【摘要】：目的探討外貌評分與女性青少年系統性紅斑狼瘡(systemic lupus erythematosus, SLE)患者抑郁癥狀之間的關系。 方法選取42名青少年女性SLE患者作為患者組,40名年齡段相同的女性受試者作為對照組,對患者組及對照組受試者實施問卷調查。調查內容包括系統性紅斑狼瘡疾病活動性指數(systemic lupus erythematosis disease activity index, SLEDAI)量表評價SLE疾病嚴重程度,兒童抑郁量表(children's depression inventory, CDI)評價兒童抑郁情況,兒童自我感知量表(self-perception profile for children, SPPC)中的外貌評價項目進行外貌評分。所有的分析均采用SPSS10.0進行數據分析。t檢驗比較正態(tài)分布數據差異,Spearman相關分析進行相關性研究,多分類有序Logistic回歸分析,p0.05定義為顯著性差異,檢驗水準α=0.05。 結果患者組中幾乎所有的患者均表現出不同程度的抑郁癥狀。患者組CDI總分平均為18.5±4.3,38.1%(16／42)的患者CDI大于19分。對照組CDI分數顯著低于患者組(11.4±1.7vs.18.54±4.3,p0.05)。92.9%(39／42)的SLE患者表示因為SLE而變得對自身相貌不滿意。這些患者中,SPPC外貌得分為13.0±2.8,而對照組兒童外貌評價得分為20.0±3.1(p0.05)。單因素Pearson相關分析評價年齡、病程、SLEDAI評分、住院次數、外貌評分及CDI評分之間的關系。外貌評分與抑郁癥狀高度相關(r=-0.758,p=0.001),其他因素如病程、SLEDAI評分及住院次數儀與抑郁癥狀部分相關。狼瘡腦病組患兒與非狼瘡腦病組患兒抑郁癥狀發(fā)病率無顯著區(qū)別。 結論外貌改變與青少年女性SLE患者出現抑郁癥狀有較為顯著的相關性,提示我們在治療時應充分重視緩解與外貌相關的癥征,盡可能減少各種治療對外貌帶來的影響,并應加強此方面的心理輔導。此外,狼瘡腦病與患兒抑郁癥狀無顯著關聯。
[Abstract]:Objective to investigate the relationship between appearance score and depressive symptoms in female adolescent patients with systemic lupus erythematosus (systemic lupus erythematosus, SLE). Methods 42 adolescent female SLE patients were selected as the control group and 40 female subjects of the same age group as the control group. The subjects in the patient group and the control group were investigated by questionnaire. The contents of the investigation included the evaluation of the severity of SLE disease with the activity index of systemic lupus erythematosus (systemic lupus erythematosis disease activity index, SLEDAI) and the evaluation of depression in children with (children's depression inventory, CDI). Children's self-perception scale (self-perception profile for children, SPPC) was used to evaluate appearance. All the analyses were carried out by SPSS10.0 data analysis. T test was used to compare the normal distribution data difference and Spearman correlation analysis. The multi-classification ordered Logistic regression analysis was defined as significant difference, and the test level was 偽 0.05. Results almost all patients in the patient group showed different degree of depression. The average total score of CDI in patients was 18.5 鹵4.3 鹵38.1% (16 / 42), CDI was greater than 19. CDI scores in the control group were significantly lower than those in the patient group (11.4 鹵1.7vs.18.54 鹵4.3 p0.05). 92.9% (39 / 42) of SLE patients indicated that they were not satisfied with their appearance because of SLE. In these patients, the SPPC appearance score was 13.0 鹵2.8, while that in the control group was 20.0 鹵3.1 (p0.05). Univariate Pearson correlation analysis was used to evaluate the relationship between age, course of disease and SLEDAI score, hospitalization frequency, appearance score and CDI score. There was a high correlation between appearance score and depression symptoms (r = -0.758p0. 001). Other factors, such as the SLEDAI score of course of disease and the frequency of hospitalization, were partly related to depression symptoms. There was no significant difference in the incidence of depressive symptoms between children with lupus encephalopathy and those with non-lupus encephalopathy. Conclusion there is a significant correlation between appearance changes and depressive symptoms in adolescent female SLE patients, which suggests that we should pay more attention to alleviating the symptoms associated with appearance and minimize the effects of various treatments on appearance. Psychological counseling in this area should be strengthened. In addition, there was no significant association between lupus encephalopathy and depressive symptoms in children.
【學位授予單位】：北京協和醫(yī)學院
【學位級別】：碩士
【學位授予年份】：2012
【分類號】：R725.9

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