠離抽動癥[N];解放日報;2014年

10 芊芊雁;孩子愛“罵人”或患抽動癥[N];解放日報;2014年

相關(guān)碩士學(xué)位論文 前5條

1 趙艷艷;微量元素和血鉛的變化對抽動癥患兒的影響分析[D];山東大學(xué);2017年

2 何大雪;中醫(yī)治療抽動癥現(xiàn)狀及其與過敏相關(guān)性的研究[D];成都中醫(yī)藥大學(xué);2014年

3 王艷;中西醫(yī)結(jié)合健康教育在抽動癥患兒及其照顧者中的應(yīng)用研究[D];成都中醫(yī)藥大學(xué);2014年

4 代衛(wèi)鋒;小兒抽動癥合并多動癥的中醫(yī)證治及臨床研究[D];南京中醫(yī)藥大學(xué);2013年

5 朱松文;宋鐵玎教授治療小兒抽動癥經(jīng)驗淺探[D];遼寧中醫(yī)藥大學(xué);2014年

，

本文編號：2179826