本文選題：血小板減少性紫癜 + 兒童��； 參考：《廣東醫(yī)學》2017年22期

【摘要】：目的探討益生菌對免疫性血小板減少性紫癜(ITP)患兒細胞免疫功能的影響及其臨床意義。方法采用前瞻性隨機雙盲安慰劑對照臨床研究方法,將在我院兒科住院的60例ITP患兒分為治療組及安慰劑組,兩組均在常規(guī)治療基礎上加服益生菌或安慰劑治療,治療前及治療8周后均采血檢測T淋巴細胞亞群及細胞因子γ干擾素(IFN-γ)及白細胞介素-4(IL-4)濃度,并以30例健康同齡兒為對照組。結(jié)果與對照組比較,治療前病例組CD3、CD4、CD4/CD8及IL-4水平顯著降低,IFN-γ水平顯著增高[(61.67±11.34)%vs(71.00±7.38)%,(35.80±12.81)%vs(45.20±6.59)%,1.83±1.04 vs 2.27±0.67,(11.81±8.21)pg/m L vs(19.01±8.44)pg/m L,(5.94±3.80)pg/m L vs(2.08±0.95)pg/m L]。治療后8周,隨著病情好轉(zhuǎn),治療組CD4、CD4/CD8及IL-4水平均顯著高于安慰劑組,IFN-γ水平顯著低于安慰劑組[41.77±11.86)%vs(35.31±11.12)%,2.26±1.56 vs 1.53±0.80,(18.23±10.15)pg/m L vs(12.30±9.35)pg/m L,(2.36±1.81)pg/m L vs(4.03±3.48)pg/m L]。結(jié)論益生菌可調(diào)節(jié)機體細胞免疫功能,其可能通過恢復機體細胞免疫的平衡而對疾病的恢復起積極的促進作用。
[Abstract]:Objective to investigate the effect of probiotics on the cellular immune function of children with immune thrombocytopenic purpura (ITP) and its clinical significance. Methods a prospective, randomized, double-blind, placebo controlled clinical study was used to divide 60 children with ITP into the treatment group and the placebo group. All the two groups were Prebiotic on the basis of routine treatment. T lymphocyte subsets and cytokine gamma interferon (IFN- gamma) and interleukin -4 (IL-4) concentration were detected before and after 8 weeks of treatment, and 30 healthy children were compared with the control group. The results were significantly lower than those in the control group, CD3, CD4, CD4/CD8 and IL-4, and the level of IFN- gamma was significantly increased [(61] .67 + 11.34), (71 + 7.38)%, (35.80 + 12.81)%vs (45.20 + 6.59)%, 1.83 + 1.04 vs 2.27 + 0.67, pg/m L vs (11.81 + 8.21) pg/m L, pg/m L vs (pg/m L VS) were significantly higher than placebo group after the improvement of the condition, the level of the therapeutic group was significantly lower than that of the placebo group. [41.77 + 11.86)%vs (35.31 + 11.12)%, 2.26 + 1.56 vs 1.53 + 0.80, (18.23 + 10.15) pg/m L vs (12.30 + 9.35) pg/m L, (2.36 + 1.81) pg/m L vs (2.36 + 1.81) pg/m conclusions can regulate the cellular immune function of the body, which may play a positive role in the recovery of the disease by restoring the balance of cellular immunity.
【作者單位】： 廣西壯族自治區(qū)婦幼保健院兒科;廣西壯族自治區(qū)婦幼保健院檢驗科;
【基金】：中國疾病預防控制中心婦幼保健中心合生元母嬰營養(yǎng)與健康研究項目(編號:2013FY015)
【分類號】：R725.5

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