[Abstract] Objective : To investigate the dexmedetomidine anesthesia for the prevention of postoperative delirium in elderly patients the clinical effect . Methods: 2011.06-2012.06 to our hospital for elective abdominal surgery intravenous anesthesia with endotracheal intubation of 100 patients , all patients were elderly, aged 60 and above ; randomly divided into observation group and control group, n = 50 cases ; The patients given before induction of general anesthesia Right dexmedetomidine 0.8ug/kg, continuous infusion for 10 minutes, followed by intubation . maintenance dose after intubation by 0.4ug/kg/h, stopping 30 minutes before surgery , control patients intravenous normal saline , the same sequence intubation ; observed in patients with sleep score, delirium incidence and duration of hospitalization .Results: The statistical observation group were sleep score was (2.18 ± 0.7), two cases of delirium in patients , the rate was 4.00% ; patients with sleep score of the control group (3.71 ± 0.9), 9 patients with delirium , the rate was 18.00 % ; two groups of patients with sleep scores and compare the incidence of delirium were statistically significant (P <0.05). Conclusion: elderly surgical patients with severe , continuous intravenous infusion of dexmedetomidine will be able to improve sleep quality , prevention of postoperative delirium in elderly patients the incidence of anesthesia , effectively reduce the incidence of delirium in patients suitable for promoting the use of clinical surgery .
Key words Dexmedetomidine ; Epidural anesthesia ; Delirium

譫妄是一種以興奮性增高為主的高級神經(jīng)中樞急性活動失調(diào)狀態(tài)，臨床上主要表現(xiàn)為意識模糊、定向力喪失、感覺錯亂（幻覺、錯覺）、躁動不安、語言雜亂等[1]。譫妄可發(fā)生于急性感染的發(fā)熱期間，也可見于某些藥物中毒、代謝循環(huán)障礙以及中樞神經(jīng)系統(tǒng)疾病。在臨床外科，老年重癥患者的譫妄發(fā)生率比較高，有關研究顯示危重患者發(fā)生率在35％—80％。 右美托嘧啶是一種高選擇性的α2腎上腺素能受體激動藥，，具有鎮(zhèn)靜、抗焦慮、鎮(zhèn)痛等作用，適合用于ICU全身麻醉的手術患者氣管插管和機械通氣時的鎮(zhèn)靜。我院為探討該藥對預防老年患者全麻術后發(fā)生譫妄的臨床效果而開展了此次研究，現(xiàn)報道如下：

1資料與方法
2結果  
3討論
參考文獻



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