本文選題：過敏性紫癜　切入點(diǎn)：兒童　出處：《中國實(shí)用兒科雜志》2017年07期 　論文類型：期刊論文

【摘要】：目的測定過敏性紫癜(HSP)患兒糞便中細(xì)菌代謝相關(guān)產(chǎn)物短鏈脂肪酸水平并研究其意義。方法選取2014年6月至2015年1月昆明醫(yī)科大學(xué)第一附屬醫(yī)院兒科確診為HSP 27例患兒,其中男15例、女12例;平均年齡(9.0±2.8)歲。均符合中華醫(yī)學(xué)會兒科學(xué)分會免疫學(xué)組推薦的HSP診斷標(biāo)準(zhǔn)。健康兒童28例為對照組,其中男16例,女12例;平均年齡(9.5±1.3)歲。收集保存HSP患兒急性期、恢復(fù)期和對照組的糞便標(biāo)本。應(yīng)用氣相色譜技術(shù)定量測定對照組、HSP急性期組和恢復(fù)期組糞便中短鏈脂肪酸包括乙酸、丙酸、丁酸、異丁酸、異戊酸濃度。結(jié)果對照組、HSP急性期組和恢復(fù)期組糞便乙酸濃度(mol/g)分別為(6.04±2.15)×10~(-5)、(3.90±3.08)×10~(-5)和(4.73±3.95)×10~(-5),對照組與急性期組比較,對照組高于急性期組且差異有統(tǒng)計(jì)學(xué)意義(P0.05),而與恢復(fù)期組比較,差異無統(tǒng)計(jì)學(xué)意義(P0.05)。丁酸濃度分別為[4.53(2.68,5.47)]×10~(-5)、[1.48(0.14,3.78)]×10~(-5)和[0.93(0.31,1.75)]×10~(-5),對照組高于急性期組及恢復(fù)期,且均有統(tǒng)計(jì)學(xué)意義(P0.017)。丙酸濃度分別為[3.22(2.22,4.20)]×10~(-5)、[1.80(7.84,3.66)]×10~(-5)和[2.68(0.46,4.93)]×10~(-5),組間差異無統(tǒng)計(jì)學(xué)意義(P0.017)。異丁酸濃度分別為[0.19(0.07,0.30)]×10~(-5)、[0.17(0.08,0.59)]×10~(-5)和[0.14(0.03,0.30)]×10~(-5),異戊酸濃度分別為[0.13(0.04,0.19)]×10~(-5)、[0.13(0.06,0.32)]×10~(-5)和[0.09(0.02,0.23)]×10~(-5),組間差異無統(tǒng)計(jì)學(xué)意義(P0.017)。結(jié)論 HSP急性期患兒糞便乙酸、丁酸顯著降低�；謴�(fù)期糞便乙酸雖有升高,但仍未完全回到正常水平,而糞便中丁酸濃度更低。
[Abstract]:Objective to determine the allergic purpura (HSP) in children with fecal bacterial metabolic products of short chain fatty acid level and investigate its significance. Methods the pediatric diagnosis of the First Affiliated Hospital of Kunming Medical University from June 2014 to January 2015 27 HSP cases, including 15 cases of male, 12 female; the average age (9 + 2.8) years old. Are in line with Chinese medicine Subspecialty Group of immunology recommended diagnostic criteria of HSP. 28 healthy children as control group, 16 cases were male, 12 were female; the average age (9.5 + 1.3) years old. The collection and preservation of children with HSP in acute period, recovery period and stool specimens of the control group. The control group was determined quantitatively by gas chromatography, HSP acute group and recovery of short chain fatty acids in feces group including acetic acid, propionic acid, butyric acid and isobutyric acid, isovaleric acid concentration. Results in the control group, HSP group and acute phase group fecal acetate concentration recovery (mol/g) respectively (6.04 + 2.15) * 10~ (-5 (3.90). 鹵3.08)脳10~(-5)鍜，

本文編號：1570914