本文選題：咳嗽變異性哮喘 + 兒童��； 參考：《山西醫(yī)科大學》2017年碩士論文

【摘要】：目的:觀察肅肺調(diào)脾飲治療兒童咳嗽變異性哮喘(肺脾不調(diào)型)的臨床療效、遠期療效及復發(fā)率。方法:將符合兒童咳嗽變異性哮喘的西醫(yī)診斷標準和肺脾不調(diào)型的中醫(yī)證候標準,并且符合納入標準和排除標準的60例咳嗽變異性哮喘(肺脾不調(diào)型)患兒,隨機分為治療組和對照組,兩組均為30例,兩組均給予健康教育。治療組給予肅肺調(diào)脾飲,每次150ml,飯后溫服,一日2次;對照組給予普米克都保(有效成分主要為布地奈德粉吸入劑),1次200ug,一日2次。兩組的療程均為8周。在臨床研究過程中,兩組均不服用與肅肺調(diào)脾飲作用相同或相近的中草藥、中成藥等。治療前及治療后,兩組均行肺功能檢查(肺通氣功能、支氣管激發(fā)試驗),并記錄咳嗽癥狀評分、中醫(yī)證候評分及安全性觀察指標(一般體檢項目、血尿便常規(guī)、肝腎功能及臨床不良反應、不良事件等);經(jīng)統(tǒng)計學分析,評價肅肺調(diào)脾飲的療效。治療結(jié)束后,兩組均剔除咳嗽療效為無效的病例,隨訪3個月后行支氣管激發(fā)試驗并記錄咳嗽癥狀評分及復發(fā)率。結(jié)果:療效性評價:(1)對治療組治療前后咳嗽癥狀療效和咳嗽癥狀積分進行比較,差異具有統(tǒng)計學意義。(2)中醫(yī)證候療效比較:治療組總有效率為90.00%,對照組為73.33%,兩組差異有統(tǒng)計學意義。(3)咳嗽癥狀療效比較:治療組總有效率為86.67%,對照組為90.00%,兩組差異無統(tǒng)計學意義。(4)隨訪3個月后咳嗽療效:治療組總有效率為76.67%,對照組為50.00%,兩組差異有統(tǒng)計學意義。(5)兩組復發(fā)率:治療組復發(fā)率為11.54%,對照組為37.04%,兩組差異有統(tǒng)計學意義。(6)兩組治療前后肺功能指標比較(組內(nèi)比較),差異均具有統(tǒng)計學意義;治療后兩組肺功能指標PEF、PD20FEV1.0水平差異無統(tǒng)計學意義,而FEV1.0及FVC水平差異具有統(tǒng)計學意義。安全性評價:治療過程中,兩組患兒的一般體檢、血尿便常規(guī)、肝腎功能等檢查項目未見異常,也未出現(xiàn)臨床不良反應。結(jié)論:(1)肅肺調(diào)脾飲對兒童咳嗽變異性哮喘(肺脾不調(diào)型)治療有效,且未發(fā)現(xiàn)臨床不良反應;(2)肅肺調(diào)脾飲在改善咳嗽變異性哮喘(肺脾不調(diào)型)患兒中醫(yī)證候、提高遠期療效及降低復發(fā)率上優(yōu)于普米克都保;(3)肅肺調(diào)脾飲在改善咳嗽變異性哮喘(肺脾不調(diào)型)患兒的咳嗽癥狀上與普米克都保相當;(4)肅肺調(diào)脾飲可有效改善兒童咳嗽變異性哮喘(肺脾不調(diào)型)的肺功能,在降低氣道高反應性和改善PEF水平上與普米克都保相當;但在改善FEV1.0及FVC的水平上,肅肺調(diào)脾飲劣與普米克都保。
[Abstract]:Objective: to observe the clinical effect, long-term effect and recurrence rate of Sufei Tiaopi decoction in treating cough variant asthma in children. Methods: 60 children with cough variant asthma (lung and spleen irregularity) were divided into two groups: the western medicine diagnostic criteria and the TCM syndromes of lung and spleen disorder, and 60 children with cough variant asthma (lung and spleen irregular) who were included in the criteria and excluded. Two groups were randomly divided into treatment group and control group, both groups were 30 cases, both groups were given health education. The treatment group was given Sufei Tiaopi decoction, 150 ml per time, 2 times a day after meals, and the control group was treated with budesonide powder inhaler (budesonide powder inhaler, 200ug1, 2 times a day). The course of treatment was 8 weeks in both groups. In the course of clinical study, the two groups did not take the same or similar effects of Sufei Tiaopi Yin, Chinese herbal medicine, Chinese patent medicine and so on. Before and after treatment, both groups underwent pulmonary function examination (pulmonary ventilation function, bronchial provocation test, cough symptom score, TCM syndromes score and safety observation index (general physical examination items, hematuria routine, etc.) Liver and kidney function, clinical adverse reactions, adverse events, etc. The curative effect of Sufei Tiaopi Yin was evaluated by statistical analysis. At the end of the treatment, the two groups were treated with bronchial provocation test and the cough symptom score and recurrence rate were recorded after 3 months follow-up. Results: the curative effect and the score of cough symptom were compared before and after treatment in the treatment group. Comparison of the curative effect of TCM Syndrome: the total effective rate in the treatment group was 90.00,73.33 in the control group, and the difference between the two groups was statistically significant. 3) comparison of cough symptom efficacy: the total effective rate of the treatment group was 86.67 and that of the control group was 90.00B. the difference between the two groups was poor. After 3 months follow-up, the total effective rate of cough was 76.67 in the treatment group and 50.00in the control group. The difference between the two groups was statistically significant. The recurrence rate was 11.54 in the treatment group and 37.04 in the control group. The difference between the two groups was statistically significant. There were significant differences in pulmonary function between the two groups before and after treatment. After treatment, there was no significant difference in pulmonary function between the two groups, but there was a significant difference in FEV1.0 and FVC levels between the two groups. Safety evaluation: in the course of treatment, the general physical examination, hematuria routine, liver and kidney function of the two groups were not abnormal, and there were no clinical adverse reactions. Conclusion Sufei Tiaopi Yin is effective in the treatment of children's cough variant asthma (lung and spleen irregular type), and no clinical adverse reaction is found in the treatment of children with cough variant asthma (lung and spleen irregular type). It can improve TCM syndromes of cough variant asthma (lung and spleen irregular type). To improve the long-term effect and reduce the recurrence rate is better than that of Pumike du Bao Pao (3) Sufei Tiaopi Yin can effectively improve the cough symptoms of children with cough variant asthma (lung and spleen non-regulation type) compared with Pumike du Bao Pao 4) Sufei Tiaopi Yin can effectively improve the cough symptoms of children with cough variant asthma (lung and spleen non-regulation type) Sufei Tiaopi Yin can be effectively improved. Lung function of cough variant Asthma in Children In reducing airway hyperresponsiveness and improving the level of PEF, Pulmicort is comparable to Pumike, but in improving the level of FEV1.0 and FVC, Sufei regulating spleen drink is inferior to Pumike.
【學位授予單位】：山西醫(yī)科大學
【學位級別】：碩士
【學位授予年份】：2017
【分類號】：R272

【參考文獻】

相關(guān)期刊論文 前10條

1 吳艷玲;張海鄰;;兒童咳嗽變異性哮喘診治進展[J];中華兒科雜志;2016年04期

2 劉美;劉艷;王昶;;百部生物堿的藥理研究概況[J];黑龍江中醫(yī)藥;2015年04期

3 宋辰斐;夏以琳;;祛風通絡方治療兒童咳嗽變異性哮喘[J];吉林中醫(yī)藥;2014年06期

4 劉秋海;徐浩岑;邢燕如;陸玉廷;毛三寶;;咳嗽變異性哮喘在兒童慢性咳嗽中發(fā)病率的調(diào)查研究[J];中國醫(yī)刊;2014年06期

5 王小兵;;口服孟魯司特鈉咀嚼片致幼兒行為異常1例[J];中國醫(yī)院藥學雜志;2014年10期

6 利仕偉;;杏仁的加工炮制及現(xiàn)代藥理研究[J];內(nèi)蒙古中醫(yī)藥;2014年01期

7 徐玉萍;劉芳;孫靈芝;;孫靈芝教授治療兒童咳嗽變異性哮喘經(jīng)驗[J];中國中西醫(yī)結(jié)合兒科學;2013年05期

8 董左成;王秀玲;;“冬病夏治”穴位貼敷及拔罐治療咳嗽變異性哮喘臨床觀察[J];新中醫(yī);2013年01期

9 葉濤;詹珊珊;;吸入糖皮質(zhì)激素治療支氣管哮喘的不良反應[J];醫(yī)學綜述;2012年10期

10 洪建國;成煥吉;謝娟娟;楊儉治;陳強;何少茹;李云;周小琴;李昌崇;;布地奈德霧化吸入治療兒童咳嗽變異性哮喘研究[J];中國實用兒科雜志;2012年04期

相關(guān)碩士學位論文 前3條

1 張麗;基于數(shù)據(jù)挖掘技術(shù)對安效先教授診治兒童咳嗽變異性哮喘的臨床經(jīng)驗研究[D];中國中醫(yī)科學院;2014年

2 李建偉;布地奈德吸入治療對兒童咳嗽變異性哮喘的肺功能和炎性介質(zhì)的影響[D];天津醫(yī)科大學;2014年

3 周西;滌痰止咳湯治療兒童咳嗽變異性哮喘（頑痰伏肺證）的臨床療效觀察[D];成都中醫(yī)藥大學;2014年

，

本文編號：1924358