新生兒基因過(guò)氧化物酶體增殖激活受體PPARγC161T多態(tài)性與低出生體質(zhì)量的關(guān)系
本文選題：新生兒 + 低出生體質(zhì)量?jī)?/strong>�。� 參考：《桂林醫(yī)學(xué)院》2012年碩士論文
【摘要】：目的：探討新生兒基因過(guò)氧化物酶增殖激活受體PPARγC161T多態(tài)性對(duì)低出生體質(zhì)量(早產(chǎn)兒、足月小于胎齡兒)的影響。方法：用橫斷面調(diào)查法,使用統(tǒng)一的調(diào)查表,對(duì)入住桂林醫(yī)學(xué)院附屬醫(yī)院分娩的孕婦及其單胎、活胎、低出生體質(zhì)量和健康對(duì)照新生兒進(jìn)行調(diào)查,共得到有效樣本268個(gè)母親-新生兒對(duì),并根據(jù)出生體質(zhì)量和孕周進(jìn)行性分組,分為健康對(duì)照組和低出生體質(zhì)量組,其中包括早產(chǎn)兒組和足月小于胎齡兒組。使用多聚酶鏈-限制性片段長(zhǎng)度多態(tài)性(PCR-RFLP)方法檢測(cè)其外周血基因PPARγC161T單核苷酸多態(tài)性,分析不同基因型對(duì)低出生體質(zhì)量的影響。結(jié)果：1.根據(jù)雙變量Logistic回歸分析得出低出生體質(zhì)量與父母的受教育水平、職業(yè),家庭居住環(huán)境和氛圍及維生素的補(bǔ)充相關(guān),相關(guān)系數(shù)分別為-0.691、-0.434、-0.343、-0.337、-0.269、0.296、0.235。2. PPARγC161T多態(tài)性CC型、CT型與TT型分布及基因頻率分布在健康對(duì)照組和低出生體質(zhì)量組的足月小于胎齡兒和早產(chǎn)兒組分別為53.33%,14.44%,21.11%、75.00%,18.18%,6.82%和76.67%、20.00%、3.33%,早產(chǎn)兒組和足月小于胎齡兒組無(wú)明顯差異。攜帶C等位基因增加低出生體質(zhì)量的風(fēng)險(xiǎn),低出生體質(zhì)量組足月兒、早產(chǎn)兒攜帶CC基因型風(fēng)險(xiǎn),與正常出生體質(zhì)量?jī)旱腛R值分別為1.938(95%CT:1.001-3.75, P=0.002)、2.122(95%CI:1.091-4.127, P=0.000)。結(jié)論：低出生體質(zhì)量是環(huán)境和遺傳因素共同作用的結(jié)果,PPARγC161T多態(tài)性與低出生體質(zhì)量有關(guān),C等位基因可能是低出生體質(zhì)量的遺傳易感基因。
[Abstract]:Objective: to investigate the effect of PPAR 緯 C161T polymorphism on low birth weight (premature infants, full-term infants with small gestational age). Methods: a cross-sectional survey and a unified questionnaire were used to investigate the pregnant women and their single, live, low birth weight and health control newborns in the affiliated hospital of Guilin Medical College. A total of 268 effective mother-newborn pairs were obtained and divided into healthy control group and low birth weight group according to birth weight and gestational age. Polymerase chain restriction fragment length polymorphism (PCR-RFLP) was used to detect PPAR 緯 C161T single nucleotide polymorphisms in peripheral blood, and the effects of different genotypes on low birth weight were analyzed. The result is 1: 1. The distribution and gene frequency of PPAR 緯 C161T polymorphism CC type CT and TT genotype in healthy control group and low birth weight group were 53.33 and 14.44%, respectively, and 75.00% and 76.6777.0020.003.33%, respectively. There was no significant difference between premature infants and full-term infants with less than gestational age. Carrying C allele increased the risk of low birth weight. The odds ratio of CC genotype in low birth weight group and premature infant was 1.938 鹵95% CT1: 1.001-3.75, P 0.002 + 2.122% 95% CI1.091-4.127, P0.0000.000 respectively. Conclusion: low birth weight is the result of environmental and genetic factors. PPAR 緯 C161T polymorphism is associated with low birth weight.
【學(xué)位授予單位】：桂林醫(yī)學(xué)院
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2012
【分類號(hào)】：R722.1
【參考文獻(xiàn)】
相關(guān)期刊論文 前10條
1 張珍梅;賈志新;蘇秀蘭;;PPAR-γ基因與原發(fā)性高血壓的研究進(jìn)展[J];內(nèi)蒙古醫(yī)學(xué)院學(xué)報(bào);2010年04期
2 賈俊亞;丁國(guó)華;;腎臟中腎素-血管緊張素系統(tǒng)的生理和病理生理作用[J];生理科學(xué)進(jìn)展;2008年01期
3 李莎;靜進(jìn);陳子立;譚文爭(zhēng);麥鳳愛(ài);戴蓮桃;;早期干預(yù)對(duì)提高低出生體質(zhì)量?jī)荷窠?jīng)心理及生長(zhǎng)發(fā)育的影響[J];實(shí)用兒科臨床雜志;2008年11期
4 王丹華;;關(guān)注早產(chǎn)兒的營(yíng)養(yǎng)與健康[J];實(shí)用兒科臨床雜志;2009年14期
5 李小晶;麥堅(jiān)凝;肖華;楊思淵;徐開(kāi)壽;;早產(chǎn)兒氣質(zhì)特征與運(yùn)動(dòng)發(fā)育的相關(guān)性[J];實(shí)用兒科臨床雜志;2010年14期
6 曾賓;樊娟;劉穎;趙方;周于新;張雙船;;新生兒病房院內(nèi)血流感染的高危因素[J];實(shí)用兒科臨床雜志;2010年14期
7 郭雯;陸順;;低出生體重兒影響因素研究[J];實(shí)用預(yù)防醫(yī)學(xué);2010年09期
8 張陽(yáng);茍文麗;;PPARγ和MMP-9在妊娠期高血壓疾病患者胎盤組織的表達(dá)及其臨床意義[J];西安交通大學(xué)學(xué)報(bào)(醫(yī)學(xué)版);2010年03期
9 任祥芳;;農(nóng)村早產(chǎn)婦孕期20項(xiàng)危險(xiǎn)因素暴露情況流行病學(xué)研究[J];中國(guó)婦幼保健;2010年34期
10 閆振成,祝之明,沈成義,趙志剛,倪銀星,鐘健,聶海;代謝綜合征PPARγ C-161T基因多態(tài)性與頸動(dòng)脈損害的相關(guān)研究[J];中華醫(yī)學(xué)雜志;2004年07期
，本文編號(hào)：1774585
本文鏈接：http://sikaile.net/yixuelunwen/eklw/1774585.html
