本文選題：過(guò)敏性紫癜 + 羥基維生素D_��； 參考：《中國(guó)當(dāng)代兒科雜志》2017年07期

【摘要】：目的探討血清維生素D水平與過(guò)敏性紫癜(HSP)患兒病情及治療的關(guān)系。方法選取2015年1~12月第1次診斷為HSP的患兒50例為HSP組,以49例健康兒童作為健康對(duì)照組�？崭共杉瘍山M兒童血清,采用ELISA法檢測(cè)血清25羥基維生素D_3[25-(OH)D_3]水平。根據(jù)25-(OH)D_3檢測(cè)結(jié)果將HSP患兒進(jìn)一步分為維生素D正常組(20 ng/m L)(n=9)、不足組(15 ng/m L~20 ng/m L)(n=15)、缺乏組(≤15 ng/m L)(n=25)、嚴(yán)重缺乏組(≤5 ng/m L)(n=1)。收集HSP患兒的一般資料、臨床表現(xiàn)、激素治療情況、入院前病程及住院天數(shù)進(jìn)行分析比較。結(jié)果 HSP組患兒血清25-(OH)D_3水平(16±6 ng/m L)低于健康對(duì)照組(29±5 ng/m L)(P0.01)。與正常組+不足組患兒[25-(OH)D_315 ng/m L]相比,缺乏組+嚴(yán)重缺乏組患兒[25-(OH)D_3≤15 ng/m L]腎臟受累發(fā)生率、激素使用率均增高(P0.05),中位住院天數(shù)延長(zhǎng)(P0.05),但入院前病程差異無(wú)統(tǒng)計(jì)學(xué)意義(P0.05)。結(jié)論 HSP患兒血清25-(OH)D_3水平低,低血清25-(OH)D_3水平HSP患兒腎臟受累風(fēng)險(xiǎn)及激素使用率增高,住院時(shí)間延長(zhǎng)。但補(bǔ)充維生素D對(duì)HSP有無(wú)治療作用,能否縮短HSP患兒病程,改善遠(yuǎn)期預(yù)后,仍有待進(jìn)一步研究。
[Abstract]:Objective to investigate the relationship between serum vitamin D level and the condition and treatment of children with anaphylactoid purpura (HSP). Methods 50 children diagnosed as HSP in 2015 1~12 month were HSP group and 49 healthy children were used as healthy control group. Two groups of children's serum were collected on empty stomach and serum 25 hydroxyvitamin D_3[25- (OH) D_3] level was measured by ELISA method. According to the results of 25- (OH) D_3, the children of HSP were further divided into the normal group of vitamin D (20 ng/m L) (n=9), the deficiency group (15 ng/m L~20 ng/m L), the lack group (less than 15), and the severe deficiency group (less than 5). Results the serum level of 25- (OH) D_3 (16 + 6 ng/m L) in the HSP group was lower than that in the healthy control group (29 + 5 ng/m L) (P0.01). But there was no statistical significance (P0.05) before admission. Conclusion the serum 25- (OH) D_3 level of children with HSP was low, and the risk of kidney involvement and hormone use rate increased and the time of hospitalization was prolonged in children with low serum 25- (OH) D_3 level, but vitamin D supplementation had no therapeutic effect on HSP. Research.
【作者單位】： 貴州省人民醫(yī)院兒科;
【基金】：[基金項(xiàng)目]貴陽(yáng)市科技計(jì)劃項(xiàng)目筑科合同[20141001]51號(hào)
【分類(lèi)號(hào)】：R725.5

【參考文獻(xiàn)】

相關(guān)期刊論文 前6條

1 程雷;吳海燕;田慧琴;;維生素D在變應(yīng)性鼻炎發(fā)病中的作用[J];臨床耳鼻咽喉頭頸外科雜志;2016年09期

2 唐雪梅;;過(guò)敏性紫癜病因及免疫發(fā)病機(jī)制[J];實(shí)用兒科臨床雜志;2012年21期

3 徐祝菲;劉恩梅;鄧昱;;血清維生素D水平與兒童支氣管哮喘的相關(guān)性及其可能機(jī)制[J];實(shí)用兒科臨床雜志;2012年09期

4 盛曉陽(yáng);向偉;王衛(wèi)平;高舉;;兒童微量營(yíng)養(yǎng)素缺乏防治建議[J];中華兒科雜志;2010年07期

5 吳秀萍;;小兒36例復(fù)發(fā)及慢性過(guò)敏性紫癜臨床分析[J];中國(guó)全科醫(yī)學(xué);2010年09期

6 丁云峰;李志輝;吳天慧;段翠蓉;尋勱;張翼;銀燕;;兒童過(guò)敏性紫癜伴胰腺損害的臨床特征[J];中華實(shí)用兒科臨床雜志;2013年07期

【共引文獻(xiàn)】

相關(guān)期刊論文 前10條

1 范麗;劉衡;王予川;陳麗;周菁菁;崔玉霞;;血清維生素D水平與過(guò)敏性紫癜患兒病情及治療的關(guān)系[J];中國(guó)當(dāng)代兒科雜志;2017年07期

2 程雷;錢(qián)俊俊;田慧琴;;變應(yīng)性鼻炎研究的若干進(jìn)展[J];山東大學(xué)耳鼻喉眼學(xué)報(bào);2017年03期

3 陳曉康;陳澤坤;陳z齜，

本文編號(hào)：2017904