本文關(guān)鍵詞： 麻杏石甘湯 肺炎喘嗽 臨床研究　出處：《廣州中醫(yī)藥大學(xué)》2012年碩士論文　論文類型：學(xué)位論文

【摘要】：目的： 本研究通過對(duì)麻杏石甘湯內(nèi)各藥不同劑量配伍應(yīng)用,探討其中各中藥成分在肺炎喘嗽痰熱閉肺證中的臨床療效,為今后臨床應(yīng)用麻杏石甘湯在各藥物劑量上提供一定理論依據(jù)。 方法： 將符合標(biāo)準(zhǔn)的180例患兒按實(shí)際情況分為6組,每組按不同藥物劑量配比應(yīng)用麻杏石甘湯輔助西藥治療(原方配比：麻、杏、石、甘為3：2：6：2),即麻黃組(用麻、杏、石、甘比為6：2：6：2的方劑輔以西藥治療)、杏仁組(用麻、杏、石、甘比為3：4：6：2的方劑輔以西藥治療)、石膏組(用麻、杏、石、甘比為3：2：12：2的方劑輔以西藥治療)、甘草組(用麻、杏、石、甘比為3：2：6：4的方劑輔以西藥治療)、對(duì)照組(用麻、杏、石、甘比為3：2：6：2的方劑輔以西藥治療)與空白組(以純西醫(yī)西藥治療),記錄每例患兒發(fā)熱、咳嗽、咳痰、氣喘癥狀的消失時(shí)間(若有反復(fù),按最后消失時(shí)間計(jì)算),肺部Up音消失時(shí)間(干濕Up音均消失時(shí)間),治療前后(入院時(shí)及治療4天后)血清CRP濃度等數(shù)據(jù)為主要觀察指征。 成果： ①麻杏石甘湯配合西藥治療對(duì)肺炎各主要指征的觀察上,消失時(shí)間均短于單純西藥治療(P0.05)。改善實(shí)驗(yàn)室指標(biāo)CRP的作用與單純西藥治療相當(dāng)(P0.05)。②各組在發(fā)熱、咳嗽、咳痰、氣喘、Up音等指征改善方面效果分布不盡相同。各組CRP治療前后改善分布不具有統(tǒng)計(jì)學(xué)意義(P0.05)。 結(jié)論： 根據(jù)研究數(shù)據(jù)可知,麻杏石甘湯配合西藥治療對(duì)肺炎咳嗽、咳痰、氣喘、Up音各指征的改善上,效果明顯優(yōu)于單純西藥治療。其中麻黃平喘之效為全方之首,臨床上增大其用量可用于小兒肺炎見氣喘明顯,氣道高反應(yīng)性,中高熱并無汗,伴咳嗽咳痰的患兒。苦杏仁止咳作用最強(qiáng),增大其用量可用于小兒肺炎見有痰咳嗽,或干咳無痰,稍有氣喘或無氣喘,發(fā)熱不明顯的患兒。石膏退熱效果在各藥中最強(qiáng),增大其用量可用于小兒肺炎初期見高熱,汗多,煩渴,或發(fā)熱持續(xù)不退,咳嗽咳痰氣喘不甚的患兒。甘草化痰效果強(qiáng)于其余藥物,增大其用量可用于小兒肺炎見有痰咳嗽,無發(fā)熱或低熱,氣喘不甚的患兒,且藥味甘甜,易于小兒口服。肺炎因小兒體質(zhì)差異、病原體種類不同、侵襲部位不同,而出現(xiàn)不同的表現(xiàn)。不同配比的麻杏石甘湯可因應(yīng)不同癥狀,有所側(cè)重地減輕各癥狀對(duì)患兒造成的損傷,在臨床上值得推廣。
[Abstract]:Objective:. In this study, the clinical effect of different doses of each drug in Maxingshigan decoction on the syndrome of pneumonia, cough, phlegm and heat blocking lung was studied. To provide some theoretical basis for the clinical application of maxing Shigan decoction in various drug doses. Methods:. 180 children who met the standard were divided into 6 groups according to the actual situation. Each group was treated with maxing Shigan decoction with different dosage ratio. (the original formula: Ma, Xing, Shi, Gan is 3: 2: 6: 2, that is, ephedra group (with Ma, Xing, Shi, The prescription of 6: 2: 6: 2 was treated with western medicine, the almond group (with hemp, apricot, stone, Gambi of 3: 4: 6: 2) was treated with western medicine, the gypsum group (with flax, apricot, stone, gumbi = 32: 12: 2) with western medicine, the group with licorice (with hemp, apricot, stone, stone, etc.) with western medicine, and the group with licorice (with hemp, apricot, stone, stone, etc. The prescription of 3: 2: 6: 4 was treated with western medicine, the control group (with the prescription of 3: 2: 6: 2) and the blank group (treated with pure western medicine) and the control group (with the prescription of 3: 2: 6: 2) and the control group (treated with pure western medicine) recorded each child's fever, cough, expectoration, The time of disappearance of asthmatic symptoms (if repeated, calculated according to the last time of disappearance, the time of disappearance of lung up sound (both dry and wet up), and the serum CRP concentration before and after treatment (admission and 4 days after treatment) were the main indications. Outcome:. 1the observation of the main indications of pneumonia treated by Maxingshigan decoction and western medicine was shorter than that of western medicine alone. The effect of improving the laboratory index CRP was similar to that of western medicine alone in fever, cough and expectoration. The effect of improving the symptoms of asthma and up was different in different groups, but there was no significant difference between the two groups before and after CRP treatment (P 0.05). Conclusion:. According to the research data, the effect of Maxingshigan decoction combined with western medicine on the improvement of the symptoms of pneumonia, cough, expectoration and asthma is obviously better than that of western medicine alone. The effect of ephedra on relieving asthma is the first of all Fang Zhi. It can be used in children with pneumonia with obvious asthma, airway hyperresponsiveness, moderate hyperthermia and no sweat, and cough and expectoration. Almond has the strongest antitussive effect, increasing the dosage of almond can be used in children pneumonia to see sputum cough. Or dry cough without phlegm, a little asthma or no asthma, fever is not obvious. The best antipyretic effect of gypsum in every medicine, increase its dosage can be used in early childhood pneumonia to see high fever, sweating more, irritating thirst, or fever continues to be, The effect of liquorice on phlegm reduction is stronger than that of other drugs. Increasing its dosage can be used in children with pneumonia with sputum cough, no fever or low fever, and mild asthma, and the medicine is sweet and sweet. Pneumonia is easy for children to take orally. Pneumonia is caused by different types of pathogens, different invasion sites, and different manifestations. Different proportions of Maxingshigan decoction can respond to different symptoms. It is worth popularizing in clinical practice to alleviate the injury caused by various symptoms in children.
【學(xué)位授予單位】：廣州中醫(yī)藥大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2012
【分類號(hào)】：R272

【引證文獻(xiàn)】

相關(guān)博士學(xué)位論文 前1條

1 趙思佳;葛根芩連湯、麻杏石甘湯量效的循證醫(yī)學(xué)評(píng)價(jià)[D];北京中醫(yī)藥大學(xué);2013年

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本文編號(hào)：1538465