【摘要】：目的:了解中國0~6歲兒童孤獨癥譜系障礙(autism spectrum disorders,ASD)流行現(xiàn)狀及趨勢。方法:在Pubmed、Web of Science、Scopus、相關(guān)期刊論文(CNKI)、萬方數(shù)據(jù)庫、維普數(shù)據(jù)庫(VIP)和中國生物醫(yī)學(xué)文獻(xiàn)數(shù)據(jù)庫(CBM)檢索于2017年2月25日之前發(fā)表的關(guān)于中國0~6歲兒童孤獨癥譜系障礙及其亞型患病率研究的文獻(xiàn),按照設(shè)定的納入和診斷標(biāo)準(zhǔn)進(jìn)行篩選。采用隨機(jī)效應(yīng)模型合并不同時期和不同性別兒童患病率數(shù)據(jù),并根據(jù)數(shù)據(jù)來源、年齡、篩查和診斷工具、文獻(xiàn)質(zhì)量進(jìn)行亞組分析。結(jié)果:共有9篇ASD患病率文獻(xiàn)和20篇孤獨癥(autism or autistic disorder,AD)患病率文獻(xiàn)納入研究。2006—2010年和2011—2015年0~6歲兒童AD合并患病率分別為1.74‰(95%CI:1.12‰~2.69‰)和1.80‰(95%CI:1.33‰~2.43‰),差異無統(tǒng)計學(xué)意義(P=0.898),但均顯著高于1996—2005年合并患病率0.94‰(95%CI:0.67‰~1.33‰)(P=0.031;P=0.005)。0~6歲兒童ASD合并患病率在2006—2010年和2011—2015年分別為3.52‰(95%CI:1.48‰~8.34‰)和3.48‰(95%CI:1.77‰~6.84‰),差異未見統(tǒng)計學(xué)意義(P=0.983)。不同性別ASD和AD患病率在不同時期差異均無統(tǒng)計學(xué)意義。合并得到2006—2015年0~6歲兒童ASD和AD患病率分別為3.51‰(95%CI:2.15‰~5.74‰)和1.77‰(95%CI:1.40‰~2.24‰),男女患病率比分別為2.59∶1和3.63∶1。亞組分析提示月齡和文獻(xiàn)質(zhì)量與ASD或AD合并患病率相關(guān)。結(jié)論:2006—2015年中國0~6歲兒童ASD和AD患病率均保持穩(wěn)定,相比2005年以前是否呈上升趨勢難以定論。建議開展全國代表性兒童早期ASD和AD現(xiàn)況調(diào)查與監(jiān)測,準(zhǔn)確估計ASD及AD流行現(xiàn)狀和趨勢。
[Abstract]:Objective: to investigate the prevalence and trend of autism spectrum disorders (autism spectrum disorders) in 6 year old children in China. Methods: the Chinese Journal Full-text Database (CNKI) and Wanfang Database were used in Pubmedus Web of Science Scopus. Weip Database (VIP) and Chinese Biomedical Literature Database (CBM) were used to retrieve the literature published before February 25, 2017 on the prevalence of autism spectrum disorders and their subtypes in Chinese 0- and 6-year-old children. Screen according to established inclusion and diagnostic criteria. The random effect model was used to combine the prevalence data of children of different periods and different genders, and subgroup analysis was carried out according to the data source, age, screening and diagnostic tools, and literature quality. Results: a total of 9 articles on the prevalence of ASD and 20 articles on the prevalence of (autism or autistic disorderosis AD were included in the study. The prevalence rate of AD in children aged 6 years from 2006 to 2010 and from 2011 to 2015 was 1.74 鈥，

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