本文選題：腎瘢痕 + 危險因素��； 參考：《臨床兒科雜志》2017年09期

【摘要】：腎瘢痕可導致高血壓、蛋白尿、慢性腎臟病、甚至終末期腎病的可能。研究兒童腎瘢痕形成的危險因素,有利于早發(fā)現(xiàn)、早診斷、早預防、早治療。高級別的膀胱輸尿管反流,反復的泌尿道感染,以及延誤治療都是腎瘢痕形成的危險因素。但是仍有一些因素,如性別和年齡,先天性因素與腎瘢痕的關(guān)系目前仍存在爭議。近年研究發(fā)現(xiàn),尿液無創(chuàng)指標,如尿中性粒細胞明膠酶相關(guān)脂質(zhì)運載蛋白、尿內(nèi)皮素-1及風險預測模型均可預測腎瘢痕的形成,而預防應用抗生素雖可減少泌尿道感染的發(fā)生,但并不能降低腎瘢痕形成的風險。文章綜述了兒童腎瘢痕形成的可能危險因素和預測指標,為臨床對腎瘢痕的早期發(fā)現(xiàn)、及時干預和有效預防提供依據(jù),以期減少腎瘢痕的形成和進展。
[Abstract]:Scarring can lead to hypertension, proteinuria, chronic kidney disease, and even end-stage kidney disease. To study the risk factors of renal scar formation in children is beneficial to early detection, early diagnosis, early prevention and early treatment. High-grade bladder-ureter reflux, recurrent urinary tract infections, and delayed treatment are risk factors for renal scarring. However, there are still some factors, such as sex and age, congenital factors and renal scar is still controversial. Recent studies have found that urinary noninvasive indicators, such as urinary neutrophil gelatinase-associated lipid carrier protein, urinary endothelin-1 and risk prediction models, can predict the formation of renal scar, and that the prophylactic use of antibiotics can reduce the incidence of urinary tract infection. But it does not reduce the risk of scarring in the kidneys. The possible risk factors and predictors of renal scar formation in children were reviewed in order to provide evidence for early detection, timely intervention and effective prevention of renal scar in order to reduce the formation and progress of renal scar.
【作者單位】： 復旦大學附屬兒科醫(yī)院腎臟科上海市腎臟發(fā)育和兒童腎臟病研究中心;
【分類號】：R726.9

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1 黃錫年,黃建萍,楊霽云;小兒腎瘢痕形成的有關(guān)問題[J];中華兒科雜志;2000年05期

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本文編號：1794108