臨床植入物的成功取決于植入物表面和骨組織細(xì)胞之間的相互作用,包括促進(jìn)骨整合作用、長(zhǎng)期穩(wěn)定性能及優(yōu)異的抗菌作用。羥基磷灰石（HA）是一種具有促進(jìn)骨生成作用的生物陶瓷材料,被廣泛應(yīng)用于骨科和牙科領(lǐng)域。其中,單相及雙摻雜磷灰石因其優(yōu)異的骨傳導(dǎo)能力受到大量關(guān)注,有望應(yīng)用于骨科及牙科植入物等領(lǐng)域。本文旨在研究Zn2+和Sr2+兩種重要的生物陽(yáng)離子共摻雜羥基磷灰石材料的生物學(xué)特性,采用水熱合成法,將前驅(qū)體中Zn2+和Sr2+替代部分Ca2+位置,制備了 6種不同摻雜濃度Zn2+和Sr2+的納米羥基磷灰石材料。同時(shí),通過(guò)XRD、ICP、FTIR、拉曼光譜、FESEM、TEM和TGA等技術(shù)手段對(duì)納米材料共摻雜、結(jié)晶度、相純度、晶格參數(shù)、元素組成、顆粒形貌及熱穩(wěn)定性等性能進(jìn)行評(píng)價(jià)。結(jié)果表明,樣品中Zn2+的含量隨著Sr2+的摻雜量增加而提高,然而,在20%Zn10%Sr或10%Zn20%Sr的溶液中,磷灰石晶體結(jié)構(gòu)消失。此外,體外細(xì)胞實(shí)驗(yàn)表明,即使在含高濃度Zn2+（10%）雙摻雜的樣品表面,MC3T3-E1細(xì)胞仍具有良好的增殖能力,表明Sr2+可以抵消Zn2+的細(xì)胞毒性作用,提高材料的生物相容性。此外... 

【文章頁(yè)數(shù)】：172 頁(yè)

【學(xué)位級(jí)別】：博士

【文章目錄】：
摘要
ABSTRACT
Chapter 1 Introduction
    1.1 Aims and Objective
Chapter 2 Literature Review
    2.1 Biomaterials
    2.2 Hip and Knee Replacement
    2.3 Calcium Phosphates
    2.4 HA Coating for Orthopaedics Implants
    2.5 Synthesised HA and Ions-substitution
    2.6 Substituted HA coating
    2.7 Bone: A Solid Structure and Living Tissue
    2.8 Fabrication of (Sr, Zn)-HA Coating
    2.9 Plasma Spray Process
    2.10 Characteristics of Hydroxyapatite Coating
Chapter 3 Materials and Methods
    3.1 Synthesis of Co-substituted Hydroxyapatite and Reagents
    3.2 Atmospheric Plasma Spraying method
    3.5 Sample Preparation
    3.6 Coating Parameters
    3.7 Characterization of HA Nano-powder and Plasma Coating
    3.8 Cell culture
    3.9 Statistical Analysis
Chapter 4 Synthesis, Characterization and in Vitro Evaluation of Zincand Strontium Binary Doped Hydroxyapatite for BiomedicalApplication
    4.1 Characterization of Zn-Sr Substituted HA
    4.2 Chemical Analysis
    4.3 FTIR
    4.4 SEM Observation
    4.5 TEM Morphology Observation
    4.6 Raman Spectroscopy
    4.7 Thermal Behavior
    4.8 In Vitro Cell-Material Interaction
    4.9 Discussion
Chapter 5 Prepration and Materials Cells in Teraction of Sr Containingand Zn Substituted Hydroxyapatite Plasma Sprayed Coating onTI-6AL-4V Alloy
    5.1 Surface Morphology
    5.2 Phase Composition
    5.3 Bonding strength
    5.4 Morphological Characteristic of the Coating
    5.5 In Vitro Phase Analysis
    5.6 Dissolution study
    5.7 In Vitro Cell-Material Interaction
    5.8 Discussion
Chapter 6 Mechanical, BiologicalI and Antibacterial Characteristics ofPlasma-Sprayed (Sr, Zn) Substituted Hydroxyapatite Coating
    6.1 Characterizations of (Sr, Zn)-HA Powders
    6.2 Surface Roughness and Morphologies of Coating
    6.3 Cross-sectional Microstructures
    6.4 Phase Evolution of Coating
    6.5. Raman Spectroscopy
    6.6 Mechanical properties
    6.7 Contact Angle
    6.8 In-Vitro Cell-Material Interaction
    6.9 Discussion
Chapter 7 Conclusion
References
Acknowledgement
Author's Biography
Published academic paper during school



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