本文關(guān)鍵詞：地氟烷和七氟烷用于兒科麻醉術(shù)后恢復(fù)的Meta分析　出處：《廣西醫(yī)科大學(xué)》2013年碩士論文　論文類型：學(xué)位論文

  更多相關(guān)文章： 地氟烷/地氟醚 七氟烷/七氟醚 兒科麻醉 meta分析

【摘要】：目的評價(jià)地氟烷和七氟烷用于兒科麻醉術(shù)后恢復(fù)的效果及不良反應(yīng)。 方法電子檢索PubMed, Cochrane圖書館,EMbase,中國生物醫(yī)學(xué)文獻(xiàn)數(shù)據(jù)庫(CBM)和維普中文期刊數(shù)據(jù)庫(VIP),文獻(xiàn)檢索時(shí)間均從建庫至2012年2月,收集地氟烷和七氟烷用于兒科麻醉的隨機(jī)對照試驗(yàn)(RCTs)。按Cochrane Handbook5.0.1提供的隨機(jī)對照試驗(yàn)質(zhì)量的評價(jià)標(biāo)準(zhǔn)評價(jià)納入研究的方法學(xué)質(zhì)量,使用RevMan5.0對納入的患者資料進(jìn)行Meta分析。劑量資料采用加權(quán)均數(shù)差值(WMD)進(jìn)行分析,計(jì)算95%可信區(qū)間,計(jì)數(shù)資料采用比值比(0R)進(jìn)行分析,計(jì)算95%可信區(qū)間�？ǚ綑z驗(yàn)進(jìn)行異質(zhì)性檢驗(yàn),固定效應(yīng)模型采用Mantel-Haenszel法分析,隨機(jī)效應(yīng)模型采用Der SimonialLaird法分析,對于無法合并的資料進(jìn)行描述性分析。 結(jié)果納入9篇RCTs,包括840例患兒,其中地氟烷組414例,七氟烷組426例。Meta分析結(jié)果顯示：在早期蘇醒時(shí)間上地氟烷組快于七氟烷組,在術(shù)后恢復(fù)時(shí)間上兩組差異沒有統(tǒng)計(jì)學(xué)意義,在術(shù)后躁動的發(fā)生率上地氟烷組要高于七氟烷組,術(shù)后惡心嘔吐(PONV)和嚴(yán)重疼痛(score≥6)兩組差異沒有統(tǒng)計(jì)學(xué)意義,眼心反射(OCR)兩組差異亦沒有統(tǒng)計(jì)學(xué)意義。 結(jié)論本研究結(jié)果表明地氟烷組麻醉術(shù)后早期蘇醒快于七氟烷,蘇醒期躁動發(fā)生率高于七氟烷組麻醉。在術(shù)后恢復(fù)、術(shù)后不良反應(yīng)和眼心反射方面兩者之間沒有差異。
[Abstract]:Objective to evaluate the efficacy and adverse effects of desflurane and sevoflurane in the recovery of pediatric anesthesia. Methods PubMed, Cochrane Library, Chinese Biomedical Literature Database (CBM) and Weipu Chinese Journal Database (VIP) were searched electronically. The retrieval time of literature was from the construction of the database to February 2012. Collection of desflurane and sevoflurane for paediatric anesthesia in a randomized controlled trial (RCTs). To evaluate the quality of randomized controlled trials according to the evaluation criteria provided by Cochrane Handbook5.0.1. RevMan5.0 was used to analyze the patient data and the weighted mean value was used to analyze the dose data. The 95% confidence interval was calculated. Counting data were analyzed by ratio ratio of 0 R, 95% confidence interval was calculated. Chi-square test was used to test heterogeneity, and fixed effect model was analyzed by Mantel-Haenszel method. The stochastic effect model is analyzed by Der SimonialLaird method. Results 9 RCTs were included, including 840 children, including 414 in desflurane group. Meta-analysis of 426 cases in sevoflurane group showed that desflurane group was faster than sevoflurane group in early recovery time, and there was no significant difference in postoperative recovery time between the two groups. The incidence of postoperative restlessness was higher in the upper halothane group than in the sevoflurane group. There was no significant difference between the two groups in postoperative nausea and vomiting PONVV and severe pain score 鈮，

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