血清炎性因子、血小板相關(guān)指標(biāo)單獨(dú)及聯(lián)合檢測(cè)對(duì)新生兒細(xì)菌感染性敗血癥的診斷價(jià)值
本文選題:敗血癥 + 細(xì)菌。 參考:《山東醫(yī)藥》2017年02期
【摘要】:目的探討血清炎性因子、血小板相關(guān)指標(biāo)單獨(dú)及聯(lián)合檢測(cè)對(duì)新生兒細(xì)菌感染性敗血癥的診斷價(jià)值。方法選取細(xì)菌感染性敗血癥新生兒60例(敗血癥組)、非感染性疾病新生兒30例(對(duì)照組),檢測(cè)血清白細(xì)胞介素6(IL-6)、IL-8、降鈣素原(PCT)、C反應(yīng)蛋白(CRP)及血小板計(jì)數(shù)(PLT)、血小板體積(MPV)。結(jié)果敗血癥組IL-6、IL-8、PCT、CRP、MPV高于對(duì)照組(P均0.05),PLT低于對(duì)照組(P0.05);IL-6、IL-8、PCT、CRP、PLT、MPV單一指標(biāo)診斷新生兒細(xì)菌感染性敗血癥的靈敏度分別為83.33%、73.33%、88.33%、96.67%、78.33%、96.67%,特異度分別為73.33%、63.33%、83.33%、53.33%、63.33%、76.67%,IL-6+IL-8+PCT+CRP、PLT+MPV、IL-6+IL-8+PCT+CRP+PLT+MPV聯(lián)合檢測(cè)診斷靈敏度分別為58.33%、68.33%、35.00%,特異度分別為80.00%、73.33%、96.67%。結(jié)論多種血清炎性因子聯(lián)合血小板相關(guān)指標(biāo)檢測(cè)能明顯提高新生兒細(xì)菌感染性敗血癥診斷特異度,但敏感度不及單一指標(biāo)檢測(cè)。
[Abstract]:Objective to investigate the diagnostic value of serum inflammatory factors and platelet related indexes in neonatal bacterial septicemia. Methods 60 neonates with bacterial septicemia (septicemia group) and 30 neonates with non-infectious diseases (control group) were selected. The serum levels of IL-8, procalcitonin (PCT) -reactive protein (CRP), platelet count (PLT) and platelet volume (MPV) were measured. Results in septicemia group, the sensitivity of IL-6, IL-8, IL-8, PCT, CRP, MPV, MPV was higher than that in control group (P = 0.05, P < 0.05). The sensitivity of the single index of IL-6, PCT, CRP, PLT, MPV in diagnosing neonatal bacterial septicemia was 83.338.3388.3396.336.67, and the specificity was 73.3363.333.3353.3353.3353.3353.3353.3353.3353.3353.3353.3353.3353.33, respectively. The degree of 58.33 and 68.33 were 35.00, and the specificity was 80.000 and 73.33, respectively. Conclusion the detection of various serum inflammatory factors combined with platelet related indexes can improve the diagnostic specificity of neonatal bacterial septicemia, but the sensitivity is less than that of single index.
【作者單位】: 重慶醫(yī)科大學(xué)附屬兒童醫(yī)院;
【基金】:國(guó)家臨床重點(diǎn)專科建設(shè)項(xiàng)目(國(guó)衛(wèi)辦醫(yī)2013-544號(hào))
【分類號(hào)】:R722.131
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