本文選題：鉛中毒 + 螯合　； 參考：《臨床兒科雜志》2017年09期

【摘要】：目的研究依地酸鈣鈉(Ca Na2EDTA)治療慢性中度鉛中毒療效,以優(yōu)化兒童鉛中毒的螯合治療方案。方法回顧分析2014年9月—2016年12月接受Ca Na2EDTA連續(xù)3個(gè)療程驅(qū)鉛治療的14例慢性中度鉛中毒患兒的臨床資料,分析住院期間每日24小時(shí)尿鉛水平,以及治療前、治療3天和5天后血鉛水平的變化。結(jié)果 14例患兒中,男4例、女10例,平均年齡(2.35±1.47)歲。Ca Na2EDTA治療后血鉛均顯著下降。三療程治療3天的血鉛下降值分別為治療5天下降值的0.76、0.77、0.72。三療程3天單位用藥血鉛下降值高于5天單位用藥血鉛下降值,差異均有統(tǒng)計(jì)學(xué)意義(P0.05)。三療程治療3天的尿鉛下降值分別為治療5天下降值的0.65、0.71、0.70。三療程3天單位用藥尿鉛排出量高于5天單位用藥尿鉛排出量,差異均有統(tǒng)計(jì)學(xué)意義(P0.05)。結(jié)論 Ca Na2EDTA驅(qū)鉛療效明顯,3天驅(qū)鉛效率高于5天,治療3天為一療程的方案或許可作為原5天一療程的替補(bǔ)方案。
[Abstract]:Objective to study the therapeutic effect of calcium iodide sodium calcium Na _ 2EDTA on chronic and moderate lead poisoning and to optimize the chelation regimen of lead poisoning in children. Methods the clinical data of 14 children with chronic moderate lead poisoning who were treated with Ca Na2EDTA for 3 consecutive courses from September 2014 to December 2016 were retrospectively analyzed. The urinary lead levels 24 hours a day during hospitalization and before treatment were analyzed. Changes of blood lead levels after 3 days and 5 days of treatment. Results among the 14 children, 4 were male and 10 were female. The mean age was 2.35 鹵1.47) years old. The blood lead decreased significantly after treatment with Ca Na2EDTA. The levels of blood lead in three courses of treatment for 3 days were 0.76 / 0.77 / 0.72 of those for 5 days of treatment, respectively. The decreasing value of blood lead per unit drug for 3 days was higher than that for 5 days, and the difference was statistically significant (P 0.05). After 3 days of treatment, the levels of urinary lead drop were 0.65U 0.71U 0.70 of that of 5-day treatment, respectively. The excretion of lead per unit drug in 3 days of three courses of treatment was higher than that in 5 days of treatment, and the difference was statistically significant (P 0.05). Conclusion the efficacy of Ca Na2EDTA in removing lead in 3 days is higher than that in 5 days. The treatment of 3 days as a course of treatment may be used as a replacement for the original 5 days of treatment.
【作者單位】： 上海交通大學(xué)醫(yī)學(xué)院附屬新華醫(yī)院教育部和上海市環(huán)境與兒童健康重點(diǎn)實(shí)驗(yàn)室;
【基金】：科技部九七三課題(No.2012CB525001)
【分類號】：R725.9
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本文編號：1816632