本文選題：兒童失神癲癇 + 診斷標準��； 參考：《南京大學》2012年碩士論文

【摘要】：第一部分兒童失神癲癇2種診斷標準的臨床研究 目的兒童失神癲癇(Childhood absence epilepsy, CAE)是兒童期起病癲癇最常見類型之一,目前臨床工作對該病的診斷中存在2種診斷標準,即國際抗癲癇聯(lián)盟于1989年及2005年分別提出的“兒童失神癲癇診斷標準”。本文根據(jù)我院就診癲癇患者臨床資料探討國際抗癲癇聯(lián)盟兒童失神癲癇兩種診斷標準的臨床意義。 方法本研究對我院就診癲癇患者分別依據(jù)兩種診斷標準確診為兒童失神癲癇的兩組患者進行臨床特征及腦電圖特征的比較。 結果發(fā)作時程2005年標準診斷的患者較長,腦電圖誘發(fā)試驗陽性率1989年標準診斷的患者較高,發(fā)作多藥(三藥)控制率1989年標準診斷的患者中比例較高。 結論國際抗癲癇聯(lián)盟2005年診斷標準更能保證診斷患者的同質(zhì)性,發(fā)作易于控制。 第二部分兒童失神癲癇血氧依賴性功能磁共振研究 目的探討兒童失神癲癇發(fā)作期各腦區(qū)代謝變化。 方法應用EEG-fMRI掃描發(fā)作期與發(fā)作間期BOLD信號,并應用廣義線性模型發(fā)現(xiàn)腦區(qū)激活與抑制改變。 結果共有16例患者于EEG-fMRI掃描期間出現(xiàn)電-臨床發(fā)作36次,3Hz棘慢波放電期間fMRI信號增高出現(xiàn)于丘腦、額葉皮層、初級視覺區(qū)、聽覺區(qū)、運動皮層；fMRI降低出現(xiàn)于頂葉、扣帶回及基底節(jié)區(qū)。 結論丘腦與額葉皮層是參與失神癲癇病理生理機制的重要結構。
[Abstract]:Part I Clinical study of two diagnostic criteria for children with aphasia Objective Childhood absence epilepsy (CAEE) is one of the most common types of epilepsy in childhood, and there are two diagnostic criteria in clinical work. In 1989 and 2005, the International Anti-Epilepsy Federation put forward the Diagnostic criteria of Childhood Aphasia Epilepsy. Based on the clinical data of epileptic patients in our hospital, the clinical significance of two diagnostic criteria for children with aphasia in the International Anti-Epilepsy League (IAEU) was discussed. Methods the clinical and EEG features of two groups of epilepsy patients diagnosed as children with aphasia according to two diagnostic criteria were compared. Results the duration of seizure in 2005 was longer, the positive rate of EEG evoked test in 1989 was higher, and the control rate of multiple drugs (three drugs) was higher in 1989. Conclusion the international anti-epileptic union diagnostic standard in 2005 can ensure the homogeneity of the patients and the seizure is easy to control. The second part of functional magnetic resonance study on blood oxygen-dependent epilepsy in children with aphasia Objective to investigate the metabolic changes of brain regions in children with aphasia. Methods EEG-fMRI was used to scan the BOLD signal during the seizure and interictal period, and the generalized linear model was used to detect the changes of activation and inhibition in the brain region. Results A total of 16 patients showed increased fMRI signal in thalamus, frontal cortex, primary visual area, auditory area, motor cortex and parietal lobe during electrical-clinical seizure 36 times and 3 Hz spike and slow wave discharges during EEG-fMRI scan. Cingulate gyrus and basal ganglia. Conclusion thalamus and frontal cortex are important structures involved in pathophysiological mechanism of aphasia.
【學位授予單位】：南京大學
【學位級別】：碩士
【學位授予年份】：2012
【分類號】：R742.1

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