本文選題：犬細(xì)小病毒　切入點：血液生化　出處：《河南科技大學(xué)》2017年碩士論文　論文類型：學(xué)位論文

【摘要】：犬細(xì)小病毒病(Canine parvovirus,CPV)多發(fā)于幼犬和未接種疫苗的犬,死亡率一直都很高。CPV病例多表現(xiàn)嘔吐,腹瀉,便血等癥狀,在臨床中多為對癥治療,而對CPV發(fā)病時期器官功能學(xué)研究較少。本課題通過對CPV患犬在治療中血液生化指標(biāo)進行連續(xù)監(jiān)測,對其進行分析處理來研究CPV患犬的血液生化指標(biāo)的變化情況。并找出與CPV患犬密切相關(guān)的生化指標(biāo),弄清CPV患犬生化指標(biāo)的變化及意義,闡明其相關(guān)機制,為CPV臨床治療提供指導(dǎo),進而提高CPV的治愈率。CPV患犬的處理:對符合試驗條件的CPV患犬進行3次血液生化指標(biāo)檢測,分別是在患犬入院當(dāng)天,入院治療的第三天及第五天進行,檢測在當(dāng)天用藥治療開始前進行。數(shù)據(jù)的處理:指標(biāo)樣本測定的結(jié)果不在參考范圍內(nèi)時,計為變異1次,得出變異樣本總數(shù),將變異樣本總數(shù)除以指標(biāo)樣本總數(shù),即為該指標(biāo)變異樣本率;把生化各項指標(biāo)劃分為六項功能,對每項功能包含指標(biāo)的變異樣本做求和處理,即為變異樣本總數(shù),與該功能包含指標(biāo)的總樣本數(shù)相比,即為該功能變異百分率;CPV痊愈犬與死亡犬生化指標(biāo)的對比:試驗分痊愈、死亡、對照三組,分析三組實驗結(jié)果。CPV連續(xù)病例的監(jiān)測:選取在CPV病例中變化明顯的五項生化指標(biāo),淀粉酶、脂肪酶、肌酸激酶、堿性磷酸酶、白蛋白,在完成三次監(jiān)測的死亡病例和存活病例中,對比分析兩組結(jié)果。CPV病例生化指標(biāo)樣本變異率變化比較明顯的是:堿性磷酸酶、肌酸激酶、血清鈣、天門冬氨酸氨基轉(zhuǎn)移酶、總膽紅素、白蛋白、脂肪酶、血清磷,CPV對患犬生化指標(biāo)影響情況為:堿性磷酸酶濃度升高,肌酸激酶濃度升高,血清鈣濃度降低,天門冬氨酸氨基轉(zhuǎn)移酶濃度升高,總膽紅素濃度降低,白蛋白濃度降低,脂肪酶濃度升高,血清磷濃度升高;CPV病例顯著性變化的臟器(指標(biāo))有心臟功能、血清鈣、肝功能、白蛋白和胰腺功能;對痊愈組與死亡組進行對比結(jié)果顯示,有顯著性差異的是胰腺功能降低、血清鈣濃度下降及白蛋白缺乏,這可能是導(dǎo)致CPV患犬最終死亡的主要原因;在CPV指標(biāo)的連續(xù)檢測過程中,指標(biāo)的變化情況可能預(yù)示著疾病發(fā)展的方向。結(jié)果表明,CPV患犬在治療期間,應(yīng)及時監(jiān)測堿性磷酸酶、肌酸激酶、血清鈣、天門冬氨酸氨基轉(zhuǎn)移酶、總膽紅素、白蛋白、脂肪酶、血清磷等生化指標(biāo),特別是胰腺功能、血清鈣及蛋白質(zhì)指標(biāo)的變化,根據(jù)檢測結(jié)果,隨時調(diào)整臨床用藥,可能會提高CPV的治療率,降低死亡率。
[Abstract]:Canine parvovirus virus (CPV) is more common in puppies and unvaccinated dogs. The mortality rate of CPV cases is always very high. CPV cases often show vomiting, diarrhea, hematochezia and other symptoms. However, there were few studies on organ function during the onset of CPV. The aim of this study was to continuously monitor the blood biochemical indexes of CPV dogs during the course of treatment. To study the changes of blood biochemical indexes in dogs with CPV, to find out the biochemical indexes closely related to CPV dogs, to find out the changes and significance of biochemical indexes of CPV dogs, and to elucidate the related mechanism. To provide guidance for the clinical treatment of CPV, and then to improve the cure rate of CPV. The treatment of CPV. The blood biochemical indexes of CPV dogs that meet the test conditions were tested three times, respectively, on the day of admission, on the third and fifth day of admission, respectively. Data processing: when the results of the index sample determination are not within the reference range, they are counted as one variation, the total number of the variation samples is obtained, and the total number of the variation samples is divided by the total number of the index samples. That is to say, the sample rate of variation is the index, the biochemical indexes are divided into six functions, and the sum of the variation samples that each function contains, that is, the total number of variation samples, is compared with the total sample number of the index included by the function. That is to say, the percentage of functional variation and the comparison of biochemical indexes between CPV cured dogs and dead dogs were compared. The results of the three groups were analyzed as follows: the monitoring of continuous cases of CPV: selecting five biochemical indexes which changed obviously in CPV cases. Amylase, Lipase, Creatine Kinase, Alkaline Phosphatase, Albumin. In the death and survival cases that completed three times monitoring, the variation rate of biochemical indexes in the two groups were compared and analyzed: alkaline phosphatase (ALP). The effects of creatine kinase, serum calcium, aspartate aminotransferase, total bilirubin, albumin, lipase and serum phosphatase on biochemical indexes were as follows: the concentration of alkaline phosphatase increased, the concentration of creatine kinase increased, and the concentration of serum calcium decreased. Aspartate aminotransferase concentration increased, total bilirubin concentration decreased, albumin concentration decreased, lipase concentration increased, serum phosphorus concentration increased. The results of the comparison between the cured group and the dead group showed that the decrease of pancreatic function, the decrease of serum calcium concentration and the deficiency of albumin may be the main causes of the death of the dogs with CPV. During the continuous detection of CPV, the changes of the indexes may indicate the development direction of the disease. The results showed that alkaline phosphatase, creatine kinase, serum calcium, aspartate aminotransferase should be monitored in time during treatment. The changes of total bilirubin, albumin, lipase and serum phosphorus, especially the changes of pancreatic function, serum calcium and protein, may increase the treatment rate of CPV and reduce the mortality.
【學(xué)位授予單位】：河南科技大學(xué)
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2017
【分類號】：S858.292

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