發(fā)布時(shí)間：2018-06-26 23:11

  本文選題：新生兒 + 真菌性敗血癥�。� 參考：《現(xiàn)代預(yù)防醫(yī)學(xué)》2017年05期

【摘要】：目的探討新生兒重癥監(jiān)護(hù)病房(NICU)真菌性敗血癥的醫(yī)院感染發(fā)病率、病原菌及危險(xiǎn)因素,以針對(duì)性的制定新生兒真菌性敗血癥感染防控策略。方法對(duì)2015年1月至2016年6月鄭州大學(xué)第一附屬醫(yī)院NICU收治的6962名患兒進(jìn)行回顧性研究,分析真菌性敗血癥醫(yī)院感染現(xiàn)狀;并采用多因素Logistic回歸探討真菌性敗血癥醫(yī)院感染的相關(guān)危險(xiǎn)因素。結(jié)果 NICU真菌性敗血癥醫(yī)院感染率為0.42%;血培養(yǎng)檢出真菌29例,主要檢出菌為白假絲酵母菌(37.93%),其次為菌膜假絲酵母菌(20.69%);單因素Logistic回歸分析顯示,早產(chǎn)兒、住院時(shí)間、抗菌藥使用時(shí)間、抗菌藥使用種類、極低出生體重兒、壞死性小腸結(jié)腸炎、中心靜脈置管時(shí)間及呼吸機(jī)使用時(shí)間,與真菌性敗血癥的發(fā)生呈正相關(guān)。多因素Logistic回歸分析表明,真菌性敗血癥的獨(dú)立危險(xiǎn)因素主要有早產(chǎn)兒(OR=5.975)和極低出生體重(OR=1.140)。結(jié)論本院NICU真菌性敗血癥醫(yī)院感染率接近全國(guó)水平;早產(chǎn)兒和極低出生體重兒是NICU真菌性敗血癥發(fā)生的高危人群。
[Abstract]:Objective to investigate the nosocomial infection rate, pathogenic bacteria and risk factors of fungal septicemia in neonatal intensive care unit (NICU). Methods from January 2015 to June 2016, a retrospective study was conducted on 6962 children in the ICU of the first affiliated Hospital of Zhengzhou University, and the nosocomial infection status of fungal septicemia was analyzed. The risk factors of nosocomial infection of fungal septicemia were analyzed by multivariate logistic regression. Results the nosocomial infection rate of fungal septicemia was 0.42% in NICU, 29 cases were detected by blood culture, the main bacteria were Candida albicans (37.93%), the next was Candida cerevisiae (20.69%). The time of use of antibiotics, kinds of antibiotics, very low birth weight infants, necrotic enterocolitis, central venous catheterization and ventilator use time were positively correlated with the occurrence of fungal septicemia. Multivariate logistic regression analysis showed that the main independent risk factors of fungal septicemia were premature infants (OR5.975) and very low birth weight (OR1.140). Conclusion the nosocomial infection rate of fungal septicemia in NICU is close to the national level, premature infants and very low birth weight infants are the high risk population of fungal septicemia in NICU.
【作者單位】： 鄭州大學(xué)第一附屬醫(yī)院感染管理科;
【基金】：河南省科技攻關(guān)計(jì)劃項(xiàng)目(162102310155)
【分類號(hào)】：R722.131

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