本文選題：咳嗽變異性哮喘　切入點(diǎn)：IgE　出處：《湖南中醫(yī)藥大學(xué)》2012年碩士論文

【摘要】：目的：觀察咳嗽變異性哮喘(CVA)患兒經(jīng)過分期治療后血清免疫球蛋白E(IgE)和嗜酸性粒細(xì)胞陽離子蛋白(ECP)水平的變化,探討IgE和ECP檢測的臨床意義,闡明中藥治療CVA的作用機(jī)理。 方法：選取符合本研究標(biāo)準(zhǔn)的CVA(虛寒證)患兒60例(觀察組),根據(jù)隨機(jī)數(shù)字表法分為治療組和對照組,每組30例。治療組(中藥組)發(fā)作期給予溫肺化痰飲,緩解期給予補(bǔ)肺健脾飲；對照組(西藥組)服用孟魯司特鈉,發(fā)作期加服氨茶堿治療。另收取20例到我院體檢的健康兒童做健康對照。觀察組治療前后均抽血測血清IgE及ECP,比較治療前后這兩種因子的變化情況,并分析和中藥治療的關(guān)系。 結(jié)果：治療前兩組患兒的IgE和ECP水平與健康組比較差異有顯著統(tǒng)計學(xué)意義(P0.01),治療組和對照組比較二者差異無統(tǒng)計學(xué)意義(P0.05),具有可比性。治療后治療組IgE和ECP水平較治療前差異有顯著統(tǒng)計學(xué)意義(P0.01),對照組I gE水平較治療前差異無統(tǒng)計學(xué)意義(P0.05),而ECP水平較治療前差異有顯著統(tǒng)計學(xué)意義(P0.01)。治療后治療組和健康組比較IgE無明顯統(tǒng)計學(xué)意義(P0.05),而ECP差異有顯著的統(tǒng)計學(xué)意義(P0.01)；治療后對照組和健康組比較二者均有顯著的統(tǒng)計學(xué)差異(P0.01)。受試對象治療過程中,均無對藥物過敏及病情惡化等不良反應(yīng)。 結(jié)論：IgE和ECP可能與CVA的發(fā)病有關(guān),并且這兩種因子對于指導(dǎo)CVA的診斷和治療有一定的參考價值；中藥能改善CVA患兒體內(nèi)異常增高的IgE水平,作用優(yōu)于對照組。
[Abstract]:Objective: to observe the changes of serum immunoglobulin (IgE) and eosinophil cationic protein (eep) levels in children with cough variant asthma (CVA) after treatment by stages, to explore the clinical significance of IgE and ECP detection and to elucidate the mechanism of traditional Chinese medicine in the treatment of CVA. Methods: 60 children with CVA (deficiency and cold syndrome) were randomly divided into treatment group and control group according to the method of random digital table. In the remission period, Bufei Jianpi decoction was given, while the control group (western medicine group) took montelukast sodium, Aminophylline was taken in the attack period, and 20 healthy children who came to our hospital for health control. Serum IgE and ECPwere measured before and after treatment in the observation group. The changes of these two factors were compared before and after treatment, and the relationship between the two factors and traditional Chinese medicine treatment was analyzed. Results: the levels of IgE and ECP in the two groups before treatment were significantly different from those in the healthy group (P 0.01), but there was no significant difference between the treatment group and the control group (P 0.05). The level of Ige in the control group was not significantly different from that before treatment, but the level of ECP was significantly higher than that before treatment. There was no significant difference in IgE between the treatment group and the healthy group after treatment. There was significant difference in ECP between control group and healthy group after treatment (P 0.01), and there was significant difference between control group and healthy group (P 0.01) during the course of treatment, and there was no significant difference between control group and healthy group in the course of treatment, and there was no significant difference between control group and healthy group in the course of treatment. There were no adverse reactions such as allergy to drugs and deterioration of the disease. ConclusionIgE and ECP may be related to the pathogenesis of CVA, and these two factors have certain reference value in guiding the diagnosis and treatment of CVA. Chinese herbal medicine can improve the abnormal increase of IgE level in children with CVA, and the effect is better than that in the control group.
【學(xué)位授予單位】：湖南中醫(yī)藥大學(xué)
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2012
【分類號】：R272

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