本文選題：病毒性腦炎　切入點(diǎn)：腦脊液　出處：《中華醫(yī)院感染學(xué)雜志》2017年09期 　論文類型：期刊論文

【摘要】：目的探討病毒性腦炎(VE)患兒血清及腦脊液基質(zhì)金屬蛋白酶(MMPs)、基質(zhì)金屬蛋白酶組織抑制劑(TIMP)、降鈣素原(PCT)及腫瘤壞死因子-ɑ(TNF-α)指標(biāo)水平變化,以期為VE早期診斷提供數(shù)據(jù)依據(jù)。方法選取2013年1月-2016年1月醫(yī)院就診VE患兒124例為觀察組,另選取本研究組康復(fù)后小兒50例為對(duì)照組,觀察兩組血清及腦脊液MMP-2、MMP-9、TIMP-1、PCT、TNF-α水平變化,同時(shí)將觀察組按照病情嚴(yán)重程度、病情緩急程度劃分,觀察不同病情嚴(yán)重程度及緩急程度血清及腦脊液觀察指標(biāo)變化。結(jié)果觀察組不同標(biāo)本間觀察指標(biāo)對(duì)比,差異均有統(tǒng)計(jì)學(xué)意義(P0.05),觀察組同標(biāo)本同項(xiàng)指標(biāo)均高于對(duì)照組(P0.05),觀察組病情為輕度71例、重度53例,重度患兒同標(biāo)本同項(xiàng)指標(biāo)均高于輕度患兒(P0.05),觀察組急性82例,非急性42例,急性患兒同標(biāo)本同項(xiàng)指標(biāo)均高于非急性患兒(P0.05)。結(jié)論 MMPs、TIMP、PCT及TNF-α均參與VE發(fā)生及發(fā)展過(guò)程,監(jiān)測(cè)其血清及腦脊液PCT、TNF-α水平對(duì)中樞神經(jīng)系統(tǒng)感染具有定性作用,綜合監(jiān)測(cè)具有評(píng)估疾病發(fā)展情況,預(yù)測(cè)治療結(jié)局作用。
[Abstract]:Objective to investigate the changes of serum and cerebrospinal fluid matrix metalloproteinase (MMPsN), tissue inhibitor of matrix metalloproteinase (TIMP), procalcitonin (PCT) and tumor necrosis factor- (TNF- 偽) in children with viral encephalitis (VEV). Methods from January 2013 to January 2016, 124 children with VE were selected as observation group and 50 children in this study group as control group. The changes of serum and CSF levels of MMP-2MMP-9TIMP-1and PCTNF- 偽 were observed in both groups. At the same time, the observation group was divided into two groups according to the severity of the disease and the degree of priority of the disease, and the changes of serum and cerebrospinal fluid (CSF) were observed according to the severity of the disease and the degree of urgency. Results the observed indexes were compared among the different specimens of the observation group. The difference was statistically significant (P 0.05). The same items in the observation group were higher than those in the control group (P 0.05). In the observation group, 71 cases were mild, 53 cases were severe, and the same index of the same specimen in the severe group was higher than that in the mild group (P 0.05). In the observation group, there were 82 cases of acute and 42 cases of non-acute. Conclusion the levels of MMPsTIMPnPCT and TNF- 偽 are involved in the pathogenesis and development of VE, and the levels of serum and cerebrospinal fluid PCTNF-a may play a qualitative role in central nervous system infection. Comprehensive monitoring can evaluate the development of disease and predict the outcome of treatment.
【作者單位】： 鄭州人民醫(yī)院兒科;貴州醫(yī)科大學(xué)附屬醫(yī)院兒科;鄭州市兒童醫(yī)院東區(qū)醫(yī)院神經(jīng)內(nèi)科;鄭州人民醫(yī)院檢驗(yàn)科;
【基金】：河南省教育廳科學(xué)技術(shù)研究重點(diǎn)基金資助項(xiàng)目(142106310017)
【分類號(hào)】：R725.1

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