本文選題：心肌肌鈣蛋白 + 新生兒�。� 參考：《天津醫(yī)科大學(xué)》2017年碩士論文

【摘要】：目的:通過(guò)對(duì)新生兒高膽紅素血癥、新生兒感染性疾病及早產(chǎn)兒的心肌肌鈣蛋白Ⅰ(cTnⅠ)的水平測(cè)定,以探討心肌肌鈣蛋白Ⅰ在新生兒中的臨床意義。對(duì)象和方法:1.根據(jù)研究對(duì)象分類選取2015年1月至2016年8月期間天津醫(yī)科大學(xué)寶坻臨床學(xué)院新生兒科收治的180例新生兒作為研究對(duì)象,將上述新生兒分為足月高膽紅素血癥組、足月感染組、早產(chǎn)組三組,每組均為60例,選擇同期住院的因腭裂或母親為高齡產(chǎn)婦或母親有不良妊娠史的足月新生兒60例為對(duì)照組,對(duì)照組患兒經(jīng)住院觀察為健康新生兒(腭裂患兒無(wú)其他并發(fā)癥)。將上述新生兒均于住院當(dāng)日或次日用干燥管留取靜脈血3-4 m L送檢,采用化學(xué)發(fā)光免疫分析法分別對(duì)4組患兒進(jìn)行心肌肌鈣蛋白Ⅰ檢測(cè),比較4組之間的差異并作對(duì)比分析。2.選取2015年1月至2016年8月期間天津醫(yī)科大學(xué)寶坻臨床學(xué)院收治的80例高膽紅素血癥新生兒(HBN)作為研究對(duì)象,根據(jù)HBN分型標(biāo)準(zhǔn)將其分為輕度HBN組40例、重度HBN組40例,取靜脈血采用化學(xué)發(fā)光免疫分析法分別對(duì)2組患兒進(jìn)行心肌肌鈣蛋白Ⅰ檢測(cè),并采用全自動(dòng)生化分析儀檢測(cè)肝功能,指標(biāo)包括谷丙轉(zhuǎn)氨酶、總蛋白、白蛋白、總膽紅素、間接膽紅素等。3.選取2015年1月至2016年8月期間天津醫(yī)科大學(xué)寶坻臨床學(xué)院收治的80例高膽紅素血癥新生兒作為研究對(duì)象,根據(jù)是否溶血將其分為非溶血組40例、溶血組40例。取靜脈血采用化學(xué)發(fā)光免疫分析法分別對(duì)2組患兒進(jìn)行心肌肌鈣蛋I檢測(cè),并采用全自動(dòng)生化分析儀檢測(cè)肝功能,指標(biāo)包括谷丙轉(zhuǎn)氨酶、總蛋白、白蛋白、總膽紅素和間接膽紅素。結(jié)果:1.足月高膽紅素血癥組、足月感染組、早產(chǎn)組新生兒與對(duì)照組新生兒在性別、日齡、分娩方式和Apgar評(píng)分無(wú)統(tǒng)計(jì)學(xué)差異(P0.05),而心肌肌鈣蛋白Ⅰ檢測(cè)水平高于對(duì)照組,差異有統(tǒng)計(jì)學(xué)意義(P〈0.05)。2.足月高膽紅素血癥組新生兒心肌肌鈣蛋白Ⅰ檢測(cè)水平高于足月感染組、早產(chǎn)組新生兒,差異有統(tǒng)計(jì)學(xué)意義(P〈0.05)。足月感染組、早產(chǎn)組兩組新生兒心肌肌鈣蛋白Ⅰ(cTnⅠ)檢測(cè)水平差異無(wú)統(tǒng)計(jì)學(xué)意義(P0.05)。3.輕度高膽紅素血癥組與重度高膽紅素血癥組新生兒在性別、胎齡、日齡、分娩方式、羊水性質(zhì)、出生體重、身長(zhǎng)、頭圍和Apgar評(píng)分均無(wú)統(tǒng)計(jì)學(xué)差異(P0.05),兩組新生兒心肌肌鈣蛋白Ⅰ檢測(cè)水平差異亦無(wú)統(tǒng)計(jì)學(xué)意義(P0.05),且總膽紅素、間接膽紅素與心肌肌鈣蛋白無(wú)相關(guān)性。4.非溶血性高膽紅素血癥組與溶血性高膽紅素血癥組新生兒在性別、胎齡、日齡、分娩方式、羊水性質(zhì)、出生體重、身長(zhǎng)、頭圍和Apgar評(píng)分均無(wú)統(tǒng)計(jì)學(xué)差異(P0.05),兩組新生兒心肌肌鈣蛋I檢測(cè)水平差異亦無(wú)統(tǒng)計(jì)學(xué)意義(P0.05)。結(jié)論:1.高膽紅素血癥、感染、早產(chǎn)等高危因素對(duì)新生兒心肌肌鈣蛋白Ⅰ值的影響不同,其中高膽紅素血癥影響較大。2.高膽紅素血癥可引起心肌損害,但心肌肌鈣蛋白Ⅰ不隨膽紅素水平的升高而升高。3.溶血與非溶血因素造成的高膽紅素血癥均影響心肌肌鈣蛋白Ⅰ水平,但影響程度并無(wú)差異。
[Abstract]:Objective: To investigate the clinical significance of cardiac troponin I in newborn infants by measuring the level of neonatal hyperbilirubinemia, neonatal infectious diseases and premature infants' cardiac troponin I (cTn I). 1. according to the classification of the subjects from January 2015 to August 2016, the Baodi clinic of Medical University Of Tianjin was selected. 180 newborns treated in the new Department of pediatrics were divided into full term hyperbilirubinemia group, full term infection group and three group of premature delivery group, 60 cases in each group, and 60 full term newborns in the same period were selected as the control group because of cleft palate or mother or mother had a history of bad pregnancy. The hospitalized observation was healthy newborns (no other complications in children with cleft palate). All the newborns were left with 3-4 m L for venous blood on the day of hospitalization or daily use of dry tubes. The cardiac troponin I was detected by chemiluminescent immunoassay, and the differences between the 4 groups were compared and the comparison and analysis of the 4 groups were compared and analyzed in January 2015. 80 cases of hyperbilirubinemia (HBN) were treated in the Baodi Clinical College of Medical University Of Tianjin in August 2016 as the research object. According to the HBN classification standard, they were divided into 40 cases of mild HBN group and 40 cases of severe HBN group. The cardiac troponin I was detected by chemiluminescent immunoassay in 2 groups of children, and the use of chemiluminescence immunoassay was used to detect the cardiac troponin I. The automatic biochemical analyzer was used to detect liver function, including.3., total protein, albumin, total bilirubin, and indirect bilirubin in 80 cases of hyperbilirubinemia from January 2015 to August 2016 at the Baodi Clinical College of Medical University Of Tianjin, which were divided into non hemolytic group 40 according to whether hemolysis was hemolytic. 40 cases of hemolytic group were detected by chemiluminescence immunoassay in 2 groups. The I was detected in 2 groups of children, and the liver function was detected by automatic biochemical analyzer, including alanine aminotransferase, total protein, albumin, total bilirubin and indirect bilirubin. Fruit: 1. full term hyperbilirubinemia group, full term infection group, preterm delivery There was no statistical difference between the newborn and the control group in the sex, day of age, delivery mode and Apgar score (P0.05), but the detection level of cardiac troponin I was higher than that of the control group. The difference was statistically significant (P < 0.05) the detection level of cardiac muscle calcinin I in the neonates of.2. full term hyperbilirubinemia group was higher than that in the full term infection group. The difference was statistically significant (P < 0.05). There was no significant difference in the detection level of cardiac troponin I (cTn I) in the two groups of premature delivery group (P0.05) and there was no significant difference in the level of neonatal.3. mild hyperbilirubinemia group and severe hyperbilirubinemia group in sex, gestational age, age, mode of delivery, amniotic fluid, birth weight, body length, head circumference and There was no statistical difference in Apgar scores (P0.05). There was no significant difference between the two groups of neonatal cardiac troponin I detection (P0.05), and the total bilirubin, indirect bilirubin and cardiac troponin were not related to.4. non hemolytic hyperbilirubinemia group and hemolytic hyperbilinuremia group in the sex, gestational age, age, and childbirth. There was no statistical difference in the nature of amniotic fluid, birth weight, body length, head circumference and Apgar score (P0.05). There was no significant difference between the two groups of neonatal cardiac muscle calcium eggs (P0.05). Conclusion: the effects of high risk factors such as hyperbilirubinemia, infection, preterm birth and other high risk factors on neonatal cardiac troponin I value were different, in which hyperbilirubinemia was found. High.2. hyperbilirubinemia can cause myocardial damage, but cardiac troponin I does not increase with the increase of bilirubin level and the hyperbilirubinemia caused by.3. hemolysis and non hemolytic factors all affect the level of cardiac troponin I, but there is no difference in the degree of influence.
【學(xué)位授予單位】：天津醫(yī)科大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2017
【分類號(hào)】：R722.1

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