本文選題：硫酸鎂 + 霧化��； 參考：《重慶醫(yī)科大學(xué)》2012年碩士論文

【摘要】：目的 觀察硫酸鎂霧化是否能改善乙酰膽堿激發(fā)后的哮喘患兒肺功能，并與單用沙丁胺醇霧化及二者聯(lián)合霧化進(jìn)行比較。 方法 收集2011年11月-2012年3月到重慶醫(yī)科大學(xué)附屬兒童醫(yī)院復(fù)診的哮喘患兒84例，隨機(jī)分為三組，，均進(jìn)行肺功能激發(fā)，然后用不同藥物行支氣管舒張?jiān)囼?yàn)：（1）硫酸鎂組：霧化吸入等滲硫酸鎂溶液（7.5%，含硫酸鎂150mg）2ml；（2）沙丁胺醇組：霧化吸入沙丁胺醇溶液(含沙丁胺醇2.5mg)2ml；（3）硫酸鎂+沙丁胺醇組：霧化吸入硫酸鎂+沙丁胺醇混合溶液(含硫酸鎂150mg+沙丁胺醇2.5mg）2.5ml。觀察各組藥物霧化吸入后10分鐘、20分鐘肺功能（FEV1、PEF）改變情況。 結(jié)果 1.各組霧化吸入不同舒張藥物后肺功能均有顯著上升，比較各組舒張后的肺功能值無(wú)顯著統(tǒng)計(jì)學(xué)差異（P0.05），但沙丁胺醇組分別與硫酸鎂組、硫酸鎂+沙丁胺醇組舒張?jiān)囼?yàn)后10分鐘FEV1及PEF上升的百分比有顯著統(tǒng)計(jì)學(xué)差異（P0.05）； 2.各組內(nèi)不同時(shí)間段比較，硫酸鎂組與沙丁胺醇組舒張?jiān)囼?yàn)后的肺功能較激發(fā)后的肺功能有顯著統(tǒng)計(jì)學(xué)差異（P0.05），但硫酸鎂+沙丁胺醇組無(wú)顯著統(tǒng)計(jì)學(xué)差異（P0.05）。 結(jié)論 單用硫酸鎂霧化吸入有支氣管擴(kuò)張作用，霧化吸入后10分鐘內(nèi)對(duì)FEV1和PEF的改善效果不如單用沙丁胺醇好，但總體兩者無(wú)明顯差別。硫酸鎂+沙丁胺醇聯(lián)合霧化吸入雖有支氣管擴(kuò)張效應(yīng)，但本試驗(yàn)不能明確說(shuō)明二者聯(lián)合是否具有協(xié)同效應(yīng)。
[Abstract]:Purpose To observe whether magnesium sulfate atomization can improve lung function of asthmatic children after acetylcholine stimulation and compare it with salbutamol alone and combined atomization. Method From November 2011 to March 2012, 84 children with asthma were randomly divided into three groups. Then bronchodiastolic test was performed with different drugs: magnesium sulfate group: aerosol inhalation of magnesium sulfate solution 7.5, containing magnesium sulfate 150 mg / g 2ml / L) salbutamol group: atomized inhalation of salbutamol solution (containing 2.5 mg / g salbutamol) magnesium salbutamol sulfate group Aerosol inhalation of magnesium salbutamol sulfate mixed solution (containing magnesium sulfate 150mg salbutamol 2.5 mg / L 2.5 ml. The changes of FEV 1 and PEF were observed 10 minutes and 20 minutes after inhalation. Result 1. The pulmonary function of each group was significantly increased after inhaling different vasodilators, and there was no significant difference in pulmonary function between the groups after inhalation. However, salbutamol group and magnesium sulfate group, respectively, had no significant difference in the value of pulmonary function after aerosol inhalation, but salbutamol group and magnesium sulfate group respectively. The percentage of increase of FEV1 and PEF in magnesium salbutamol sulfate group was significantly higher than that in control group 10 minutes after diastolic test (P 0.05). 2. There was significant difference in pulmonary function between magnesium sulfate group and salbutamol group after diastolic test (P 0.05), but there was no significant difference between magnesium sulfate group and salbutamol group (P 0.05). Conclusion Magnesium sulfate atomized inhalation alone had bronchiectasis effect, and the improvement of FEV1 and PEF within 10 minutes after inhalation was not as good as salbutamol alone, but there was no significant difference between the two groups. Although the combined inhalation of magnesium salbutamol sulfate has bronchiectasis effect, it is not clear whether the combination of the two has synergistic effect.
【學(xué)位授予單位】：重慶醫(yī)科大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2012
【分類(lèi)號(hào)】：R725.6

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相關(guān)期刊論文 前2條

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本文編號(hào)：1918117