本文選題：抽動(dòng)障礙 + 兒童　； 參考：《中國(guó)人民解放軍醫(yī)學(xué)院》2012年碩士論文

【摘要】：目的：抽動(dòng)障礙（Tic Disorders, TD）病因尚不明確，本文通過對(duì)抽動(dòng)障礙患兒血清總IgE抗體和過敏原特應(yīng)性IgE（sIgE）抗體進(jìn)行檢測(cè)，探討抽動(dòng)障礙與變態(tài)反應(yīng)的關(guān)系。 方法：本課題采用病例對(duì)照研究，對(duì)72例抽動(dòng)障礙患兒和50例變態(tài)反應(yīng)性疾�。ˋllergic Disorders, AD）患兒進(jìn)行病史采集和血清總IgE、sIgE檢測(cè)。分別收集TD組和AD組兒童靜脈血3毫升，采用歐蒙醫(yī)學(xué)實(shí)驗(yàn)診斷股份公司的特應(yīng)性過敏原中國(guó)組合3檢測(cè)試劑盒（歐蒙印跡法）進(jìn)行總IgE、吸入性和食物過敏原sIgE抗體的檢測(cè)，對(duì)數(shù)據(jù)進(jìn)行統(tǒng)計(jì)學(xué)分析。 結(jié)果：TD組患兒年齡為3～15歲，，平均年齡（8.88±2.75）歲，男孩明顯多于女孩。TD患兒84.7%以眼部、鼻咽喉部癥狀起病。TD組兒童血清總IgE抗體陽(yáng)性者為61例，陽(yáng)性率為84.72％，AD組兒童血清總IgE抗體陽(yáng)性44例，陽(yáng)性率為88％；TD組兒童血清過敏原sIgE檢測(cè)陽(yáng)性50例，陽(yáng)性率為69.44％,AD組過敏原sIgE檢測(cè)陽(yáng)性37例，陽(yáng)性率為74％，兩組間血清總IgE和過敏原sIgE相比較差異均不顯著（p＞0.05）。兩組兒童血清總IgE抗體水平在不同等級(jí)中的分布無(wú)顯著性差異（p＞0.05）。抽動(dòng)障礙組常見的過敏原有屋塵、樹組合（榆樹/梧桐樹/柳樹/楊樹/柏樹）、塵螨組合（屋塵螨/粉塵螨）、淡水魚組合（鮭魚，鱸魚，鯉魚）、牛奶/巧克力混合，與變態(tài)反應(yīng)性疾病組相似。TD組和AD組≥2種過敏原sIgE陽(yáng)性檢出率相比，差別無(wú)統(tǒng)計(jì)學(xué)意義（p＞0.05）。TD組患兒總IgE等級(jí)分布與病程長(zhǎng)短無(wú)關(guān)。 結(jié)論：1.抽動(dòng)障礙患兒與變態(tài)反應(yīng)性疾病患兒的血清總IgE和sIgE抗體陽(yáng)性率在統(tǒng)計(jì)學(xué)上無(wú)顯著差異，抽動(dòng)障礙患兒血清總IgE水平在不同等級(jí)中的分布與變態(tài)反應(yīng)性疾病相類似。2.抽動(dòng)障礙與變態(tài)反應(yīng)性疾病有一定的相關(guān)性，機(jī)制尚待進(jìn)一步研究。
[Abstract]:Objective: the etiology of tic disorders (TD) is not clear. The relationship between tic disorders and allergic reaction was studied by detecting the total IgE antibody and the allergic IgE antibody in children with tic disorder. Methods: a case-control study was conducted in 72 children with tic disorders and 50 children with Allergic disorders (AD). Three milliliters of venous blood were collected from children in TD group and AD group respectively. The total IgE, inhaled and food allergen Siga E antibodies were detected by using the Allergic Allergen Chinese combination 3 Test Kit (OMEBlot) of Ormon Medical Experimental diagnosis Co., Ltd. The data were analyzed statistically. Results the age of the children in the group of 10% TD was 3 to 15 years old, the average age was (8.88 鹵2.75) years old. 84.7% of the children with TDs were more boys than girls. 61 cases of children in the group of onset of nasopharyngeal and larynx symptoms were positive for total IgE antibody in serum, and 61 cases were positive for IgE antibody in serum in the group of onset of nasopharynx symptoms. The positive rate of serum total IgE antibody was 44 in AD group, 50 in 88T group, and 37 in AD group, and the positive rate was 740.The positive rate was 84.72AD, and the positive rate was 84.72AD, the positive rate was 84.72AD. There was no significant difference in total IgE and Siga between the two groups (p > 0.05). There was no significant difference in the distribution of serum total IgE antibody between the two groups (p > 0.05). Common allergies to house dust, tree combinations (elm / sycamore / willow / poplar / cypress), dust mites (house dust mites / dust mites), freshwater fish (salmon, bass, carp), milk / chocolate mixture, There was no significant difference in the positive rate of Siga between the two groups (p > 0.05). The distribution of total IgE in TD group was not related to the duration of disease. Conclusion 1. The positive rates of serum total IgE and SiIgE antibodies in children with tic disorder and allergic disease were not significantly different. The distribution of serum total IgE in children with tic disorder in different grades was similar to that in allergic diseases. There is a certain correlation between tic disorder and allergic diseases, and the mechanism needs further study.
【學(xué)位授予單位】：中國(guó)人民解放軍醫(yī)學(xué)院
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2012
【分類號(hào)】：R749.94

【引證文獻(xiàn)】

相關(guān)碩士學(xué)位論文 前1條

1 王雪青;靜心制動(dòng)方治療抽動(dòng)障礙療效觀察及與神經(jīng)遞質(zhì)的相關(guān)研究[D];北京中醫(yī)藥大學(xué);2013年

本文編號(hào)：2107827