本文選題：卡波西樣血管內(nèi)皮瘤 + 卡梅現(xiàn)象　； 參考：《鄭州大學(xué)》2017年碩士論文

【摘要】：目的探討卡波西樣血管內(nèi)皮瘤(KHE)伴卡梅現(xiàn)象(KMP)患兒糖皮質(zhì)激素受體(GRa、GRβ)的表達與激素敏感性的關(guān)系。方法收集自2013年5月年-2016年5月來我院治療的卡波西樣血管內(nèi)皮瘤伴卡梅現(xiàn)象的患兒25例,男性9例,女性16例,平均年齡為(2.4±1.5)月。所有通過入選標準的患兒均進行為期1周的激素治療,根據(jù)療效評判標準,分為敏感組和抵抗組。待患兒的血小板得到提升,凝血功能得到改善,對于手術(shù)和麻醉的耐受力得到提高,并完善其他的術(shù)前準備,行手術(shù)治療,以外科手術(shù)切除的15例多余的健康組織作為對照組,對其手術(shù)切除組織進行免疫組化SP法檢測,比較分析敏感組、抵抗組、對照組糖皮質(zhì)激素受體(GRa、GRβ)陽性表達的數(shù)量、強度和分布特點。結(jié)果1.GRa的表達強度在三組中的無統(tǒng)計學(xué)意義。GRa陽性細胞數(shù)量在敏感組中高于抵抗組(P0.05)。2.GRβ的表達強度在抵抗組中顯著高于敏感組、對照組(P0.01);GRβ陽性細胞數(shù)量在敏感組、對照組、抵抗組中呈逐漸上升趨勢,且有明顯顯著性意義(P0.01)。3.GRa/GRβ表達強度的比值在抵抗組中顯著低于敏感組、對照組(P0.01);GRa/GRβ陽性細胞數(shù)量的比值在敏感組、對照組、抵抗組中呈逐漸下降趨勢,且有明顯顯著性意義(P0.01)。結(jié)論1.KHE伴KMP患兒瘤體組織中GRa、GRβ的表達與GC敏感性密切相關(guān)。2.GC的敏感性可能與GRa有一定的關(guān)系,但相對GRβ來說不起主導(dǎo)作用。3.GRβ表達增高可能是GC抵抗的重要原因,并對GC敏感性的影響起主要作用。4.GRβ表達的增高可能對GRa起負性調(diào)節(jié)作用,GRa、GRβ表達比例的平衡失調(diào),可能是GC抵抗的重要原因,還有待進一步研究證實。
[Abstract]:Objective to investigate the relationship between the expression of glucocorticoid receptor (GRAR 尾) and hormone sensitivity in children with carpoxiform hemangioendothelioma (KHEA) and KMPs. Methods from May 2013 to May 2016, 25 cases of Carbosiform hemangioendothelioma with Kamei phenomenon were collected, including 9 males and 16 females, with an average age of 2.4 鹵1.5 months. All the children who passed the inclusion criteria were treated with hormone for one week and were divided into sensitive group and resistance group according to the criteria of curative effect. When the platelets were improved, the coagulation function was improved, the tolerance to surgery and anesthesia was improved, and other preoperative preparations were improved, surgical treatment was performed, and 15 cases of superfluous healthy tissue surgically resected were used as the control group. Immunohistochemical SP method was used to detect the expression of glucocorticoid receptor GRaR 尾 in sensitive group, resistance group and control group. Results the expression intensity of 1.GRa in the three groups was significantly higher than that in the resistant group. The expression of GRa 尾 was significantly higher in the sensitive group than in the resistant group, and the number of positive cells in the control group was higher than that in the sensitive group and the control group, and the number of GRa 尾 positive cells in the control group was significantly higher than that in the resistant group, and the number of GRa 尾 positive cells in the control group was significantly higher than that in the control group. In the resistance group, the ratio of GRAR 尾 expression was significantly lower than that in the sensitive group, and the ratio of the number of GRAR 尾 positive cells in the control group was decreased gradually in the sensitive group, and in the control group and resistance group, there was a decrease in the number of GRAR 尾 positive cells in the control group and in the control group, while in the control group, the ratio of GRaR 尾 positive cells in the control group was decreased gradually. And there was significant difference in P0.01C. Conclusion the expression of gr 尾 in the tumor tissues of children with 1.KHE and KMP is closely related to the sensitivity of GC. 2. The sensitivity of GC may be related to the sensitivity of GC, but the increase of expression of gr 尾 may be an important reason for GC resistance, but it does not play a leading role in the expression of gr 尾. 4. The increased expression of gr 尾 may play a negative role in regulating the balance of gr 尾 expression in GRa and may be an important reason for GC resistance.
【學(xué)位授予單位】：鄭州大學(xué)
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2017
【分類號】：R732.2

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