本文選題：濕熱型 + 泄瀉�。� 參考：《廣州中醫(yī)藥大學(xué)》2015年碩士論文

【摘要】：目的：輪狀病毒腸炎屬小兒泄瀉的范疇,“泄瀉”按其不同的臨床表現(xiàn)可分為“風(fēng)寒證”、“濕熱證”、“脾虛證”“傷食證”,而嶺南地區(qū),濕氣困重,濕邪蘊而化熱,故輪狀病毒腸炎雖多集中爆發(fā)在秋冬兩季,但受地理因素影響,多表現(xiàn)為“濕熱證”。故從收集病例的可行性及代表性而言,以濕熱型輪狀病毒腸炎作為研究對象效果更優(yōu)。導(dǎo)師所在課題組總結(jié)多年臨床經(jīng)驗,認為小兒泄瀉病機關(guān)鍵為脾虛濕盛,結(jié)合嶺南地區(qū)特點,濕熱型輪狀病毒腸炎當(dāng)以“運脾化濕,清熱止瀉”為治法,蒼苓散具有運脾化濕之功效,加予黃芩、鳳尾草、火炭母、雞蛋花清熱止瀉,課題采用蒼苓散加味用來治療嬰幼兒濕熱證輪狀病毒腸炎,并根據(jù)患兒的臨床療效觀察及使用相關(guān)治療方案前、后檢測血清中干擾素γ(IFN-γ)變化,論證蒼苓散加味是否通過調(diào)節(jié)IFN-γ而發(fā)揮作用,從免疫學(xué)角度探討蒼苓散加味治療輪狀病毒腸炎的作用機制。方法：1.將符合診斷標(biāo)準(zhǔn)的37例患兒按照治療方法分別入組,組別為對照組及觀察組,對照組13例,實驗組24例。對照組予思密達治療,觀察組予蒼苓散加味治療,兩組患兒根據(jù)病情變化給予相應(yīng)的對癥處理,療程為3天。2.通過對37例患兒進行療效對比,并檢測相應(yīng)治療前、后血清IFN-γ含量的變化。3.癥候積分結(jié)果：1.對照組及觀察組治療后血清IFN-γ含量均增加,相比對照組而言,觀察組在治療后血清IFN-γ含量明顯增加(P0.05),差異有統(tǒng)計學(xué)意義。2.觀察組治療療效為92%,明顯好于對照組的545(P0.05)差異有統(tǒng)計學(xué)意義,且無不良反應(yīng)。3.臨床證候總積分：觀察組治療后的總積分要低于對照組治療后的總積分,兩者的差異具有統(tǒng)計學(xué)意義(P0.05)。結(jié)論：蒼苓散加味對嬰幼兒輪狀病毒腸炎療效顯著,能明顯改善輪狀病毒腸炎癥狀,如大便次數(shù)的減少及大便性狀改善等,且安全無副作用。蒼苓散加味治療本病可能是通過提高患兒IFN-γ含量而發(fā)揮療效。
[Abstract]:Objective: rotavirus enteritis belongs to the category of infantile diarrhea. According to its different clinical manifestations, diarrhea can be divided into "wind-cold syndrome", "damp-heat syndrome", "spleen deficiency syndrome" and "injured food syndrome". Therefore, rotavirus enteritis mostly occurred in autumn and winter, but affected by geographical factors, it was characterized by dampness and heat syndrome. Therefore, from the point of view of the feasibility and representativeness of collecting cases, it is better to take the moist heat rotavirus enteritis as the research object. The teacher's research group summarized the clinical experience for many years, and considered that the key to the pathogenesis of diarrhea in children was spleen deficiency and dampness, and combined with the characteristics of Lingnan region, the damp-heat type rotavirus enteritis should be treated with "transferring spleen to dehumidification, clearing heat and stopping diarrhea" as the treatment method. Cangling Powder has the effect of transferring spleen and transforming dampness. It is added to Scutellaria baicalensis, Phellodendron chinensis, Fo Tan, Egg Hua to clear heat and stop diarrhea. The subject is to use Cangling Powder to treat rotavirus enteritis in infants with damp-heat syndrome. According to the clinical curative effect of the children and the changes of IFN- 緯 in serum before and after the use of the related treatment regimen, it was demonstrated whether Cangling Powder could play a role in regulating IFN- 緯. To explore the mechanism of treatment of rotavirus enteritis by Cangling Powder from immunological angle. Method 1: 1. 37 children who met the diagnostic criteria were divided into two groups: control group and observation group (n = 13), control group (n = 13) and experimental group (n = 24). The control group was treated with smecta, the observation group was treated with Cangling powder, and the two groups were given corresponding symptomatic treatment according to the changes of the disease. The course of treatment was 3 days. 2. The changes of serum IFN- 緯 levels before and after treatment were compared in 37 children. Symptom score: 1. Compared with the control group, the level of serum IFN- 緯 in the observation group increased significantly after treatment, the difference was statistically significant. The curative effect of the observation group was 92.It was significantly better than that of the control group (P 0.05), and there was no adverse reaction. The total integral of clinical syndrome: the total integral after treatment in the observation group was lower than that in the control group, and the difference between the two groups was statistically significant (P 0.05). Conclusion: Cangling Powder has significant curative effect on infantile rotavirus enteritis and can obviously improve the symptoms of rotavirus enteritis, such as the decrease of defecation times and the improvement of defecation character, and it is safe and has no side effect. Cangling Powder treatment of this disease may be by increasing the content of IFN- 緯 and play a therapeutic effect.
【學(xué)位授予單位】：廣州中醫(yī)藥大學(xué)
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2015
【分類號】：R272

【參考文獻】

相關(guān)期刊論文 前10條

1 王海曼;張淑文;;厚樸酚藥理作用的研究進展[J];北京中醫(yī)藥;2009年07期

2 高有桂;金玉;柳頤齡;葉新華;;輪狀病毒腸炎患兒血清及糞便白細胞介素-18和干擾素-γ含量的變化及意義[J];中國當(dāng)代兒科雜志;2006年04期

3 張明發(fā);沈雅琴;;甘草及其活性成分抗炎與抗炎機制的研究進展[J];現(xiàn)代藥物與臨床;2011年04期

4 徐春娥;陳薇;;干擾素系統(tǒng)與病毒的相互作用[J];中國生物工程雜志;2006年04期

5 方鶴松;;小兒腹瀉病的診斷和治療[J];實用兒科臨床雜志;2011年19期

6 馬珍;王忠誠;王世芬;過巧珊;劉乃娥;;菌群失調(diào)引起真菌性小兒腹瀉的菌種分布特點及微生態(tài)調(diào)節(jié)劑的應(yīng)用[J];實用醫(yī)學(xué)雜志;2006年03期

7 胡小英;陳曉剛;許華;羅菲;高爍爍;黃蓓;;七味白術(shù)散治療小兒輪狀病毒腸炎腸道微生態(tài)的研究[J];陜西中醫(yī);2012年07期

8 陳治珍;許華;許雙虹;劉華;吉訓(xùn)超;董秀蘭;;虛實辨證推拿治療小兒急性非細菌感染性腹瀉的臨床對照研究[J];廣州中醫(yī)藥大學(xué)學(xué)報;2013年01期

9 付梅紅;朱東海;方婧;宋紅月;楊濱;熊玉蘭;;蒼術(shù)的化學(xué)、分子生藥學(xué)和藥理學(xué)研究進展[J];中國中藥雜志;2009年20期

10 李倩楠;葛曉群;;黃芩苷的解熱作用及對細胞因子的影響[J];中國中藥雜志;2010年08期

，

本文編號：1782443