本文選題：氣陰兩虛 + 頻復發(fā)�。� 參考：《南京中醫(yī)藥大學》2012年碩士論文

【摘要】：目的：1.研究氣陰兩虛型頻復發(fā)腎病綜合征(FRNS)患兒與正常兒童之間血漿免疫球蛋白水平差異,遴選出具有顯著性差異的免疫球蛋白種類；2.分析氣陰兩虛型患兒血漿免疫球蛋白水平,分別與24小時蛋白尿定量、血清白蛋白和血漿膽固醇進行相關性分析,發(fā)現(xiàn)可能的特殊免疫狀態(tài)；3.討論中醫(yī)藥辨證治療氣陰兩虛型頻復發(fā)腎病綜合征的原則與方法,為中醫(yī)藥改善氣陰兩虛型FRNS特殊免疫狀態(tài)尋求可能的理論依據(jù)。 方法：1.選擇門診健康兒童作為正常組,將門診或住院確診的氣陰兩虛型FRNS患兒視為患病組；2.測定J正常組血漿免疫球蛋白(IgG、 IgE、 IgM、 IgA)水平作為對照；測定患病組兒童首次發(fā)病時、發(fā)病后1-2月和發(fā)病后4-7月時血漿免疫球蛋白、24小時尿蛋白定量、血漿白蛋白和血漿膽固醇等進行研究；3.比較正常組與患病組兒童血漿免疫球蛋白差異,遴選差異性顯著的免疫球蛋白類型；4.將具有顯著差異性的患病組免疫指標分別與24小時蛋白尿定量、血漿白蛋白等進行相關性分析。 結果：1.正常兒童與氣陰兩虛型FRNS患兒首次確診時一般資料比較,正常組19例,患病組33例,兩組間性別和年齡差異無統(tǒng)計學意義；2.血漿IgG患病組與正常組比較具有良好的顯著性差異,降低程度明顯；患病后4-7月時血漿IgG較患病1-2月時差異性有統(tǒng)計學意義,有所升高；3.血漿IgA患病組與正常組比較具有良好的顯著性差異,降低程度明顯；患病組內比較差異性無統(tǒng)計學意義；4.血漿IgM、 IgE正常組與患病組間以及患病組內部比較均無統(tǒng)計學意義；5.患病后1-2月和4-7月時,血漿IgG與血清白蛋白具有良好的正向直線相關性,與24小時蛋白尿定量和血漿膽固醇具有良好的負向直線相關性,而首次發(fā)病時相關性分析不能認為具有直線關系；6.血漿IgA除首次發(fā)病時與血漿白蛋白具有一定的正向直線相關性外,其余組內相關性分析均不能認為具有直線關系。 結論：1.氣陰兩虛型FRNS患兒男/女為2.3/1,發(fā)病年齡無顯著性差異；2.氣陰兩虛型FRNS患兒存在免疫球蛋白紊亂現(xiàn)象,血漿IgG和IgA較正常兒童下降明顯,IgM和IgE與正常兒童無顯著性差異；3.血漿IgG與患病后1-2月和4-7月時,與血清白蛋白具有良好的正向直線相關性,與24小時蛋白尿定量和血漿膽固醇具有良好的負向直線相關性；4.中醫(yī)藥可能會改善氣陰兩虛型FRNS患兒免疫球蛋白紊亂狀態(tài)。
[Abstract]:Purpose 1. To study the difference of plasma immunoglobulin levels between children with frequent recurrent nephrotic syndrome (FRNSs) of deficiency of qi and yin and normal children, and to select the type of immunoglobulin with significant difference. The level of plasma immunoglobulin in children with deficiency of qi and yin was analyzed, and the relationship between plasma immunoglobulin and 24 hour proteinuria, serum albumin and plasma cholesterol was analyzed respectively. This paper discusses the principles and methods of treating recurrent nephrotic syndrome of deficiency of qi and yin by differentiation of syndrome and syndrome of TCM, and seeks possible theoretical basis for improving the special immune state of FRNS with deficiency of both qi and yin in TCM. Methods: 1. The healthy children in outpatient clinic were selected as normal group, and the FRNS with deficiency of qi and yin in outpatient or inpatient was regarded as the disease group. The levels of IgG, IgE, IgM, IgA in plasma of J normal group were measured as control group, and the urine protein of 24 hours after the first onset, 1-2 months after onset and 4 to 7 months after onset of the disease in children in the diseased group were measured. Plasma albumin and cholesterol were studied. To compare the difference of plasma immunoglobulin between the normal group and the sick group, and to select the immunoglobulin type with significant difference. The correlation between immunological indexes and 24 hours proteinuria, plasma albumin and so on were analyzed. The results were as follows: 1. There were 19 cases in normal group and 33 cases in disease group. There was no significant difference in sex and age between the two groups. Compared with the normal group, the plasma IgG had a significant difference and a significant decrease, and the difference of plasma IgG between April and July was statistically significant compared with that of the normal group, and it was higher than that of the normal group (P < 0.05). Plasma IgA in the disease group compared with the normal group has a good significant difference, the degree of reduction is obvious, the difference between the disease group has no statistical significance. 4. There was no significant difference in plasma IgM, IgE between the normal group and the diseased group and within the diseased group. There was a good positive linear correlation between plasma IgG and serum albumin, a good negative linear correlation between plasma IgG and 24 hour proteinuria and plasma cholesterol at January-February and April-July after the onset of the disease. However, correlation analysis at the first time of onset could not be regarded as a linear relationship. Except for the positive linear correlation between plasma IgA and plasma albumin at the first time of onset, the correlation analysis in other groups could not be regarded as a linear relationship. The ratio of male to female in FRNS with deficiency of qi and yin was 2.3 / 1, and there was no significant difference in age of onset of FRNS. There was a disturbance of immunoglobulin in children with deficiency of qi and yin, and there was no significant difference in plasma IgG, IgA and IgE between children with FRNS and normal children. There was a good positive linear correlation between plasma IgG and serum albumin in January-February and April-July, and a good negative linear correlation with 24-hour proteinuria and plasma cholesterol. Chinese medicine may improve the immune globulin disorder in children with deficiency of qi and yin.
【學位授予單位】：南京中醫(yī)藥大學
【學位級別】：碩士
【學位授予年份】：2012
【分類號】：R726.91

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