本文選題：先天性心臟病　切入點：葉酸服用　出處：《西安交通大學(xué)學(xué)報(醫(yī)學(xué)版)》2017年03期 　論文類型：期刊論文

【摘要】：目的探討圍孕期婦女服用葉酸與產(chǎn)兒先天性心臟病的關(guān)系,為采取有針對性的干預(yù)措施提供科學(xué)依據(jù)。方法應(yīng)用分層隨機整群抽樣方法,抽取陜西省30個區(qū)縣。對2010年1月至2013年11月間曾經(jīng)懷孕、符合納入標(biāo)準(zhǔn)、已知生育結(jié)局并知情同意的育齡婦女及其生育子女進(jìn)行入戶調(diào)查。采用Logistic回歸模型控制相關(guān)影響因素分析婦女葉酸服用與產(chǎn)兒先天性心臟病發(fā)生的風(fēng)險關(guān)系。結(jié)果本研究共納入28 354名育齡婦女,其活產(chǎn)兒先天性心臟病患病率為7.3‰,育齡婦女圍孕期葉酸服用率為64.4%,但其中按照規(guī)范服用葉酸的婦女僅占17.2%。圍孕期婦女規(guī)范服用葉酸可能是產(chǎn)兒先天性心臟病的保護(hù)因素,單因素分析結(jié)果顯示OR為0.502(95%CI:0.279~0.902);在控制了家庭背景因素,母親因素以及孕期接觸危險因素后多因素分析發(fā)現(xiàn),葉酸規(guī)范服用仍然是先天性心臟病的保護(hù)性因素(調(diào)整OR=0.512,P=0.046)。然而,尚未發(fā)現(xiàn)不規(guī)范服用葉酸對產(chǎn)兒先天性心臟病發(fā)生的保護(hù)作用。結(jié)論按照規(guī)范時間和劑量服用葉酸(孕前3個月至孕早期3個月,每天服用0.4mg,且累計服用時間超過90d),可能預(yù)防先天性心臟病的發(fā)生。
[Abstract]:Objective to explore the relationship between folic acid use and congenital heart disease in infants during pregnancy, and to provide scientific basis for taking targeted intervention measures. Methods stratified random cluster sampling was used. Select 30 districts and counties in Shaanxi Province. For those who were pregnant between January 2010 and November 2013, they met the inclusion criteria. A household survey was conducted among women of childbearing age and their childbearing children who had known the outcome of birth and informed consent. The risk of congenital heart disease in infants was analyzed by using Logistic regression model to control the related influencing factors and to analyze the relationship between folic acid use in women and the incidence of congenital heart disease in infants. A total of 28,354 women of childbearing age were included in this study. The prevalence rate of congenital heart disease in live infants was 7.3 鈥，

本文編號：1638673